protein structure – Page 4 – Communicable Diseases Research

Updated SARS-CoV-2 single nucleotide variants and mortality association

업데이트된 SARS-CoV-2 단일 뉴클레오티드 변이체 및 사망률 연관성

Article

Published on 2021-12-012022-09-11
Journal: Journal of medical virology [Category] SARS, 변종, 진단,

In depth analysis of Cyprus-specific mutations of SARS-CoV-2 strains using computational approaches

계산 접근법을 사용하여 SARS-COV-2 균주의 키프로스-특이 적 돌연변이의 깊이 분석

Research

Published on 2021-11-132022-09-10
Journal: BMC Genomic Data [Category] MERS, SARS, 변종,

[키워드] Alter Amino acid Analysis appear association can not changes in computational approach Computational approaches conformational change Course Cyprus-specific mutations death depth analysis Frequency generate genetic data GISAID indication information lead Linear regression Linear regression model linear regression models Mutation National nucleotide nucleotide position ORF1ab gene pandemic Prevalence prevalent Protein protein structure public health Regression model regression models Result SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 strain SARS-CoV-2 strains selective sequence significantly single mutation specific mutations statistical analysis Structural prediction supplementary material the SARS-CoV-2 unique Viral viral pathogenicity Viral virulence
[DOI] 10.1186/s12863-021-01007-9 PMC 바로가기 [Article Type] Research

Exposing structural variations in SARS-CoV-2 evolution

SARS-CoV-2 진화의 구조적 변이 노출

Article

Published on 2021-11-112022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 변종,

[키워드] ACE2 acute disease Affect affinity aligned Alpha Alpha variant Analysis B.1.1.7 B.1.617.2 conformational change conformations contributed coronavirus Course Critical delta variant disease effective Effectiveness Evolution function human cells integration lack Lineage Lineage B.1.1.7 Mutation mutations Physicochemical properties physicochemical property physiochemical property Protein protein sequence protein structure residue SARS-CoV SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variants Spike protein Structural analysis structural biology Structural variation structural variations Structure structures the SARS-CoV-2 Vaccine variant Viral viral infection virus Virus evolution
[DOI] 10.1038/s41598-021-01650-3 PMC 바로가기 [Article Type] Article

Binding of boswellic acids to functional proteins of the SARS-CoV-2 virus: Bioinformatic studies

SARS-CoV-2 바이러스의 기능성 단백질에 대한 보스웰산의 결합: 생물정보학 연구

Article

Published on 2021-11-012022-09-11
Journal: Archiv der Pharmazie [Category] SARS, 치료제,

[키워드] acetyl active site adhesion Amino acid amino acids antiviral activity binding binding affinity binding energy Bioinformatic bioinformatics boswellic acids complex disease docked drug Effectiveness functional functional protein functional proteins impacted M pro market metabolite molecular docking negative and positive nucleoprotein occurred phosphate phosphorylated polyprotein positive Protein protein structure proteinase RdRP Replication responsible RGS-P3 RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 virus shown spike glycoprotein the SARS-CoV-2 the SARS-CoV-2 virus treat was tested
[DOI] 10.1002/ardp.202100160 PMC 바로가기 [Article Type] Article

Role of “dual-personality” fragments in HEV adaptation—analysis of Y-domain region

Research

Published on 2021-10-122023-08-30
Journal: Journal of Genetic Engineering & Biotechnology [Category] E형 간염,

[키워드] molecular function Nucleotide-binding propensity Phosphorylation Protein disorder protein structure Protein-binding propensity Y-domain region (YDR)
[DOI] 10.1186/s43141-021-00238-8 PMC 바로가기 [Article Type] Research

A Bioinformatics Approach for the Prediction of Immunogenic Properties and Structure of the SARS-COV-2 B.1.617.1 Variant Spike Protein

면역 원성 특성의 예측 및 SARS-COV-2의 구조 B.1.617.1 변이 스파이크 단백질의 생물 정보학 접근법

Research Article

Published on 2021-10-052022-09-10
Journal: BioMed Research International [Category] 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Amino acid amino acid sequence Analysis analyzed Antigen antigenic B cell B cell epitopes B- and T-cell epitopes B.1.617.1 bioinformatics chemokine Coronavirus-2 COVID-19 drug Epitopes IFN immune function immunogenic Immunological response immunological responses in silico analysis in silico Approach incidence interferon Interferon-gamma mitigate Mortality objective predicted prediction property Protective Protein protein structure provide Region respiratory Respiratory illness responsible Result S protein S protein of SARS-CoV-2 SARS-CoV 2 SARS-CoV-2 second wave sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 spike Structure subunit T cell T cell epitope T cell epitopes T-cell epitopes tertiary structure Vaccine variant variant of SARS-CoV-2 variant S protein was used
[DOI] 10.1155/2021/7251119 PMC 바로가기 [Article Type] Research Article

Temporal landscape of mutational frequencies in SARS-CoV-2 genomes of Bangladesh: possible implications from the ongoing outbreak in Bangladesh

방글라데시 SARS-CoV-2 게놈의 돌연변이 빈도의 시간적 풍경: 방글라데시에서 진행 중인 발병의 가능한 의미

Article

Published on 2021-10-012022-09-11
Journal: Virus Genes [Category] SARS, 변종, 치료기술, 치료법, 치료제,

[키워드] age Analysis association Bangladesh change circulating condition conserved country COVID-19 D614G D614G mutation envelope envelope protein Evolution facilitate Factor Frequency function Genome GISAID Helicase implication intrinsic majority Model molecular phylogeny Mutation N protein nonspecific NSP11 NSP2 Nsp3 Nsp9 nucleocapsid protein ORF ORF3a ORF7b outbreak P323L performed platform Protein protein structure RdRP reference genome S2 domain SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomic sequence SARS-CoV-2 genomic sequences SARS-CoV-2 propagation SARS-CoV-2 strain selective sequenced Sex Spike protein strain susceptibility Temporal the Spike unique Vaccine development
[DOI] 10.1007/s11262-021-01860-x PMC 바로가기 [Article Type] Article

An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15

Research Article

Published on 2021-09-232022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS,

[키워드] 5′-UTR Applying binding complex coronavirus CTD, C-terminal domain docking dsRNA EndoN, endonuclease exonuclease function generate GTase, guanylyltransferase indicate involved MD, molecular dynamics MHV, murine hepatitis virus molecular Molecular modeling mRNA mRNA transcripts MST, microscale thermophoresis MTase, methyltransferase N, nucleocapsid nsp, nonstructural viral protein nsp13 nsp14 Nsp15 NTD, N-terminal domain NTPase, nucleoside triphosphatase nucleocapsid polymerase Proofreading Protein protein structure question recruit Replication replication-transcription complex responsible RNA RTC, replication-transcription complex SARS-CoV-2 Structure structure model subunit switching Transcription trimer TRS-B, body TRS TRS-L TRS-L, leader TRS TRS, transcription regulatory sequence viral genome Viral protein viral replication Viral RNA viral transcription while
[DOI] 10.1016/j.jbc.2021.101218 PMC 바로가기 [Article Type] Research Article

Receptor binding, immune escape, and protein stability direct the natural selection of SARS-CoV-2 variants

Research Article

Published on 2021-09-172023-06-15
Journal: The Journal of Biological Chemistry [Category] MERS, SARS,

Partial protection of Sinopharm vaccine against SARS COV2 during recent outbreak in Bahrain

최근 바레인에서 발생한 SARS COV2에 대한 Sinopharm 백신의 부분적 보호

Article

Published on 2021-09-012022-09-11
Journal: Microbial pathogenesis [Category] SARS, 치료기술,