Proteomic analysis – Page 4 – Communicable Diseases Research

Proteomic analysis of chicken bone marrow-derived dendritic cells in response to an inactivated IBV + NDV poultry vaccine

Article

Published on 2021-06-162022-10-29
Journal: Scientific Reports [Category] Coronavirus,

Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection

단백질체 분석은 RNA 헬리카제 DDX3X를 SARS-CoV-2 감염에 대한 숙주 표적으로 식별합니다.

Article

Published on 2021-06-012022-09-11
Journal: Antiviral Research [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료제,

[키워드] accumulate aggregate antiviral drugs antiviral therapeutics cellular characterization COVID-19 cytoplasmic DDX3X DEAD RNA helicase develop eIF2α foci G3BP1 granules Health Helicase Host host protein host proteins Host-directed therapies identify infected cell infected cells infected Vero E6 cells Infection involved life cycle metabolism mitigate nucleoprotein Phosphorylation powerful tool Protein proteomic Proteomic analysis proteomics reduce Replication required ribonucleoprotein RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 replication scaffold proteins significantly small interfering RNAs small molecule Small molecules Stress stress granule stress granules Structure the SARS-CoV-2 Therapeutic strategies therapeutic strategy translation upstream Vero E6 VERO E6 cells Viral viral replication Viral RNA virus viruses
[DOI] 10.1016/j.antiviral.2021.105064 PMC 바로가기 [Article Type] Article

Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation

결함 있는 NET 제거는 COVID-19 관련 폐 혈전 염증에서 지속적인 FXII 활성화에 기여합니다

Research paper

Published on 2021-05-142022-09-11
Journal: EBioMedicine [Category] 유전자 메커니즘,

[키워드] accumulation Activation activity alveolar alveolar spaces Analysis clearance clinical Coagulation coagulation factor Coagulopathy Contact contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNase Donor European expression Extracellular factor XII FIBRIN finding foundation funding FXII hallmark hallmarks Hamburg healthy control immunostaining in vitro increased mortality Inflammation leads lung lung parenchyma lung tissue mechanism NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps offer pathogenic Pathologies Patient performed plasma sample plasma samples procoagulant Proinflammatory response proteomic Proteomic analysis Pulmonary thrombo-inflammation reduced Support supported sustained targeting therapeutic strategy thrombosis union vasculature was increased
[DOI] 10.1016/j.ebiom.2021.103382 PMC 바로가기 [Article Type] Research paper

Multi-organ proteomic landscape of COVID-19 autopsies

COVID-19 부검의 다기관 단백질 구조

Clinical Trial

Published on 2021-02-042022-09-11
Journal: Cell [Category] Fulltext, MERS, 유전자 메커니즘, 임상, 진단, 치료기술,

Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity

인간 ACE2 결합 친화도가 변경된 SARS-CoV2 스파이크 단백질의 돌연변이를 설명하는 진화적 및 구조적 분석

Article

Published on 2021-01-292022-09-11
Journal: Biochemical and Biophysical Research Communication [Category] 변종,

[키워드] ACE2 ACE2 binding affinity Alter Analysis analyzed binding binding affinity binding energy binding free energy docking Efficacy ENhance evaluate facilitate FIVE free energy Free energy calculations G476S glycoprotein host cell human ACE2 hydrogen Hydrogen bond identify Mutation pandemic Population Population variants Positive selection Proteomic analysis RBD RBD variant RBD variants RBD-ACE2 Receptor-binding domain Recognition reduced residue reveal SARS-CoV2 SARS-CoV2 genome Selection Selection bias spike spike glycoprotein Spike protein spike variant Structural analysis the RBD the receptor-binding domain V367F V483A variant variations while Wuhan
[DOI] 10.1016/j.bbrc.2021.01.035 PMC 바로가기 [Article Type] Article

Altered high-density lipoprotein composition and functions during severe COVID-19

심각한 COVID-19 동안 변경된 고밀도 지단백질 구성 및 기능

Article

Published on 2021-01-272022-09-10
Journal: Scientific Reports [Category] 유전자 메커니즘,

[키워드] Admission affecting Alpha Altered amyloid A Analysis Anti-inflammatory antioxidant antitrypsin Apolipoprotein Apoptosis Biomarkers cadherin changes in conditions consequence controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Day Decreased Endothelial cell endothelial cells exposure to function HDL HDL-C HDLs healthy subjects high-density initial intensive care intensive care unit less lipid metabolism mass spectrometry pandemic Particle Patient patients worldwide permeability plasma Protective Protein proteome Proteomic analysis proteomics pulmonary damage reported SARS-CoV-2 serum amyloid severe COVID-19 severe COVID-19 patient severe COVID-19 patients Sex TNFα VE-cadherin viral infection was performed
[DOI] 10.1038/s41598-021-81638-1 PMC 바로가기 [Article Type] Article

Dissecting the contribution of O-Antigen and proteins to the immunogenicity of Shigella sonnei generalized modules for membrane antigens (GMMA)

Shigella sonnei의 막 항원에 대한 일반화 모듈(GMMA)의 면역원성에 대한 O-항원과 단백질의 기여 분석

Article

Published on 2021-01-132024-07-30
Journal: Burma Med J [Category] 세균성이질,

[키워드] Biochemistry carbohydrates Diseases Immunological techniques Infectious diseases Isolation, separation and purification mass spectrometry Molecular engineering Proteomic analysis
[DOI] 10.1038/s41598-020-80421-y PMC 바로가기 [Article Type] Article

Evolutionary and structural analysis elucidates mutations on SARS-CoV2 spike protein with altered human ACE2 binding affinity

인간 ACE2 결합 친화도가 변경된 SARS-CoV2 스파이크 단백질의 돌연변이를 설명하는 진화적 및 구조적 분석

Article

Published on 2021-01-012022-09-11
Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종,

[키워드] ACE2 ACE2 binding affinity Alter Analysis analyzed binding binding affinity binding energy binding free energy docking Efficacy ENhance evaluate facilitate FIVE free energy Free energy calculations G476S glycoprotein host cell human ACE2 hydrogen Hydrogen bond identify Mutation pandemic Population Population variants Positive selection Proteomic analysis RBD RBD variant RBD variants RBD-ACE2 Receptor-binding domain Recognition reduced residue reveal SARS-CoV2 SARS-CoV2 genome Selection Selection bias spike spike glycoprotein Spike protein spike variant Structural analysis the RBD the receptor-binding domain V367F V483A variant variations while Wuhan
[DOI] 10.1016/j.bbrc.2020.11.075 PMC 바로가기 [Article Type] Article

In-depth blood proteome profiling analysis revealed distinct functional characteristics of plasma proteins between severe and non-severe COVID-19 patients

심층 혈액 프로테옴 프로파일링 분석은 중증 코로나19 환자와 그렇지 않은 COVID-19 환자 사이에서 혈장 단백질의 뚜렷한 기능적 특성을 밝혀냈습니다.

Article

Published on 2020-12-292022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 바이오마커,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Biomarker Blood Candidates Characteristics Clinical outcome complement Complement activation coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical case critical cases develop differentially expressed disease severity downstream eight Factor functional highlighting host response IMPROVE Infectious diseases interleukin interleukin-6 mortality rate Necrosis neutrophil neutrophil activation Patient patients worldwide performed plasma plasma protein Platelet potential therapeutic target potential therapeutic targets predict profiling analysis Prognosis prognostic biomarker Prognostic markers proinflammatory Protein Proteins proteome proteomic Proteomic analysis proteomics quantified reported respiratory SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severity of COVID-19 Support T cell Tumor tumor necrosis tumor necrosis factor upstream
[DOI] 10.1038/s41598-020-80120-8 PMC 바로가기 [Article Type] Article

Establishing a mass spectrometry-based system for rapid detection of SARS-CoV-2 in large clinical sample cohorts

Article

Published on 2020-12-032022-10-04
Journal: Nature Communications [Category] SARS, 바이오마커, 변종,