Immunodominant and Neutralizing Linear B-Cell Epitopes Spanning the Spike and Membrane Proteins of Porcine Epidemic Diarrhea VirusImmunology Published on 2022-01-192022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] amino acid sequence B-cell epitope cause Complete consensus sequence contribute demonstrated disease ELISA testing epidemic diarrhea epitope Epitope prediction genetic diversity greater group high mortality rate identify immune stimulation immunodominant epitope immunoinformatics insight linear linear B-cell epitope M protein membrane membrane protein NCBI database neutralization Neutralizing neutralizing epitope nine offer PEDV peptide peptide-based immunoassays Porcine epidemic diarrhea virus predicted profile Protein Proteins provided retrieved S2 subunit sera Seven Spike protein strain Strains the S protein the Spike Vaccine virus Virus neutralization [DOI] 10.3389/fimmu.2021.785293 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection감염성이 감소하고 BNT162B2 백신에 대한 감도가 다양한 SARS-COV-2 변이체가 감염 과정에서 개발됩니다.Clinical Trial Published on 2022-01-122022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, 변종, 임상, 치료기술, 치료법, [키워드] addition Affect Analysis analyzed Anti-spike Antibody neutralization antibody neutralization activity Author BNT162b2 BNT162b2 vaccine circulating convalescent plasma Course COVID-19 vaccine COVID-19 vaccines demonstrated elicit employment Evolution Frequency highlight Host human host human population impair in-depth analysis increase in individual infected individual infected individuals Infection infectivity capacity intra-host SARS-CoV-2 variant intra-host SARS-CoV-2 variants Intra-host variant intra-host variants L1197I mutation landscape less low frequencies mRNA mRNA-based mutated mutated variant mutated variants N gene N genes natural infection neutralization Neutralizing antibodies nose-throat swab nose-throat swabs pandemic plasma plasma neutralization activity platform Point mutation potential circulating variants Protective Quasispecies quasispecy raised reduced respiratory Respiratory system S gene S2 subunit SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 intra-host variability SARS-CoV-2 intra-host variant SARS-CoV-2 intra-host variants SARS-CoV-2 mutagenesis SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing Sequencing database Sequencing databases single-genome sequencing Spike protein Spike proteins spike variant Spread swab sample swab samples the SARS-CoV-2 the spike protein vaccinated individuals vaccination rate variant variants variants of concern [DOI] 10.1371/journal.ppat.1010242 PMC 바로가기 [Article Type] Clinical Trial
Functional Analysis of Human and Feline Coronavirus Cross-Reactive Antibodies Directed Against the SARS-CoV-2 Fusion PeptideSARS-CoV-2 융합 펩티드에 대한 인간 및 고양이 코로나바이러스 교차 반응성 항체의 기능 분석Immunology Published on 2022-01-052022-09-11 Journal: Frontiers in Immunology [Category] 변종, 진단, [키워드] Against Alpha alpha- Analysis antibody Antigen being betacoronaviruses binding broadly neutralizing antibodies conserved coronavirus Coronavirus infection Coronaviruses COVID-19 patients cross-reactive antibody demonstrated disease elicited endemic human coronaviruses epitope exhibited Fc-mediated effector function Fc-mediated effector functions fusion fusion peptide Human human sera immunogenic Infection Kinetics N-terminal Neutralizing activity pepscan peptide Protective S2 subunit SARS-CoV-2 SARS-CoV-2 variants sera severity spike the SARS-CoV-2 therapeutic Viral viral spike [DOI] 10.3389/fimmu.2021.790415 PMC 바로가기 [Article Type] Immunology
Emergence of a novel SARS-CoV-2 Pango lineage B.1.1.526 in West Bengal, India인도 서벵골에서 새로운 SARS-CoV-2 Pango 계보 B.1.1.526의 출현Article Published on 2022-01-012022-09-11 Journal: Journal of infection and public health [Category] SARS, 변종, [키워드] Analysis B.1.1.526 Characteristics characterized circulating clade Cluster collected country COVID-19 D614G distribution domain E484K E484K mutation E484K mutations emergence Epidemiology Evolution favor genomic geographical distribution GISAID database higher infectivity immune India Interaction Invasion Kolkata Lineage MONITOR Mutation mutations P681H pandemic Phylogenetic analysis Phylogenetic tree reported resulting retrieved S glycoprotein S2 subunit SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 sequences SARS-CoV-2 strain SARS-CoV-2 strains second wave sequence Sequence alignment Seven strain Strains Surveillance Temporal Temporal analysis transmembrane domain Transmissibility USA V1230L variant variant of SARS-CoV-2 variants viral envelope virion virus was performed West West Bengal. [DOI] 10.1016/j.jiph.2021.11.020 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation423 Published on 2021-12-202022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antiviral target arginine Beta binding caused cell line cellular cleavage cleavage site complement coronavirus coronavirus strains COVID-19 pandemic delta variant functional consequence highlight Host host cell host receptor human ACE2 Infection inhibiting initial mechanism membrane fusion mice molecular molecular mechanism Outbreaks pandemic Prevent primary cell Protein proteolytic proteolytic activation Proteolytic processing Receptor binding Research residue responsible S2 subunit S2′ S2′ cleavage S2′ site SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike variants Significance Spike protein subsequent syncytia formation target cells understanding variety viral entry viral infection viral spike [DOI] 10.1073/pnas.2111199119 PMC 바로가기 [Article Type] 423
Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escapeSARS-CoV-2를 표적으로 하고 탈출에 저항하는 나노바디의 높은 시너지 조합Research Article Published on 2021-12-152022-09-10 Journal: eLife [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibody binding site Combination conserved effective epitope functional Human identify Infection inhibit SARS-CoV-2 mechanism mechanisms N-terminal domain nanobodies nanobody neutralization Prophylactic Receptor binding domain S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants single-domain antibodies spike glycoprotein subunit synergistic synergy therapeutic therapeutic antibodies Vaccine variants of concern Viral viral escape viral neutralization [DOI] 10.7554/eLife.73027 PMC 바로가기 [Article Type] Research Article
Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells423 Published on 2021-12-062022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] A549 ACE2 ACE2 receptors acute respiratory syndrome airways angiotensin-converting enzyme 2 APEX2 bind bypasse C-terminal domain Calu-3 calu-3 cells cathepsin B Cell cells cofactor contribute coronavirus coronavirus disease COVID-19 demonstrated ENhance experiment expression facilitate glycoprotein H1299 Host host cell host receptor human lung cells human tissues Infection inhibitor interact Intervention lung membrane membrane fusion MYH9 N-terminal domain overexpression pan-coronavirus pathway promote protease pseudovirus infection reduce reduced S1-NTD S2 subunit SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 S serine 2 Significance significantly subunit suggested target the SARS-CoV-2 TMPRSS2 transmembrane variety viral entry virus virus entry wild type [DOI] 10.1073/pnas.2111011118 PMC 바로가기 [Article Type] 423
Pre-Existing Cross-Reactive Antibody Responses Do Not Significantly Impact Inactivated COVID-19 Vaccine-Induced Neutralization기존 교차 반응성 항체 반응은 비활성화된 COVID-19 백신 유도 중화에 큰 영향을 미치지 않습니다Immunology Published on 2021-11-192022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome analyzed antibody Antibody Response collected conserved CoV COVID-19 COVID-19 vaccine cross-reactive antibody cross-reactive antibody immunity distribution dose epitope Evidence fluorescence intensity greater healthy volunteer Humoral immunity IgG and IgM Immunity immunization Impact inactivated Inactivated vaccine increase in intensity linear neutralization not differ participant peptide peptides pre-vaccination previous study produced Protective provide recent Region Research response responses responses against S2 subunit SARS-CoV-2 SARS-CoV-2 vaccine seasonal coronavirus sera significantly stimulate the S protein vaccinee whole-virion SARS-CoV-2 vaccine [DOI] 10.3389/fimmu.2021.772511 PMC 바로가기 [Article Type] Immunology
One dose of COVID-19 nanoparticle vaccine REVC-128 protects against SARS-CoV-2 challenge at two weeks post-immunizationCOVID-19 나노입자 백신 REVC-128의 1회 용량은 면역화 후 2주에 SARS-CoV-2 공격으로부터 보호합니다Research Article Published on 2021-10-312022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, 진단, [키워드] alleviation animals antibody-dependent enhancement (ADE) antigenic binding body weight caused COVID-19 COVID-19 vaccine cross-reactive antibody display dose ectodomain Evidence evidence of glycine golden hamster hamster hamsters immunization immunized indicate induce less mice nanoparticle nanoparticle vaccine Neutralizing one-dose regimen position PROTECT Protein RBD Receptor-binding domain resulting S2 subunit Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus serum Serum neutralizing antibody significantly higher single dose single-shot vaccine Spike protein subunit subunits suppressed the SARS-CoV-2 virus tissue damage titre trimeric spike Trimeric spike protein vaccination Vaccine vaccine candidate vaccine safety vaccine stability Vaccines variants Viral Viral load viral loads viral spread weight loss [DOI] 10.1080/22221751.2021.1994354 PMC 바로가기 [Article Type] Research Article
Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strainSARS-CoV-2 게놈에서 COVID-19 사망률 위험에 대한 게놈 차원의 연관성 분석은 브라질 균주의 P.1과 함께 국소화되는 SARS-CoV-2 스파이크 단백질의 돌연변이를 식별합니다Article Published on 2021-10-012022-09-11 Journal: Genetic epidemiology [Category] SARS, 변종, 치료기술, 치료제, [키워드] Affect Alter Amino acid analyses Analysis analyzed approach association Brazil can not center change coding sequences Containment Control COVID-19 mortality COVID-19 patient database databases defined disease control driven by ENhance Follow-up Frequency Genome-wide association studies Genome-wide association study genome-wide significance geographical regions GISAID GISAID database GWAS highly pathogenic host susceptibility identify improvement Improvements in viral information loci locus Logistic Logistic regression methodology Mortality Mutation occur p value p values P.1 pathogenic pathogenicity remained risk S2 subunit SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 spike protein sequence variation sequenced single-stranded Spike protein starting strain submitted symptom severity target host cells the SARS-CoV-2 the SARS-CoV-2 genome variant viral entry viral genome viral infectivity viral strain virus WGS whole-genome sequencing [DOI] 10.1002/gepi.22421 PMC 바로가기 [Article Type] Article