Dye-Loaded Polymersome-Based Lateral Flow Assay: Rational Design of a COVID-19 Testing Platform by Repurposing SARS-CoV-2 Antibody Cocktail and Antigens Obtained from Positive Human SamplesDye-Loaded Polymersome-Based Lateral Flow Assay: 양성 인간 샘플에서 얻은 SARS-CoV-2 항체 칵테일 및 항원을 용도 변경하여 COVID-19 테스트 플랫폼의 합리적인 설계Article Published on 2021-08-272022-09-11 Journal: ACS Sensors [Category] MERS, SARS, 진단, 치료기술, [키워드] addition Affinity chromatography Analysis analyzed antibody Antibody test antibody tests Antigen antigens applied blue cocktail Combination COVID-19 demonstrated Diagnosis diagnostic test diagnostic tests dye-loaded polymersome ELISA Flow gel electrophoresis global pandemic glycol highlight Human Human resources in vitro in vitro diagnostics Lateral lateral flow lateral flow assay lateral flow immunoassay mitigate mutations nasal swabs Perspective platform POC point-of-care point-of-care (POC) platform polyacrylamide polycaprolactone polymersome preparation Protein purified repeatability reproducibility repurposing resource RT-PCR Sample sample repurposing. SARS-CoV-2 sensitivity serum sodium sodium dodecyl sulfate specificity stability Testing the disease the preparation transmission rate were used widespread [DOI] 10.1021/acssensors.1c00854 PMC 바로가기 [Article Type] Article
Single‐dose immunisation with a multimerised SARS‐CoV‐2 receptor binding domain (RBD) induces an enhanced and protective response in mice다량체화된 SARS-CoV-2 수용체 결합 도메인(RBD)을 사용한 단일 용량 면역은 마우스에서 강화된 보호 반응을 유도합니다Research Letter Published on 2021-08-222022-09-12 Journal: Febs Letters [Category] MERS, 진단, [키워드] Analysis Antibody titre Antigen antigens Bacteria buffer caused complexes coronavirus COVID‐19 COVID‐19 defined demonstrated Dps elicited exclusion experiment expressed form health emergency highlight immunisation increase induce introduced lung mammalian cells mice Microscopy monomeric RBD neutralising antibody pandemic Particle PBS preparation Protective purified Quality control RBD Receptor binding domain SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 SDS spike Subunit vaccine triggered Vaccine viral clearance were expressed [DOI] 10.1002/1873-3468.14171 PMC 바로가기 [Article Type] Research Letter
Simple and Rapid Method for Wogonin Preparation and Its BiotransformationArticle Published on 2021-08-202022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, SARS, [키워드] Radix Scutellariae Scutellaria baicalensis activities anticancer baicalein baikal skullcap Biotransformation catalyzed Chinese complement COVID-19 determine effective exhibit glucoside glycosylation ingredient Isolation knowledge lack management Medicine metabolism microorganism microorganisms Phase I preparation provide Rapid Scutellaria baicalensis simple tested therapeutic therapeutic use was used were used wogonin [DOI] 10.3390/ijms22168973 PMC 바로가기 [Article Type] Article
Building a virtual summer research experience in cancer for high school and early undergraduate students: lessons from the COVID-19 pandemicResearch Published on 2021-08-092022-10-28 Journal: BMC Medical Education [Category] Coronavirus, MERS, SARS, [키워드] building Cancer Cancer center center Comprehensive COVID-19 pandemic curriculum development engage evaluate event expand experience feasible finding implementation include information Melvin Mentoring outcomes pandemic physically Pipeline program Population preparation public health recruitment reduction Research Research education resource Result Satisfaction scale School seamless social distancing suggested summer supplementary material Support unique university virtual education were measured [DOI] 10.1186/s12909-021-02861-y PMC 바로가기 [Article Type] Research
National and regional trends in MRI utilization in the face of the ongoing COVID-19 pandemic진행중인 COVID-19 전염병에 직면한 MRI 활용의 국가 및 지역 동향Original Research Article Published on 2021-07-152022-09-12 Journal: Israel Journal of Health Policy Research [Category] 진단, [키워드] accompanied activities adaptation Behavior change conducted COVID COVID-19 COVID-19 case COVID-19 cases COVID-19 disease COVID-19 pandemic database decrease demonstrated diagnostic disease distribution Effect explained First wave followed by healthcare help Jerusalem magnetic resonance imaging material Ministry of Health MRI National pandemic pattern Place of residence predict preparation rate ratio reduced reductions in Region regions residence Result return second wave sensor surgical Wave, Disparity, MRI exam Waves [DOI] 10.1186/s13584-021-00472-y PMC 바로가기 [Article Type] Original Research Article
SARS-CoV-2 Receptor Binding Domain as a Stable-Potential Target for SARS-CoV-2 Detection by Surface—Enhanced Raman Spectroscopy표면에 의한 SARS-CoV-2 검출을 위한 안정적-잠재적 표적으로서의 SARS-CoV-2 수용체 결합 도메인 - 강화된 라만 분광법Article Published on 2021-07-052022-09-10 Journal: Sensors (Basel, Switzerland) [Category] SARS, 치료기술, 치료제, [키워드] albumin antibody approach bovine serum albumin BSA Concentration detect detection Detection limit develop experiment Frequency open optical preparation Protein protein level Raman spectroscopy RBD RBD protein reported SARS-CoV-2 SARS-CoV-2 RBD protein SARS-COV-2 receptor binding domain selectivity sensitivity SERS shown silver/gold nanostructures Spectroscopy substrate substrates target the preparation virus viruses was obtained were used [DOI] 10.3390/s21134617 PMC 바로가기 [Article Type] Article
One-pot high-yield synthesis of Pd nanocubes for Pd-Ir nanocube-based immunoassay of nucleocapsid protein from SARS-CoV-2SARS-CoV-2로부터 뉴클레오캡시드 단백질의 Pd-Ir 나노큐브 기반 면역분석을 위한 Pd 나노큐브의 원팟 고수율 합성Article Published on 2021-07-012022-09-11 Journal: Analytical and bioanalytical chemistry [Category] SARS, 진단, 치료기술, 치료법, [키워드] applied catalytic activity Detection sensitivity Diagnosis equipment horseradish peroxidase human diseases immunoassay immunoassays involved magnitude nucleocapsid protein One-pot Pd nanocubes Pd-Ir nanocubes peroxidase preparation resulting SARS-CoV-2 significantly increased simplicity stability synthesis temperature the immunoassay the preparation [DOI] 10.1007/s00216-021-03265-z PMC 바로가기 [Article Type] Article
Feasibility of collecting and processing of COVID-19 convalescent plasma for treatment of COVID-19 in Uganda우간다에서 COVID-19 치료를 위한 COVID-19 회복기 혈장 수집 및 처리 가능성Research Article Published on 2021-06-172022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] accounted addressed African Antibody titer Antibody titers asked Blood blood collection blood donation CCP Community Consent convalescent plasma country COVID-19 cross-sectional cross-sectional study demonstrated Donor donors eligible Evidence evidence of feasibility female female gender greater increasingly Infection lack median age Nasopharyngeal swab nasopharyngeal swabs participant phobia plasma positive preparation processed processing randomized clinical trial Result retained SARS-CoV-2 testing screened statistically significant Stigma Support tested titers Transport Treatment treatment of COVID-19 Uganda was tested [DOI] 10.1371/journal.pone.0252306 PMC 바로가기 [Article Type] Research Article
Vaccine Hesitancy and Rejection of a Vaccine for the Novel Coronavirus in the United StatesImmunology Published on 2021-06-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] 95% confidence interval acceptance accompanied Adults age association characterized conducted COVID-19 COVID-19 vaccination COVID-19 vaccine demography disease outbreaks early phase effective Effectiveness Gender Hesitancy hypothetical less logistic regressions multivariable logistic regression novel participant Participants preparation profiles question rejection significantly more surveys and questionnaires the United State the vaccine Vaccine Vaccine hesitancy Vaccines [DOI] 10.3389/fimmu.2021.558270 PMC 바로가기 [Article Type] Immunology
Early Returns on Small Molecule Therapeutics for SARS-CoV-2SARS-CoV-2에 대한 저분자 치료제의 조기 수익Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] SARS, 신약개발, 치료제, [키워드] approach breadth clinical testing Computational approaches COVID-19 pandemic determine effort Extraordinary identify molecule Pandemics Potential treatment potential treatments preparation progression return SARS-CoV-2 SARS-COV-2 infection Scientific community small molecule Therapeutics treat [DOI] 10.1021/acsinfecdis.0c00874 PMC 바로가기 [Article Type] Article