The Anatomy of the SARS-CoV-2 Biomedical Literature: Introducing the CovidX Network Algorithm for Drug Repurposing RecommendationOriginal Paper Published on 2020-08-202022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, [키워드] Algorithm analyzed Antiviral antiviral drug applied approach benefit biomedical calculated candidate Chloroquine clinical trial clinical trials compounds coronavirus disease COVID-19 COVID-19 pandemic COVID-19 treatment disease drug drug candidate Drug repurposing Evidence Favipiravir Health Hydroxychloroquine identify informatics instance investigated knowledge losartan mechanism Methylprednisolone network network algorithm objective off-label outcome pandemic potential treatments Protein ranking Rapamycin Remdesivir repurposing Result Ritonavir the SARS-CoV-2 Treatment [DOI] 10.2196/21169 PMC 바로가기 [Article Type] Original Paper
Animal models of mechanisms of SARS‐CoV‐2 infection and COVID‐19 pathologyReview Article Published on 2020-07-192022-10-28 Journal: British Journal of Pharmacology [Category] COVID-19, SARS, [키워드] ACE2 acute respiratory distress animal animal model arising article caused Complication coronavirus disease COVID‐19 described disease drug dysregulated immune response Efficacy enzyme expressing ferrets hamsters Immunity immunopathology in vivo Infection involved macaques mechanism pandemic Pathogenesis pathology Pharmacology potential treatments progression Research SARS‐CoV‐2 SARS‐CoV‐2 infection syndrome Therapeutic approach transgenic mice Transmission Treatment Trial unmet need viral infection [DOI] 10.1111/bph.15143 PMC 바로가기 [Article Type] Review Article
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2 Research Published on 2020-06-092022-10-05 Journal: Nature [Category] SARS, 비임상, 임상, 진단, 치료제, [키워드] acute respiratory syndrome animal model animal models Antiviral approved authorization benefit Bronchoalveolar lavage clinical clinical benefit clinical trial coronavirus coronavirus disease COVID-19 drug effective Efficacy Emergency first dose food GS-5734 in vivo infected with SARS-CoV-2 Infection inhibited initiated investigated lack lung damage lung viral load macaque MERS-CoV Middle East nucleotide patients with COVID-19 Pneumonia potential treatments preclinical data Prevent progression pulmonary infiltrate reduced Remdesivir Replication Repurposed drug respiratory syndrome coronavirus rhesus rhesus macaque SARS-CoV-2 severe disease suggested Support therapy treat treated Treatment upper respiratory tract Virus shedding virus titre while [DOI] 10.1038/s41586-020-2423-5 [Article Type] Research