Bi-ECDAQ: An electrochemical dual-immuno-biosensor accompanied by a customized bi-potentiostat for clinical detection of SARS-CoV-2 Nucleocapsid proteinsBi-ECDAQ: SARS-CoV-2 뉴클레오캡시드 단백질의 임상 검출을 위한 맞춤형 이중-전위기(bi-potentiostat)와 함께 제공되는 전기화학적 이중 면역 바이오센서Article Published on 2022-05-012022-09-11 Journal: Biosensors & bioelectronics [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] accompanied acquisition active site active sites All-in-one data acquisition platform approach Bi-potentiostat readout system carboxyl comparable complex COVID-19 COVID-19 patient Data acquisition diagnostics Diseases Dual working screen-printed electrode Electrochemical immunosensing eliminating flexible functional incompatible lack limit of detection matrix effect N-protein Nasopharyngeal swab nasopharyngeal swab sample nucleocapsid protein offered performed point-of-care Protein Recognition resulting SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 nucleocapsid protein Screen sensitive assay sensitivity significantly lower unmet need [DOI] 10.1016/j.bios.2022.114018 PMC 바로가기 [Article Type] Article
Recognition of Immune Cell Markers of COVID-19 Severity with Machine Learning Methods기계 학습 방법을 통한 COVID-19 심각도의 면역 세포 마커 인식Article Published on 2022-04-282022-09-11 Journal: BioMed Research International [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, 치료기술, [키워드] Algorithms analyzed B cell best Biomarker Biomarkers CD4 CD8 Cell cell type classifiers COVID-19 COVID-19 disease COVID-19 disease severity CX3CR1 Decision tree determine disease Disease progression disease severity feature filtered Gene expression analysis gene expression profile Host IL1B Immune cell immune cells immune response Immunological response immunological responses Inflammatory involved ITK KEGG pathway machine learning molecular mechanism molecular mechanisms monocyte Mortality NK cell Numerous PRDM1 random Random forest Recognition Regulation resulting SARS-COV-2 infection single-cell these cell These cells TLR2 [DOI] 10.1155/2022/6089242 PMC 바로가기 [Article Type] Article
In Silico Analysis Predicts a Limited Impact of SARS-CoV-2 Variants on CD8 T Cell Recognition실리코 분석은 CD8 T 세포 인식에 대한 SARS-CoV-2 변이체의 제한된 영향을 예측합니다Article Published on 2022-04-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Analysis antibody binding affinity bioinformatics bioinformatics & CD8 CD8 T cell CD8 T cell epitopes CD8 T cells Computational biology computational biology. Course COVID-19 pandemic Delta dominant variant epitope Epitopes HLA host immunity Immunity immunogenicity Impact infection with SARS-CoV-2 investigated Limited majority memory mutated Mutation new SARS-CoV-2 not altered pandemic predicted Protective raised Receptor binding Recognition reduced reported response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants selection pressure sequence similarity specific mutation specific mutations Spike protein T cell T cell epitopes T cells the spike protein vaccination Vaccine variant variants [DOI] 10.3389/fimmu.2022.891524 PMC 바로가기 [Article Type] Article
Seroreactivity of the Severe Acute Respiratory Syndrome Coronavirus 2 Recombinant S Protein, Receptor-Binding Domain, and Its Receptor-Binding Motif in COVID-19 Patients and Their Cross-Reactivity With Pre-COVID-19 Samples From Malaria-Endemic AreasCOVID-19 환자에서 중증 급성 호흡기 증후군 코로나바이러스 2 재조합 S 단백질, 수용체 결합 도메인 및 이의 수용체 결합 모티브의 혈청반응성과 말라리아 발병 지역의 코로나19 이전 샘플과의 교차 반응성Article Published on 2022-04-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 말라리아, 진단, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition age anti-S antibody antibody Antibody Response Antibody responses Antigen antigens Area Asthma blood sample Blood samples Community Comorbidities conducted coronavirus coronavirus 2 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 samples cross-reactive antibody cross-reactivity determine diabete diabetes disease Donor ELISA full-length Gender hospital IgG antibodies IgG antibody individual malaria malaria endemic-area participant Patient Plasmodium falciparum Plasmodium falciparum infection Pre-COVID-19 samples Protein RBD RBM Receptor-binding domain receptor-binding motif Recognition Recombinant S regions respiratory response responses S protein Sample SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 S SARS-CoV-2 S protein sera seroreactivity severe acute respiratory syndrome Coronavirus Study participants tested the receptor-binding domain the SARS-CoV-2 Treatment triggered weakened West while [DOI] 10.3389/fimmu.2022.856033 PMC 바로가기 [Article Type] Article
Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination eventsSARS-CoV-2 Omicron의 다양한 스파이크 유전자 돌연변이를 추적하여 여러 변이체 간 재조합 이벤트를 식별합니다.Article Published on 2022-04-262022-09-11 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Alpha Amino acid attribute change characteristic Co-infection Delta dominant epitope Epitopes Evolution of SARS-CoV-2 Frequency Genome identify in some include mechanism modifications monitoring MOST Mutation nine omicron other variant other variants pandemic of COVID-19 Pathogens phylogenetically Recognition recombinants Recombination recombination event Revertant SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes scanning South Africa spike gene Spike protein subsequent the spike protein Vaccine variant variants variants of interest viral pathogens VOCs VOIs [DOI] 10.1038/s41392-022-00992-2 PMC 바로가기 [Article Type] Article
Challenges of deep learning methods for COVID-19 detection using public datasetsResearch article Published on 2022-04-132022-10-05 Journal: Informatics in Medicine Unlocked [Category] 치료기술, [키워드] Accuracy aggregate automated binary classification challenge Characteristics Chest computed tomography and X-ray clinical settings Community Convolutional neural networks COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patient dataset deep Deep Learning Method disease distribution Ensemble classifier experiment Final highlighting hospital Hypothesis Improvements independent learning network outcome pathology Probability Recognition reported Research separate data source code training data [DOI] 10.1016/j.imu.2022.100945 [Article Type] Research article
How Do Point Mutations Enhancing the Basic Character of the RBDs of SARS-CoV-2 Variants Affect Their Transmissibility and Infectivity Capacities?SARS-CoV-2 변종 RBD의 기본 특성을 향상시키는 점 돌연변이가 전염성과 감염력에 어떤 영향을 미칩니까?Review Published on 2022-04-102022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor ACE2 receptors arginine arginine residue arginine residues basic binding affinity cell receptors character charged residues contribute coronavirus coulombic charges COVID-19 creating delta variant difference Effect electrostatic Enhancing glutamic acid host cells increase in Infectivity lysine Mu variant mutations Omicron variant Point Point mutation point mutations RBD RBD-ACE2 Recognition residue Salt Bridge SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spike protein RBD Spike proteins Spread spreading capacity surface electrostatic potential the RBD the SARS-CoV-2 the spike protein Transmissibility variants [DOI] 10.3390/v14040783 PMC 바로가기 [Article Type] Review
Evaluating telehealth lifestyle therapy versus telehealth psychotherapy for reducing depression in adults with COVID-19 related distress: the curbing anxiety and depression using lifestyle medicine (CALM) randomised non-inferiority trial protocolCOVID-19 관련 고통이 있는 성인의 우울증 감소를 위한 원격 의료 생활 방식 요법 대 원격 의료 심리 요법 평가: 생활 방식 의학(CALM) 무작위 비열등성 시험 프로토콜을 사용하여 불안 및 우울증 억제Article Published on 2022-03-272022-09-11 Journal: BMC Psychiatry [Category] 비임상, 임상, [키워드] adoption alcohol alleviate Anxiety approach baseline behavioural breath Care CBT clinical Clinical practice Clinical psychologist Cognitive behavioural therapy college conducted Data collection Depression depressive symptom Depressive symptoms determine diet Dietitian Digital video disorders drug Each elevated Eligible participants established therapy Evaluating Evidence exercise healthcare help hypothesised implementation individual individually randomised knowledge maintenance Mental Mental Disorders mental health Mental health disorder mental health disorders mental health services mental healthcare New non-inferiority trial nutrition occur offer participant partnership physical activity Physiologist platform population level Primary outcome protocol psychiatrist psychiatrists psychiatry Psychological distress psychologist psychotherapy Psychotherapy. randomised Recognition recruited reducing Region service Support telehealth therapy Treatment Victoria with COVID-19 [DOI] 10.1186/s12888-022-03840-3 PMC 바로가기 [Article Type] Article
Advanced Cognitive Algorithm for Biomedical Data Processing: COVID-19 Pattern Recognition as a Case StudyArticle Published on 2022-03-222022-11-16 Journal: Journal of Healthcare Engineering [Category] 치료기술, [키워드] Accuracy Algorithm ANN approved assist automated average chest X-ray cognitive Computerized tomography Coronavirus disease 2019 COVID-19 Critical CXR dataset decrease diagnosing Diagnosis disease effective growth identify individual introduced mortality rate Mutation outcome parameter pattern physician provide public health Recognition Research significant effect Spread Support SVM virus X-ray [DOI] 10.1155/2022/1773259 PMC 바로가기
SARS-CoV-2 host prediction based on virus-host genetic features바이러스 숙주 유전적 특징을 기반으로 한 SARS-CoV-2 숙주 예측Article Published on 2022-03-172022-09-11 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach bat bats Characteristics clinical manifestations codon Codons coronavirus different cell different cells Diseases dispersion feature Frequency Genetic genetic diversity Host host specificity hosts Human infect infecting Infection information involved molecular mechanism molecular mechanisms nucleotide nucleotide sequence Organisms pandemic Recognition relative SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic searched sequence sequences severe acute respiratory syndrome Coronavirus specificity suggested the SARS-CoV-2 Usage variable viral genome Viral transmission Wuhan Wuhan, China [DOI] 10.1038/s41598-022-08350-6 PMC 바로가기 [Article Type] Article