proteolytic cleavage
[용어속성] Action
Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones
COVID-19의 성별 차이: 후보 경로, ACE2의 유전학 및 성 호르몬
Review
[키워드] ACE2
Activation
ADAM17
added
angiotensin
Angiotensin-converting enzyme
angiotensin-converting enzyme 2
antiviral response
Biological
canonical
cardiovascular disease
caused
contribute
coronavirus
COVID-19
COVID-19 pandemic
Critical
dependent on
disease
disease pathogenesis
disease severity
disintegrin
epidemiological data
exacerbate
female
females
Gender
genetics
Health
highlight
increase in
increasingly
innate immune response
innate immune system
involved
leads
Loss
male
mechanism
membrane
metalloproteinase
Mortality
outcomes
Pathways
plasma
positive
positive feedback
potential mechanism
potential mechanisms
protective mechanism
proteolytic cleavage
RAS
receptor
Renin
renin-angiotensin system
SARS epidemic
SARS-CoV-2
SARS-CoV-2 coronavirus
SARS-COV-2 infection
severe disease
Sex
sex differences
sex hormone
Sex hormones
susceptibility
the SARS-CoV-2
Viral
viral entry
worsened
[DOI] 10.1152/ajpheart.00755.2020 PMC 바로가기 [Article Type] Review
[DOI] 10.1152/ajpheart.00755.2020 PMC 바로가기 [Article Type] Review
Design, Expression, Purification, and Characterization of a YFP-Tagged 2019-nCoV Spike Receptor-Binding Domain Construct
Bioengineering and Biotechnology
[키워드] 2019-nCoV
2019-nCoV spike protein
2019-nCoV spike-RBD production using standard cell culture equipment and techniques
ACE2
adherent cell
Analysis
Antigen
assays
binding
C-terminal
Cell
cells
characterization
cleavage site
coronavirus disease
COVID-19
disulfide bond
domain
experiment
expression
FLAG-tag
fluorescent
fluorescent spike RBD fusion protein
fusion protein
human Angiotensin-converting enzyme
Human rhinovirus
IFNα2
immunization
in vitro
include
Interferon alpha
labeling
mammalian protein secretion
Microscopy
N-linked glycosylation
N-terminal
Ni-NTA
pandemic
produced
protease
Protein
protein reagent for COVID-19 research
proteolytic cleavage
protocol
purification
RBD
receptor
required
Research
SDS-PAGE
SEC
secreted
secreted glycosylated YFP-labeled protein
secreted protein
secretion
serum-free medium
signal peptide
spike
staining
the RBD
Vaccine
virus
YFP-spike_RBD
[DOI] 10.3389/fbioe.2020.618615 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
[DOI] 10.3389/fbioe.2020.618615 PMC 바로가기 [Article Type] Bioengineering and Biotechnology
SARS-CoV-2, Early Entry Events
Review Article
[키워드] ACE2
ACE2 receptor
acting
addition
appear
binding affinity
Cell
cell type
cleavage
cleavage sites
competent
complex
conformational change
conserved
COVID-19
crown
dependent on
element
furin
fusion peptide
host cell
host tissue
identification
immune function
insertion
membrane
membrane fusion
membranes
occur
parasites
protease
Protein
proteolytic cleavage
Proteolytic processing
RBM
receptor
receptor-binding motif
replication efficiency
S protein
SARS-CoV-2
SARS-CoV-2 S
serine 2
serine protease
spike
susceptible
transmembrane
viral life cycle
virus
[DOI] 10.1155/2020/9238696 PMC 바로가기 [Article Type] Review Article
[DOI] 10.1155/2020/9238696 PMC 바로가기 [Article Type] Review Article
Generation of Chicken IgY against SARS-COV-2 Spike Protein and Epitope Mapping
Research Article
[키워드] 3D structure
acute respiratory syndrome
administration
antibody
Antibody binding
approved drugs
caused
chicken
clinician
coronavirus
COVID-19
cross-reactive
enzyme
epitope
epitope mapping
Epitopes
exhibited
feasibility
FIVE
Generation
global pandemic
Health
immune responses
immunization
Immunoglobulin
immunoreactivity
include
intranasal
linear epitope
Local
mapping
neutralizing antibody
overlap
physically
Protein
proteolytic
proteolytic cleavage
raised
repurposing
respiratory infections
risk
S trimer
S1/S2
S1/S2 cleavage
S1/S2 cleavage site
SARS-CoV S
SARS-CoV-2
SARS-CoV-2 S
scientist
spike
subsequent
Therapeutic approach
therapy
treating SARS-CoV-2 infection
Vaccine
viral cell
virus-cell membrane fusion
[DOI] 10.1155/2020/9465398 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1155/2020/9465398 PMC 바로가기 [Article Type] Research Article
Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoprotein
Article
[키워드] ab initio modelling
abrogated
Abstract
cleavage site
conformations
coronavirus
furin cleavage site
glycan
host cells
human pathogen
insertion
Interaction
Molecular dynamics simulation
prefusion
protease
proteolytic cleavage
regulate
representing
S1/S2
SARS-CoV-2
spike glycoprotein
spike glycoprotein gene
Structure
the SARS-CoV-2
therapeutic target
viral entry
virulent
[DOI] 10.1016/j.yjsbx.2020.100038 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.yjsbx.2020.100038 PMC 바로가기 [Article Type] Article
The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases
Research Article
[키워드] 229E
activated
applied
binding
Cathepsins
CD81
CD9
Cell
cell entry
cell lines
cell membranes
cellular receptors
cleaved
Clustering
co-expressed
complex
complexes
coronavirus
CoV
CoV infection
CoVs
demonstrated
Dipeptidyl peptidase 4
DPP4
endosome
evaluate
Evolution
Express
facilitate
facilitated
Gene Expression
host cell receptor
human CoV
human DPP4
in vivo
Infection
infections
initiate
interactions
less
Lungs
membrane
membrane fusion
MERS-CoV
MERS-CoV entry
MERS-CoV infection
MERS-CoV pseudovirus
mice
Pathogens
pathway
promote
protease
Proteases
Protein
protein complex
proteolytic cleavage
receptor
recombinant adenovirus
robust
S proteins
selective
significantly
small RNA
susceptible
the S protein
TMPRSS2
transducing
transmembrane protein
transmembrane serine protease
TTSP
TTSPs
vector
vectors
viral spike
virulence
virulent
virus
virus entry
virus infection
virus-cell membrane fusion
[DOI] 10.1371/journal.ppat.1006546 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1006546 PMC 바로가기 [Article Type] Research Article
Nucleocapsid Interacts with NPM1 and Protects it from Proteolytic Cleavage, Enhancing Cell Survival, and is Involved in PEDV Growth
Article
[키워드] activities
addition
binding
caspase-3
Cell
components
cytoplasm
Degradation
ENhance
Enhancing
epidemic diarrhea
growth
host cell
independent
indicated
infected cells
interact
Interaction
knockdown
mechanism
N protein
NPM1
nuclear translocation
nucleocapsid
Nucleolus
nucleophosmin
nucleus
overexpression
PEDV
Prevent
promoted
PROTECT
Protein
proteolytic
proteolytic cleavage
Regulation
replicate
Replication
required
suppressed
survival
the N protein
virus
[DOI] 10.1038/srep39700 PMC 바로가기 [Article Type] Article
[DOI] 10.1038/srep39700 PMC 바로가기 [Article Type] Article
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner
Research Article
[키워드] Cell
cell entry
Clathrin-mediated endocytosis
cleavage
conformational change
coronavirus
CoV
CoVs
demonstrated
endocytosed
endosomal maturation
endosomal pH
entry pathway
expressing
furin
furin cleavage site
fusion
fusion peptide
fusion protein
gene silencing
Genome
Host
host cell
host cell membrane
induce
Infection
influenza A virus
inhibited
introduced
investigated
late endosomes
less
lysosomal protease
lysosomal proteases
lysosome
membrane fusion
MERS
MERS-CoV
MHV
microenvironment
mouse hepatitis
murine hepatitis virus
negatively affected
occur
pathogen
plasma membrane
predicted
previous study
promote
protease
Protease inhibitor
Protein
proteolytic cleavage
Proteolytic processing
reporter
required
S protein
shown
siRNA
Specific
the S protein
upstream
vesicular stomatitis virus
virus
while
zoonotic
[DOI] 10.1371/journal.ppat.1004502 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1004502 PMC 바로가기 [Article Type] Research Article