Mesenchymal Stem Cell-Based Therapy as an Alternative to the Treatment of Acute Respiratory Distress Syndrome: Current Evidence and Future PerspectivesReview Published on 2021-07-222022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] absence acute lung injury acute respiratory distress syndrome addition anti-apoptotic Anti-inflammatory anti-oxidative ARDS cell population clinical trial condition conditioned medium COVID-19 COVID-19 outbreak Culture current distress Donor effective Exosomes forms functional Future genetic manipulation growth heterogeneity histological incidence limitation Lung injury Mesenchymal stem cells morbidity and mortality MSC MSCs physiopathological mechanism Pneumonia proliferative regenerative respiratory Safe Secretome STEM stem cell Stress syndrome therapeutic therapeutic effect therapy Treatment [DOI] 10.3390/ijms22157850 PMC 바로가기 [Article Type] Review
The Role of Macrophages During Mammalian Tissue Remodeling and Regeneration Under Infectious and Non-Infectious ConditionsImmunology Published on 2021-07-142022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] cell death characterized condition conditions danger signal functional humans immune cells implicated IMPROVE Infection infectious conditions Injury lesion lung damage Lungs Macrophage response macrophages mammal mammals non-infected non-infectious non-infectious conditions organ organs Pathogenic microorganisms pathology patients recruitment regeneration regenerative remodeling repair respond responsible role SARS-CoV-2 scar Skeletal muscle therapy tissue tissue damage tissue repair Tuberculosis with COVID-19 [DOI] 10.3389/fimmu.2021.707856 PMC 바로가기 [Article Type] Immunology
Targeted Mitochondrial Therapy With Over-Expressed MAVS Protein From Mesenchymal Stem Cells: A New Therapeutic Approach for COVID-19Cell and Developmental Biology Published on 2021-06-112022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] ACE2 addition affecting approach cause Cell cellular cellular immunity COVID-19 damaged cell damaged tissue disease Diseases element expression expression of SARS-CoV-2 healthy host cell IFN immune immune response Impaired IMPROVE induce Inflammation innate immune response innate immune responses innate immune system interferon Ligand MAVS mesenchymal stem cell Mitochondria mitochondrial mitochondrial antiviral-signaling protein MSC MSCs New outer membrane pathogenesis of COVID-19 Probability Protein pulmonary involvement reduce regenerative regulate Regulatory rejection Replication S protein SARS-CoV-2 STEM stem cell Stress Symptom the SARS-CoV-2 these cell tissue inflammation transferring Transport viable treatment viral spike protein virus [DOI] 10.3389/fcell.2021.695362 PMC 바로가기 [Article Type] Cell and Developmental Biology
COVID-19 Impact on Musculoskeletal Regenerative Medicine Research: Maintaining Lab ContinuityArticle Published on 2021-06-052022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] activities activity Analysis assumed concerning continuity control measures COVID-19 COVID-19 diffusion COVID-19 emergency COVID-19 pandemic Effect eliminating greater handling hazard hierarchy Impact knowledge lab maintain maintaining measure Medicine mitigate Musculoskeletal operator Outbreaks pandemic physical Prevent regenerative regenerative medicine Research researcher Result risk Risk assessment risk of COVID-19 Safe SARS-CoV-2 social distancing therapeutic strategy tissue translation Ventilation work [DOI] 10.3390/ijerph18116110 PMC 바로가기 [Article Type] Article
Pulmonary stromal expansion and intra-alveolar coagulation are primary causes of COVID-19 deathResearch Article Published on 2021-05-242022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] aggregation airways Angiogenesis ARDS Autopsies Autopsy B-cells Bronchial epithelium cause causes CD163 cells Coagulation Complete composed consolidation COVID-19 death dominant Endothelium epithelial event Inflammatory response intra-alveolar lung lung parenchyma Macrophage MOST occurred pathology Patient pericyte pneumocyte produced proliferation pulmonary regenerative thrombocyte Thrombocytes Treatment virus [DOI] 10.1016/j.heliyon.2021.e07134 PMC 바로가기 [Article Type] Research Article
Stem cell therapies and benefaction of somatic cell nuclear transfer cloning in COVID-19 era코로나19 시대의 줄기세포 치료제와 체세포 핵이식 복제의 장점Review Published on 2021-05-122022-09-12 Journal: Stem Cell Research & Therapy [Category] SARS, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome Anti-inflammatory antivirals ARDS being benefit Bio-pharming boost caused Cell cell type Cell-based therapy cellular Clinical studies cloned COVID-19 COVID-19 patient COVID-19 patients damage dependence develop Drug testing Embryo embryonic embryos generate Genome reprogramming Health health emergency immunomodulatory effect immunomodulatory effects Interaction mesenchymal stem cell Mesenchymal stem cells MSC MSCs nuclear organ Organoid organoids potential benefit potential benefits prominence regenerative regenerative medicine Research respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SCNT somatic cell STEM stem cell stem cells structures syndrome therapeutic Therapies therapy transfer transgenic treat unique Vaccinations Vascular [DOI] 10.1186/s13287-021-02334-5 PMC 바로가기 [Article Type] Review
Liver histopathology in COVID-19 patients: A mono-Institutional series of liver biopsies and autopsy specimensCOVID-19 환자의 간 조직 병리학: 단일 기관 시리즈의 간 생검 및 부검 표본Article Published on 2021-05-012022-09-11 Journal: Pathology, research and practice [Category] SARS, 치료기술, [키워드] absence Activation adopted alteration analyzed Autopsies Autopsy biopsy changes Comorbidity COVID-19 COVID-19 patient COVID19 described ectasia Endothelial cell endothelial cells Hepatitis hepatocellular histopathological features histopathological finding Histopathology In situ hybridization infecting Kupffer cells liver Liver function test liver function tests Morphological morphological feature morphological features non-specific pathology protocols regenerative resulting SARS-CoV-2 SARS-COV-2 infection specimen steatosis therapeutic Therapies thrombosis Vascular viral infection viral particle [DOI] 10.1016/j.prp.2021.153451 PMC 바로가기 [Article Type] Article
MSC-derived exosomes carrying a cocktail of exogenous interfering RNAs an unprecedented therapy in era of COVID-19 outbreakReview Published on 2021-04-222022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] acute respiratory distress antiviral immune response candidate clinical status COVID-19 COVID-19 complication COVID-19 outbreak COVID-19 therapy ENhance Exosome Exosomes Gene therapy Immune suppression immunomodulatory involved lung management Mesenchymal stem cells miRNA MSCs pandemic Pathogenesis platform Prevent regenerative regimen RNA RNA interference SARS-CoV-2 SARS-CoV-2 pathogenesis siRNA syndrome target targets the SARS-CoV-2 therapeutic therapeutic option therapeutic strategy therapy Treatment viral spread Virus life cycle [DOI] 10.1186/s12967-021-02840-3 PMC 바로가기 [Article Type] Review
Transgene Delivery to Human Induced Pluripotent Stem Cells Using NanoparticlesReview Published on 2021-04-062022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 2019 coronavirus disease Affect approach biodegradability Cell COVID-19 COVID-19 vaccines Culture cytotoxicity delivery demonstrated diagnostics directional distal Efficiency example facilitate functional generate Genetic Human human induced pluripotent stem cells human induced pluripotent stem cells-derived cardiomyocytes immune responses in vivo induced lack Magnetic nanoparticles Modification nanomedicine nanoparticle Nanoparticles Nanotechnology offer pluripotent stem cell powerful tool Precision provided regenerative robust SARS-CoV-2 SARS-CoV-2 vaccine somatic cell STEM these cell transfection transgene Vaccine [DOI] 10.3390/ph14040334 PMC 바로가기 [Article Type] Review
Islet organoid as a promising model for diabetesReview Published on 2021-03-102022-10-29 Journal: Protein & Cell [Category] COVID-19, COVID19(2023년), SARS, [키워드] abnormality autologous cellular contributing to diabete diabetes disease Disease model Drug screening effort functional heterogeneity immature IMPROVE in vitro Infection involved islet islet organoid islet transplantation islets lack mechanism Morphological organ Organoid organoids pancreatic β cell pancreatic islet pathological conditions pluripotent/adult stem cell regenerative SARS-CoV-2 STEM therapy virus [DOI] 10.1007/s13238-021-00831-0 PMC 바로가기 [Article Type] Review