Modeling the epidemiological impact of the UNAIDS 2025 targets to end AIDS as a public health threat by 2030Research Article Published on 2021-10-182022-10-29 Journal: PLoS Medicine [Category] Coronavirus, MERS, SARS, [키워드] accelerate AIDS applied build checked contributed country Coverage COVID-19 creating cumulative death deaths declining Effect effort eliminating Epidemic epidemiological estimate expired Gender global analysis global effort Goal Health HIV HIV infection HIV/AIDS Impact include Infection infections Intervention intervention effect limitation mathematical Model modeling OPTIMA PLHIV populations Progress public health threat reduce reducing regions required researcher resource Result selected Support Surveillance target targets Treatment treatment interventions with HIV [DOI] 10.1371/journal.pmed.1003831 PMC 바로가기 [Article Type] Research Article
Perceptions of risk for COVID-19 among individuals with chronic diseases and stakeholders in Central Appalachia Research Published on 2021-10-072022-10-05 Journal: Humanities & Social Sciences Communications [Category] 치료기술, 치료법, [키워드] actual actual risk Administered Appalachia approaches association Cancer chronic condition chronic disease chronic obstructive Community Coronavirus disease 2019 COVID-19 curtail dependent on diabetes disease effective evaluate Gender Generalized greater Health hypertension indicate individual lack likelihood Model pandemic participant Patient Perceived risk Perception Prevent public health threat pulmonary disease questionnaire risk significantly spread of COVID-19 were used [DOI] 10.1057/s41599-021-00906-7 [Article Type] Research
The proximal proteome of 17 SARS-CoV-2 proteins links to disrupted antiviral signaling and host translation17개의 SARS-CoV-2 단백질의 근위 프로테옴은 항바이러스 신호 전달 및 숙주 번역을 방해합니다.Research Article Published on 2021-10-012022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] Activation antiviral signaling association atlas Card cleavage complex coronavirus Coronaviruses COVID-19 severity CWC22 database Factor FANCD2 Fluorescence functional Host host protein host proteins human cell human protein identify IFNB1 Impact inhibited inhibitor innate immune interferon signaling M protein MAVS membranes nsp1 nsp5 ORF6 Pathogenesis pathogenic coronavirus pathogenic mechanism pathogenic mechanisms pathogenicity peptide peptide sequences promote promoter protease Protein protein translation Proteins proteome proteomics proximal public health threat regulator Regulatory resource RIG-I SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 viral sequence Signaling subcellular target the SARS-CoV-2 translation translation initiation Transport TRIM4 variant Viral Viral protein Viral proteins [DOI] 10.1371/journal.ppat.1009412 PMC 바로가기 [Article Type] Research Article
Effect of ORF7 of SARS-CoV-2 on the Chemotaxis of Monocytes and Neutrophils In VitroResearch Article Published on 2021-09-282022-10-31 Journal: Disease Markers [Category] COVID-19, SARS, [키워드] A549 A549 cell acute respiratory syndrome caused CCL2 Cell chemokine chemotaxis component coronavirus Coronavirus disease 2019 COVID-19 Cytokine storm demonstrated Effect exacerbate examined expression Frame function Genome IL-6 IL-8 Immune cell immunological change Infection infiltration local inflammation lung Lung inflammation monocyte Monocytes Neutrophils ORF pathogenesis of COVID-19 Pneumonia promote public health threat recruit recruitment reduced SARS-CoV-2 severe COVID-19 Specific specific effect suggested the SARS-CoV-2 virus tissue Type II pneumocyte [DOI] 10.1155/2021/6803510 PMC 바로가기 [Article Type] Research Article
A novel model of care for simplified testing of HBV in African communities during the COVID-19 pandemic in Spain스페인의 Covid-19 Pandemic 동안 아프리카 공동체에서 HBV의 단순화 된 테스트를위한 새로운 관리 모델Article Published on 2021-08-252022-09-01 Journal: Scientific Reports [Category] B형 간염, MERS, 진단, 치료기술, [키워드] African Barcelona blood sample Blood samples Care chronic hepatitis Chronic Hepatitis B clinical history collected Community COVID-19 pandemic demonstrated Descriptive statistics diagnose diagnostic effort Epidemiology Evidence evidence of followed by HBsAg HBV Health services hepatitis B Hepatitis B virus identify Infection linkage offered Patient plasma separation point-of-care Population Prevalence public health threat Rapid Rapid tests receive required resolved returned Screening Spain specialist study participant targets the WHO vaccinate vaccination Viral hepatitis virus were used [DOI] 10.1038/s41598-021-96350-3 PMC 바로가기 [Article Type] Article
Potent prophylactic and therapeutic efficacy of recombinant human ACE2-Fc against SARS-CoV-2 infection in vivoArticle Published on 2021-08-122022-10-04 Journal: Cell Discovery [Category] 변종, 치료제, [키워드] ACE2 ACE2-Fc addition antiviral effects B.1.1.7 B.1.351 B.1.617.1 B.1.617.2 Beta bind blocked catalytic activity caused COVID-19 pandemic D614G Delta dose-dependent efficacy entry of SARS-CoV-2 enzyme escape mutants functional fusion protein hACE2 hACE2-expressing cell HCoV-NL63 histological changes immunology in vivo indicated induce infections Inflammation inhibited Lungs Mechanisms of disease mice mutant mutations neutralized Neutralizing antibodies potent Prophylactic prophylactic treatment Prophylaxis Protein provided public health threat RBD receptor Receptor binding domain reduced SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variants soluble ACE2 therapeutic therapeutic efficacy therapy for COVID-19 Treatment V367F viral replication weight loss [DOI] 10.1038/s41421-021-00302-0 PMC 바로가기 [Article Type] Article
The trans-omics landscape of COVID-19COVID-19의 트랜스오믹스 환경Article Published on 2021-07-272022-09-10 Journal: Nature Communications [Category] 바이오마커, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, [키워드] Analysis Antimicrobial responses arginine arginine depletion Asymptomatic Blood blood sample Blood samples characterization collected Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical critical patients Critically ill critically ill patients disease severity Gene regulation in immune cells genomic hallmark health emergency help heterogeneity Immunity Integrative analysis investigated metabolite metabolomic molecular neutrophil Neutrophils outbreak pathophysiology Patient patients Peripheral blood profile profiles proteomic public health threat reported selected Symptom Systems analysis T cell T cell dysfunction therapeutic strategy transcriptomic Tryptophan viral infection [DOI] 10.1038/s41467-021-24482-1 PMC 바로가기 [Article Type] Article
Gene Expression Meta-Analysis Reveals Interferon-Induced Genes Associated With SARS Infection in LungsImmunology Published on 2021-07-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] approach association clone coronavirus CoV Culture cultures CXCL10 defined distribution enrichment FIVE Gene Expression gene set enrichment analysis gene signature gene signatures Genes GSEA highlighting human lung identify IFIT3 include Infection infections lung MERS-CoV Meta-analysis mice Middle East mRNA expression nine OAS3 OASL over-expressed overcome positive predicted public health threat reported representing respiratory Result SARS infection SARS-CoV SARS-CoV infections SARS-CoV2 SARS-CoV2 infection Significant significant enrichment strain Strains therapeutic target virus XAF1 [DOI] 10.3389/fimmu.2021.694355 PMC 바로가기 [Article Type] Immunology
Severe acute respiratory syndrome coronavirus 2 reinfection in a coronavirus disease 2019 recovered young adult: a case report중증급성호흡기증후군 코로나바이러스 2 재감염 코로나바이러스 질병 2019 회복된 청년: 사례 보고Case Reports Published on 2021-07-162022-09-10 Journal: Journal of Medical Case Reports [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody back pain Case report Chain Reaction chills concerning constitutional symptoms coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 develop Fever Healthcare provider healthcare providers healthy immune response immune system Immunity Immunoglobulin immunoglobulins individual ineligible Infection lead management Misconceptions pathophysiology Patient plasma polymerase chain polymerase chain reaction positive positive patients public health threat question raise Reinfection reported Research resolved respiratory SARS CoV-2 serology serology test severe acute respiratory syndrome Coronavirus Side effect supported Symptom Symptoms tested the disease timeline timelines virus while widespread [DOI] 10.1186/s13256-021-02965-5 PMC 바로가기 [Article Type] Case Reports
Which National Factors Are Most Influential in the Spread of COVID-19?Article Published on 2021-07-162022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, 신종인플루엔자, [키워드] age Analysis caused conditions confirmed case country COVID-19 cumulative death death rate Diseases distributions environmental factors example expected extreme Factor global pandemic Growth Curve growth curve models H1N1 influenza Health help investigated Logistic median age MOST National Older outbreak pandemic parameter parameters predicted public health threat resource respiratory virus SARS-CoV-2 selected Spread spread of COVID-19 statistical analysis total population Travel Variation WHO [DOI] 10.3390/ijerph18147592 PMC 바로가기 [Article Type] Article