RNase
[용어속성] Term
Structural analysis of the active site architecture of the VapC toxin from
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation
Research Article
[키워드] accessory protein
activate
Activation
acute respiratory syndrome
antiviral activity
Betacoronavirus
calu-3 cells
cell death
characterized
cleave
contribute
coronavirus
Coronaviruses
CoV
Critical
cytoplasmic
dsRNA
enzyme
expressed
expression level
genes encoding
Genome
highly pathogenic
homolog
Host
host antiviral response
host innate immunity
IFN
IFN signaling
in vivo model
inactivation
Infection
Innate immunity
interferon
involved
Like
Lineage
mechanism
MERS
MERS-CoV
MERS-CoV infection
Middle East
murine
mutant
NLS
NS2
NS4b
nuclear localization signal
nucleus
offer
other coronaviruses
Pathogenesis
pathway
potential mechanism
Prevent
Protein
provide
Replication
reported
required
respiratory
respiratory syndrome coronavirus
RNA
RNase
SARS-CoV
single-stranded
Spread
ssRNA
subsequent
therapeutic intervention
translational
type I interferon
viral double-stranded RNA
viral pathogenesis
viral replication
virulence
[DOI] 10.1128/mBio.00258-16 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1128/mBio.00258-16 PMC 바로가기 [Article Type] Research Article
High-Resolution Transcriptome Maps Reveal Strain-Specific Regulatory Features of Multiple Campylobacter jejuni Isolates
고해상도 전사체 지도는 여러 Campylobacter jejuni 분리주의 균주 특이적 조절 기능을 보여줍니다
Research Article
[키워드] adaptation
addition
Analysis
analyzed
approach
Author
automated
Bacterial
bioinformatics
Campylobacter
Campylobacter jejuni
compared
consequence
conservation
conserved
contribute
CRISPR
different
DNA
ecological niche
ecological niches
eukaryote
eukaryotes
facilitate
feature
functional
gastroenteritis
Gene
Gene Expression
Gene regulation
Genetic
Genome
genome sequence
Genome sequences
genomic variation
genomic variations
genotypic
genotypic variations
growth
Host
hosts
humans
immune system
IMPROVE
include
integration
isolate
isolates
lead
Map
maturation
modulate
Multiple
organism
Organisms
Pathogens
pathway
phenotypic
phenotypic diversity
phenotypic variation
promoter
promoter regions
promoters
provide
Regulation
related
reveal
RNA
RNA sequencing
RNase
similarities
similarity
small RNA
SNP
sRNA
strain
Strains
stress conditions
time-consuming
transcribed
transcriptional
Transcriptome
transcriptomes
TSS
unique
upstream
Variation
whole-genome
[DOI] 10.1371/journal.pgen.1003495 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.pgen.1003495 PMC 바로가기 [Article Type] Research Article
Coronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence
Research Article
[키워드] absence
accelerated
accessory gene
acquisition
Activation
Analysis
Antiviral
antiviral response
Apoptosis
assay
association
Author
benefit
binding
caspase
catalytic
caused
Cell
cellular RNA
clinical disease
compared
conserved
coronavirus
CoV
cultures
Cytopathic effect
Defense
Degradation
Deleterious
demonstrated
eIF2α
ENCODE
eukaryotic translation
evade
Evolution
expression
Genome
growth
Host
host antiviral response
host cell
hydrophobic
immune response
indicated
Infected
infected cells
Infection
Innate
inoculation
Interaction
led to
mechanism
modify
modulation
molecular mechanism
motif
mutant
mutant virus
Newborn
observation
parental
pathology
Pathways
persistence
Phosphorylation
promoted
Protein
protein phosphatase 1
provided
pull-down
reducing
required
RNA degradation
RNA viruses
RNase
selective
sequence
subunit
suggested
survival
TGEV
tissue
translational
transmissible gastroenteritis virus
Viral RNA
virulence
virus
virus infection
[DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1002090 PMC 바로가기 [Article Type] Research Article
RNase L Mediated Protection from Virus Induced Demyelination
Research Article
[키워드] absence
Affect
alteration
ameliorated
Anti-viral
antiviral activity
antiviral molecules
Apoptosis
apoptotic cell
apoptotic cells
Author
Brain
Cell
Central nervous system
characterized
CNS
coronavirus
Coronavirus infection
Critical
deficiency
Degradation
Demyelination
dependent on
early
Encephalitis
Evidence
expression
foci
function
Host
IFN-α/β
immune
in viral
Increased
induced
induction of apoptosis
Infected
Infection
Infectious virus
infiltrating
inhibiting
Intervention
majority
manifested
mechanism
Mediated
mice
microglia
mitigate
morbidity
morbidity and mortality
mouse hepatitis virus
neurodegeneration
neuronal infection
neurotropic
not affect
pathology
pathway
phenotype
prevented
proinflammatory
PROTECT
protection
protective role
recent
reduce
reflected
RL
RNA
RNA degradation
RNase
severity
Spread
sustained
tissue
tissue damage
translation
type I interferon
unique
variant
viral control
viral replication
viral spread
viral tropism
virus
without affecting
[DOI] 10.1371/journal.ppat.1000602 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1000602 PMC 바로가기 [Article Type] Research Article