HRPZyme Assisted Recognition of SARS-CoV-2 infection by Optical Measurement (HARIOM)광학 측정(HARIOM)을 통한 HRPZyme 지원 SARS-CoV-2 감염 인식Article Published on 2021-09-012022-09-11 Journal: Biosensors & bioelectronics [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antibody detection Antigen antigen tests assays colorimetric detection Concordance coronavirus COVID-19 detect diagnostics DNAZyme enzymatic assay genetic material Health Policies HRPZyme include Infection less mass Mass screening measurement molecular NAT NATs negative sample nucleic acid On-site diagnostics. PCR positive promise public health Recognition resource respiratory resulting robust Saliva SARS-CoV-2 SARS-COV-2 infection sensitivity Sensitivity and specificity severe acute respiratory syndrome Coronavirus specificity subjects to define Viral Viral protein Viral RNA while [DOI] 10.1016/j.bios.2021.113280 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Wastewater Surveillance for Public Health Action공중 보건 활동을 위한 SARS-CoV-2 폐수 감시Online Report Published on 2021-09-012022-09-10 Journal: Emerging Infectious Diseases [Category] SARS, 치료기술, [키워드] Action acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed applicability Community complement Concentration coronavirus coronavirus disease COVID-19 Disease surveillance Infection knowledge over pandemic promise provided Public public health quantification reported researcher respiratory respiratory infections Responder SARS-CoV-2 SARS-CoV-2 viral RNA SARS-CoV-2 wastewater surveillance severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown Surveillance translate Viral viruses wastewater zoonoses [DOI] 10.3201/eid2709.210753 PMC 바로가기 [Article Type] Online Report
Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-CoronavirusesSARS-CoV-2 및 Pan β-Coronavirus에 대한 향신료의 생물학적 활성 성분의 잠재적 면역 조절 특성Cellular and Infection Microbiology Published on 2021-08-272022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료제, [키워드] activity Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against alleviate Anti-inflammatory antioxidant antioxidants Antiviral antiviral properties bioactive components CCL2 cellular pathway cellular pathways chemokine Clinical outcome component contributing to coronavirus COVID-19 COVID-19 severity diet Effect elevated erythroid Health Health crisis Health Organization highlight HMOX1 homeostasis host cell host cell factor Host immune response host immune responses hypercytokinemia hyperinflammation IL6 IL8 immune responses Immunity inhibiting Interleukins lethality mediators modulate Multiorgan dysfunction Nrf2 nuclear oxidative oxidative stress Pan pathway Pneumonia Potential Prevent pro-inflammatory pro-inflammatory mediator pro-inflammatory mediators promise property PROTECT protective immunity respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus spice spices sustained systemic inflammation tissue damage TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variation World Health Organization β-Coronaviruses [DOI] 10.3389/fcimb.2021.729622 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge인간 세포 기반 SARS-CoV-2 백신은 강력한 중화 항체 반응을 유도하고 SARS-CoV-2 공격으로부터 마우스를 보호합니다Research Article Published on 2021-08-122022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration ameliorated Antibody titer approach caused Cell cell-based vaccines cellular convalescent serum coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated develop effective Efficacy elicit exposure to external gene external genes formalin generate greater hACE2 human cell immunization in viral inactivated Inactivated vaccine induce K562-S Log reduction lung Lung pathology membrane MERS-CoV mice mouse model NAb neutralizing antibody Neutralizing antibody response Neutralizing antibody titer non-human primate non-human primate model non-human primates pandemic platform promise PROTECT protection Protective Protein regimen respiratory response S-protein Safe SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 mutants SARS-CoV-2 vaccine severe acute respiratory syndrome Coronavirus spike Support turn vaccination Vaccine vaccine candidate vectors viability Viral X-ray [DOI] 10.1080/22221751.2021.1957400 PMC 바로가기 [Article Type] Research Article
Metatranscriptomic Characterization of Coronavirus Disease 2019 Identified a Host Transcriptional Classifier Associated With Immune Signaling코로나바이러스 질병 2019의 메타전사 특성화는 면역 신호와 관련된 숙주 전사 분류기를 확인했습니다Article Published on 2021-08-022022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway Alpha Analysis analyzed caused characteristics of patient characterization Classifier concurrent infection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 diagnosis COVID-19 patient COVID-19 patients cytokine signaling diagnosing Diagnosis differentially expressed gene Differentially expressed genes disease severity elements evaluated examined exhibited gene analysis Host host gene Host immune response host responses Identified immune pathways Infection Interferon-gamma metatranscriptomic metatranscriptomics. microbe Microbiome Non-COVID-19 Novel coronavirus outbreak pandemic pathogenic Pathogens Pathways Patient Pneumonia pneumonias promise reduced respiratory illnesses respiratory viruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling significantly transcriptional with COVID-19 [DOI] 10.1093/cid/ciaa663 PMC 바로가기 [Article Type] Article
Hepatitis C Diagnosis: Simplified Solutions, Predictive Barriers, and Future PromisesReview Published on 2021-07-132022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Algorithm Analysis approval assays Blood Care cascade clinical experience country Diagnosis diagnostic dried blood spot Future HCV HCV core antigen HCV elimination Health Hepatitis hepatitis C hepatitis C diagnosis hepatitis C-self testing highlight identify individuals measure modulating Nucleic acid amplification technologies one-step screening overcome platform POC point-of-care test Population promise public health Rapid diagnostic test Rapid diagnostic tests reflex RNA testing RNA Treatment WHO’ [DOI] 10.3390/diagnostics11071253 PMC 바로가기 [Article Type] Review
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques2개의 강력한 중화 항체 조합을 통한 조기 치료는 SARS-CoV-2에 감염된 원숭이에서 임상 결과를 개선하고 바이러스 복제 및 폐 염증을 감소시킵니다.Research Article Published on 2021-07-062022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, 진단, [키워드] 24 hour 24 hours animal animals anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies antibody antibody combination clinic clinical development Clinical outcome Clinical signs Clinical studies clinical testing Combination combinations controls COVID-19 COVID-19 disease develop dose early infection effective extension group half-lives High dose high risk histology Human IMPROVE infected individual Infection inoculated interstitial pneumonia intra-tracheally intranasally intravenously investigated less Lower respiratory tract lung Lung inflammation macaque maintain monoclonal antibodies monoclonal antibody mutations neutralize neutralizing antibody neutralizing monoclonal antibodies Placebo progression promise Prophylactic provide reduce reduced respiratory respiratory tract rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease shown significantly Support tested therapeutic efficacy therapeutic intervention Therapeutic strategies three groups treated Treatment upper and lower respiratory tract variant Viral Viral variants virus replication [DOI] 10.1371/journal.ppat.1009688 PMC 바로가기 [Article Type] Research Article
Structure-based Design of a Specific, Homogeneous Luminescence Enzyme Reporter Assay for SARS-CoV-2SARS-CoV-2에 대한 특정 균질 발광 효소 리포터 분석의 구조 기반 설계Article Published on 2021-06-252022-09-11 Journal: Journal of Molecular Biology [Category] MERS, SARS, 진단, 치료기술, [키워드] antibody applied assays binding C-terminal catalytic activity complementary Complementation COVID-19 detectable develop diagnostic enzyme epitope Epitopes Express Gaussia Luciferase high affinity Incubation luciferase other diseases pathogenic PCA promise Protein protein-fragment complementation assay recombinant recombinant antibodies reporter reporters S-protein SARS CoV SARS CoV-2 SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 virus sensitivity Specific specificity spike spike (S) protein steric the SARS-CoV-2 virus threat Treatment Trimers Viral viral spike Virus-like particle virus-like particles [DOI] 10.1016/j.jmb.2021.166983 PMC 바로가기 [Article Type] Article
The Promise of Disease Detection Dogs in Pandemic Response: Lessons Learned From COVID-19Concepts in Disaster Medicine Published on 2021-06-082022-10-31 Journal: Disaster Medicine and Public Health Preparedness [Category] COVID-19, [키워드] changed contribute coronavirus disease COVID-19 COVID-19 infection detection disease dog Effectiveness effort Evidence feasibility flexible implementation knowledge lesson noninvasive pandemic Policy promise public health Public health intervention required Research resource Scent detection dogs screening method Spread Support the United State trajectory utility [DOI] 10.1017/dmp.2021.183 PMC 바로가기 [Article Type] Concepts in Disaster Medicine
The Promise of AI in Detection, Diagnosis, and Epidemiology for Combating COVID-19: Beyond the HypeArtificial Intelligence Published on 2021-05-142022-10-31 Journal: Frontiers in Artificial Intelligence [Category] COVID-19, [키워드] accelerate addressed affecting Algorithm alleviate artificial intelligence Care Chest CT clinician combating Contact tracing coronavirus COVID-19 COVID-19 pandemic deaths detection diagnose diagnosing Diagnosis Disease diagnosis epidemiological Epidemiology Government healthcare Healthcare system high mortality highlighting identify Impact implementation lack Medical imaging mortality rate Other outcome pandemic Pandemics Patient patient hospitalization problem promise recent Regulatory Research risk Science Social control Spread the disease train model translation X-ray [DOI] 10.3389/frai.2021.652669 PMC 바로가기 [Article Type] Artificial Intelligence