receptor-binding motif – Page 4 – Communicable Diseases Research

Structural insights into the cross-neutralization of SARS-CoV and SARS-CoV-2 by the human monoclonal antibody 47D11

Research Article

Published on 2021-06-022022-10-28
Journal: Science Advances [Category] COVID-19, SARS,

Possible inhibition of GM-CSF production by SARS-CoV-2 spike-based vaccines

SARS-CoV-2 스파이크 기반 백신에 의한 GM-CSF 생성 억제 가능성

Perspective

Published on 2021-05-222022-09-12
Journal: Molecular Medicine [Category] SARS, 진단,

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

Article

Published on 2021-05-132022-11-01
Journal: Cell Reports [Category] COVID-19, SARS,

[키워드] Abstract acute respiratory syndrome Analysis Antigen Antigen presentation antigen processing CD4 complex glycan coronavirus cross-protective dendritic cell dendritic cells dentritic cells Epitopes facilitate glycan glycopeptides glycoslyation glycosylated glycosylation highlight HLA class II HLA-DR HLA-II human leukocyte antigen identify immunogenicity data immunopeptidomics infected individual LC-MS leukocyte mapping observé peptide protective immune response Protein receptor binding motif receptor-binding motif recipient regions reported residue response responses Result reveal SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein spike the S protein the SARS-CoV-2 understanding unique Vaccine Vaccine design
[DOI] 10.1016/j.celrep.2021.109179 PMC 바로가기 [Article Type] Article

Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes

신규 결합 에피토프를 갖는 SARS-CoV-2 중화 항체의 구조적 기초

Research Article

Published on 2021-05-072022-08-13
Journal: PLoS Biology [Category] Biochemistry, SARS, 진단,

[키워드] ACE2 receptor acute respiratory syndrome coronavirus Ad5-hACE2 Ad5-hACE2 transduction mouse model angiotensin antibodies antibody antiviral efficiency applied binding binding epitope caused characterized coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 domain Economy epitope Epitopes global public health H2L2 platform H2L2 transgenic mice hACE2 help High-resolution X-ray crystallography structures human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human immunoglobulin human immunoglobulin variable regions humanized NAb identify immunize Immunoglobulin injection mAb mAb-related therapeutic intervention mAb-related therapeutic interventions monoclonal antibody mouse model NAbs Neutralizing activity Neutralizing antibodies neutralizing antibody novel non-blocking epitope pandemic platform PR1077 PR953 PR961 Prophylactic provide provided RBD RBM receptor-binding motif recombinant vaccines regions respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike protein Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein spike receptor-binding domain Structural analysis Structure subsequent tested the antibody the SARS-CoV-2 the spike protein therapeutic interventions therapy transgenic mice treatment groups variable regions X-ray crystallography
[DOI] 10.1371/journal.pbio.3001209 PMC 바로가기 [Article Type] Research Article

In silico investigation of critical binding pattern in SARS-CoV-2 spike protein with angiotensin-converting enzyme 2

Article

Published on 2021-03-252022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome angiotensin-converting enzyme 2 angiotensin-converting enzyme-2 beta-coronavirus bind binding binding affinity binding energy Biochemistry cellular cellular receptor complex Computational biology and bioinformatics Coronaviridae coronavirus coronavirus disease Coronavirus-2 COVID-19 Critical demonstrated drug expressed facilitate functional host cell host cell receptor in silico inhibit Interaction Lung epithelial cells management mechanism membranes Mutation occurred pandemic performed Protein–protein interaction receptor-binding motif responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein spike glycoprotein Spread the receptor-binding domain Treatment viral genome viral infection
[DOI] 10.1038/s41598-021-86380-2 PMC 바로가기 [Article Type] Article

Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Research

Published on 2021-03-112022-10-05
Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, 진단,

Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies

다클론성 인간 혈장 항체의 인식에 영향을 미치는 SARS-CoV-2 수용체 결합 도메인의 돌연변이에 대한 포괄적인 매핑

Article

Published on 2021-03-102022-09-11
Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단,

Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7

Research

Published on 2021-03-082022-10-05
Journal: Nature [Category] SARS, 변종,

Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

순환하는 SARS-CoV-2 스파이크 N439K 변이체는 항체 매개 면역을 피하면서 체력을 유지합니다

Article

Published on 2021-03-042022-09-11
Journal: Cell [Category] Fulltext, SARS, 변종, 진단,

[키워드] antibody Antibody therapeutics binding affinity Clinical outcome consequence COVID-19 disease drug Efficacy Emergency use epidemiological evade FDA fitness food hACE2 hACE2 receptor highlighting Immunity immunodominant increase Infection Lineage mAb mAbs maintain molecular monoclonal antibody escape mutate Mutation N439K neutralizing monoclonal antibodies neutralizing monoclonal antibody polyclonal polyclonal antibody polyclonal sera prevalent protein structure RBM receptor binding motif receptor-binding motif reduce reducing Replication response responses S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 spike spike Surveillance the SARS-CoV-2 Therapeutics US Food and Drug Administration Usage Vaccine variable region variant Viral viral fitness virulence virus viruses wild type wild-type
[DOI] 10.1016/j.cell.2021.01.037 PMC 바로가기 [Article Type] Article

A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2

고친화성 RBD 표적 나노바디는 SARS-CoV-2에 대한 융합 파트너의 효능을 향상시킵니다

Research Article

Published on 2021-03-032022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, SARS,

[키워드] ACE2 ACE2-RBD binding addition Affinity maturation antibodies antibody attachment bind binding affinity Characteristics competitive binding conserved Crystallographic studies Crystallographic study displaying distal domain Effect effective effective strategy epitope epitope distal Epitopes fusing fusion strategy generate high-affinity synthetic nanobody host cells host receptor hotspot identify immunological IMPROVE in vitro increase infect Infection interface kDa library screening llama-derived single-chain nanobodies nanobodies nanobody nanomolar affinity neutralization activity Neutralizing Neutralizing activity Neutralizing antibodies offer potency probe Protein provide pseudovirus RBD RBD binding RBD-targeting nanobodies RBD-targeting nanobody RBM RBM-antibodies RBM-binders Receptor-binding domain receptor-binding motif recognize recognizing Research S RBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pseudovirus simple simplicity single-chain antibody speed spike Spike protein spike receptor-binding domain SR31 structure-based design sybody target the receptor-binding domain the SARS-CoV-2 therapeutic tool protein toolkit two modestly neutralizing sybodies
[DOI] 10.1371/journal.ppat.1009328 PMC 바로가기 [Article Type] Research Article