Genomic epidemiology of the Los Angeles COVID-19 outbreak and the early history of the B.1.43 strain in the USA로스앤젤레스 COVID-19 발병의 게놈 역학 및 미국 B.1.43 균주의 초기 역사Article Published on 2022-04-042022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Asia being Care carried caused collected coronavirus COVID-19 outbreak Critical determine effective Epidemiology Europe Evidence Genome Genome sequencing Health International investigation Los Angele Los Angeles mutations outbreak Outbreaks pandemic Patient powerful tool Prevent public health public health measure public health measures quantified response SARS-CoV-2 seeking sequencing method severe acute respiratory syndrome Coronavirus state strain Strains Surveillance sustained System Transmission transmission rate Travel unique University of California USA viral genome Viral genome sequencing viral genomes Viral transmission virus Washington while [DOI] 10.1186/s12864-022-08488-7 PMC 바로가기 [Article Type] Article
A novel unsupervised approach based on the hidden features of Deep Denoising Autoencoders for COVID-19 disease detectionResearch article Published on 2022-04-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] Accuracy affected Algorithm anomaly detection approach autoencoder build Chest comparison computed tomography (CT) Convolutional autoencoders Coronavirus disease 2019 COVID-19 COVID-19 disease CT scan deep Deep denoising autoencoder effective Effectiveness evaluated feature Feature learning greater hidden identify measure Metrics Patient Pneumonia powerful tool provided reliability robust statistical the disease threshold [DOI] 10.1016/j.eswa.2021.116366 [Article Type] Research article
Clathrin-nanoparticles deliver BDNF to hippocampus and enhance neurogenesis, synaptogenesis and cognition in HIV/neuroAIDS mouse model Research Published on 2022-03-172022-10-05 Journal: Communications Biology [Category] 바이오마커, [키워드] attribute BDNF Blood Blood brain barrier Brain brains Cell cell proliferation Concentration correlated decrease dendritic downstream Effect ENhance Express expression growth HIV intranasal intranasally memory neurons neurotoxic Newborn powerful tool promote Protein receptor reducing regenerative severity Signaling survival therapeutic tropomyosin [DOI] 10.1038/s42003-022-03177-3 [Article Type] Research
Multiphysics and multiscale modeling of microthrombosis in COVID-19Research Article Published on 2022-03-072022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, MERS, SARS, [키워드] activities Blood Blood coagulation blood flow blood sample Cell cell cluster circulating cell clinical evidence Cluster Coagulation coagulation factor component contribute Coronavirus disease 2019 COVID-19 Endothelial cell evaluated exacerbate Factor identify in vitro Inflammatory response leukocyte mechanism microthrombi microthrombus offer Patient patients with COVID-19 powerful tool Predictive progression prothrombotic provide Quantitative recruitment reported SARS-CoV-2 target the disease Therapeutic approach thrombosis thrombus formation Transport treating COVID-19 Treatment WBC [DOI] 10.1371/journal.pcbi.1009892 PMC 바로가기 [Article Type] Research Article
Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening고처리량 스크리닝 적용을 위한 안정적인 SARS-CoV-2 레플리콘 시스템 구축Article Published on 2022-03-012022-09-11 Journal: Antiviral Research [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antiviral Antiviral effect antiviral effects Bacterial bacterial artificial chromosome biosafety level Biosafety Level 3 BSL2 BSL3 camostat Cell cell line cell lines cells chromosome compounds condition conditions coronavirus COVID-19 examined exhibited Favipiravir gene encoding In vitro infection inhibited interferon level 3 luciferase luciferase activity molnupiravir Neomycin Novel coronavirus Particles powerful tool produced RdRP RdRp inhibitor Remdesivir Renilla Renilla luciferase replicon reported RNA SARS-coronavirus SARS-coronavirus-2 SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 sgRNA sgRNAs stable cell stable cell line suppressed the SARS-CoV-2 transient transfection transiently transfected Treatment VeroE6 cells Viral proteins viral replication [DOI] 10.1016/j.antiviral.2022.105268 PMC 바로가기 [Article Type] Article
Powerful CRISPR-Based Biosensing Techniques and Their Integration With Microfluidic PlatformsBioengineering and Biotechnology Published on 2022-02-232022-10-31 Journal: Frontiers in Bioengineering and Biotechnology [Category] COVID-19, [키워드] amplification Analysis biosensor Combination coronavirus disease costly COVID-19 CRISPR CRISPR/Cas systems Cycling Efficiency equipment healthcare integration isothermal amplification limitation microfluidic techniques New Nucleic acid detection outlined palindromic repeat PCR performed physiological temperature point-of-care powerful tool provide reducing Sensitivity and specificity specificity technique worldwide pandemic [DOI] 10.3389/fbioe.2022.851712 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
A cell-based system combined with flow cytometry to evaluate antibody responses against SARS-CoV-2 transmembrane proteins in patients with COVID-19코로나19 환자의 SARS-CoV-2 막관통 단백질에 대한 항체 반응을 평가하기 위해 유세포 분석과 결합된 세포 기반 시스템Article Published on 2022-02-222022-09-11 Journal: STAR protocols [Category] COVID19(2023년), SARS, 변종, [키워드] antibody Antibody Response Antibody responses approach Biology Cell Biology Cell-based Assays Complete Effectiveness evaluate Flow flow cytometry Flow Cytometry/Mass Cytometry glycosylation Health Sciences HEK293T cell HEK293T cells host cells insertion Laboratory membrane membrane protein Microbiology Molecular biology N-glycosylation patient sera patients with COVID-19 powerful tool protocol SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants transmembrane protein Vaccine viral infection [DOI] 10.1016/j.xpro.2022.101229 PMC 바로가기 [Article Type] Article
Recent Advances in the Development of Toll-like Receptor Agonist-Based Vaccine Adjuvants for Infectious DiseasesReview Published on 2022-02-162022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] accelerated Activation adaptive immune responses adjuvant adjuvants advance agonist Antigen boost COVID-19 pandemic development Diseases Effect effective efficient epidemic diseases Human Vaccines immune response immune responses inactive Infection Infectious disease innate immune responses microbial microbial infection molecular mechanism MPL mRNA vaccine nasal adjuvant pathogen pattern recognition receptor powerful tool PRR recent recognize Research Safe subsequent subunit target TLR TLR agonist TLRs Toll-like receptor Trigger Vaccine [DOI] 10.3390/pharmaceutics14020423 PMC 바로가기 [Article Type] Review
Recovery of SARS-CoV-2 from large volumes of raw wastewater is enhanced with the inuvai R180 systeminuvai R180 시스템으로 대량의 원폐수에서 SARS-CoV-2 회수가 향상됨Article Published on 2022-02-152022-09-11 Journal: Journal of environmental management [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis applicability approach average circulation Community complement Concentration coronavirus 2 diarrhea early stage early stages effective epidemic diarrhea Epidemiology evaluate evaluated favor feature fiber filtration glycol groups inhibitory limits Limits of detection Methods performance and evaluation microbial outbreak overcome PEDV percentage plant Polyethylene glycol powerful tool Prevalence protocol quantification required SARS-CoV-2 scalability Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 Surveillance Treatment Usage Variability viral concentrations virus Volume wastewater Wastewater-based epidemiology water [DOI] 10.1016/j.jenvman.2021.114296 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific T cells generated for adoptive immunotherapy are capable of recognizing multiple SARS-CoV-2 variantsResearch Article Published on 2022-02-142022-10-29 Journal: PLoS Pathogens [Category] COVID-19, COVID19(2023년), SARS, [키워드] alleles Allogeneic Anti-viral Antigen approach can be used Cell Complication convalescent individual Coverage COVID-19 Critical Effectiveness epitope Evidence expand functional generate healthy HLA HLA class I humans immune immune system Immunocompromised patient Immunotherapy increased risk individual leukocyte observation offer Patient phenotypic powerful tool provided recognize recognizing reduce remain unchanged Repository Research risk robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-specific T cell screened selected severe complication severe COVID-19 susceptible T cell T cells T-cell T-cell Response target transfer treat Treatment Vaccines variant variants of SARS-CoV-2 viral disease viral infections virus-specific T cell while with COVID-19 [DOI] 10.1371/journal.ppat.1010339 PMC 바로가기 [Article Type] Research Article