Persistence of Neutralizing Antibodies to SARS-CoV-2 in First Wave Infected Individuals at Ten Months Post-Infection: The UnIRSA Cohort Study감염 후 10 개월에 첫 파동 감염된 개체에서 SARS-COV-2에 대한 항체 중화 항체의 지속성 : UNIRSA 코호트 연구Brief Report Published on 2021-11-122022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] Anti-spike antibody binding domain Bio-Techne Cohort collected COVID-19 Critical elicited first positive First wave fraction geometric geometric mean humoral IgG antibody IgG titers immune response individual Infection Italy longitudinal longitudinal analysis Mild Mild disease Month natural infection neutralization titer Neutralizing activity neutralizing antibody neutralizing humoral response pandemic PCR test performed pseudotype public health R&D Systems RBD Re-infection SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity seroconverted seronegative Seropositivity serum sample subject subjects USA Vaccine development was tested Wave were infected [DOI] 10.3390/v13112270 PMC 바로가기 [Article Type] Brief Report
LB9. Longitudinal antibody dynamics in children infected with SARS-CoV-2 through 6 months post-infectionLate Breaker Abstracts Published on 2021-11-042022-10-29 Journal: Open Forum Infectious Diseases [Category] COVID-19, [키워드] Abbott acute respiratory syndrome antibody Antibody titer Architect AstraZeneca binding Blood blood sample CDC changes in children collected Community consultant convalescent sera coronavirus COVID-19 vaccine decrease detectable Diagnosis elicit enrolled evaluate examined figure Flagship GlaxoSmithKline had no Hospitalized Immunocompromised Immunosuppression include infected with SARS-CoV-2 Infection Jesse laboratory-confirmed SARS-CoV-2 infection longitudinal Meissa Moderna neutralization potency neutralization titer Neutralizing Neutralizing activity neutralizing titers nucleocapsid Outpatient participant Pfizer pharmaceutical Post-infection Protein provided recruited reduction Result Sanofi Pasteur SARS-CoV-2 SARS-CoV-2 immunity Seattle Children’s Hospital supported symptomatic and asymptomatic symptomatic disease undetectable Viral protein Volunteer were assessed with COVID-19 [DOI] 10.1093/ofid/ofab466.1640 PMC 바로가기 [Article Type] Late Breaker Abstracts
Neutralizing antibody responses following natural SARS-CoV-2 infection: Dynamics and correlation with commercial serologic tests자연적인 SARS-CoV-2 감염에 따른 중화 항체 반응: 상업적 혈청학적 검사와의 역학 및 상관관계Article Published on 2021-11-012022-09-11 Journal: Journal of Clinical Virology [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] allocation anti-SARS-CoV-2 Anti-spike Antibody Response Antibody titer Antibody titers assays booster doses correlation COVID-19 cross-reactivity demonstrated detect diagnostic domain Dynamics Efficacy Elecsy Elecsys ELISA Euroimmun evaluate evaluated except for facilitate Follow-up healthcare worker IgG immunoassay immunoassays long term MONITOR NAbs Neutralizing antibodies Neutralizing antibody response neutralizing capacity participant participated performed plaque reduction neutralization Post-vaccine Protein reference standard SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies sera serologic test serologic tests seronegative seroprevalence survey significant decrease Support the immunoassay total antibodies vaccination [DOI] 10.1016/j.jcv.2021.104988 PMC 바로가기 [Article Type] Article
A third vaccine dose substantially improves humoral and cellular SARS-CoV-2 immunity in renal transplant recipients with primary humoral nonresponse세 번째 백신 접종은 1차 체액성 무반응이 있는 신장 이식 수혜자의 체액성 및 세포성 SARS-CoV-2 면역을 실질적으로 향상시킵니다.Article Published on 2021-11-012022-09-12 Journal: Kidney international [Category] MERS, SARS, 진단, [키워드] cellular humoral IMPROVE recipient renal SARS-CoV-2 immunity vaccine dose [DOI] 10.1016/j.kint.2021.09.001 PMC 바로가기 [Article Type] Article
SARS-CoV-2 immunity and functional recovery of COVID-19 patients 1-year after infectionSARS-CoV-2 감염 1년 후 COVID-19 환자의 면역 및 기능 회복Clinical Trial Published on 2021-10-132022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 임상, 진단, 치료기술, 치료제, [키워드] 95% CI Adaptive immunity analyzed Anti-RBD IgG anti-receptor-binding domain antibody B.1.1.7 B.1.351 B.1.351 variant B.1.351 variants chemiluminescence chemiluminescence immunoassay Chest CT China consequence COVID-19 COVID-19 patient COVID-19-related symptoms detectable Diagnosis discharge estimate functional General population highlight immune immune protection Immunity implication Infection Infectious diseases life long-lasting neutralization non-severe patient Outcomes research participant Patient Predictive preventive measure preventive measures prospective cohort Pulmonary function Quality of life RBD Re-infection recovered COVID-19 patient reduced remained reported risk SARS-CoV-2 immunity SARS-COV-2 infection Seroprevalence Severe patient severe patients significantly Survivors symptomatic Total variant WT SARS-CoV-2 [DOI] 10.1038/s41392-021-00777-z PMC 바로가기 [Article Type] Clinical Trial
Immunological Response to COVID-19 Vaccination in Ovarian Cancer Patients Receiving PARP InhibitorsArticle Published on 2021-10-082022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] anti-SARS-CoV-2 antibody cancer patient co-morbidities Cohort COVID-19 COVID-19 vaccination demographics enrolled General population healthy volunteer Infection inhibitor NAbs ovarian cancer PARP PARP inhibitors Patient Precaution provide receiving reduce response SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 neutralizing antibody second dose significantly lower the patient therapy treated Treatment two groups vaccination [DOI] 10.3390/vaccines9101148 PMC 바로가기 [Article Type] Article
Long-Term SARS-CoV-2 Specific Immunity Is Affected by the Severity of Initial COVID-19 and Patient AgeArticle Published on 2021-10-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory syndrome affecting age caused Cohort convalescent coronavirus coronavirus disease COVID-19 COVID-19 severity demonstrated effective Factor humoral immune response Humoral immunity immune response Immunity immunosuppressed patient initial management membrane protein memory response pandemic Patient patients persistence Protein SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity severity Specific spike Spike protein T cell T cell responses virus virus-neutralizing antibodies was determined [DOI] 10.3390/jcm10194606 PMC 바로가기 [Article Type] Article
Increased lethality in influenza and SARS-CoV-2 coinfection is prevented by influenza immunity but not SARS-CoV-2 immunity인플루엔자 및 SARS-CoV-2 동시 감염의 치사율 증가는 인플루엔자 면역에 의해 예방되지만 SARS-CoV-2 면역은 예방되지 않습니다.Article Published on 2021-10-052022-09-12 Journal: Nature Communications [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibodies Coinfection Comorbidity Complete coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic elevated ENhance IAV Immunity increase Increased Infection Influenza influenza A influenza A virus influenza vaccination influenza viral Influenza virus K18-hACE2 mice lower mortality mice morbidity Mortality mouse model organs outcome pandemic Prevent prevented Probability PROTECT reducing risk SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection Seasonal influenza severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease Spread Support susceptibility the disease These data vaccination Viral host response viral loads virus [DOI] 10.1038/s41467-021-26113-1 PMC 바로가기 [Article Type] Article
Highly active engineered IgG3 antibodies against SARS-CoV-2SARS-CoV-2에 대한 고활성 조작된 IgG3 항체403 Published on 2021-10-012022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 변종, 진단, [키워드] addition antibodies antibody Antigen antigen binding antigen-binding site binding binding activity complex protein domain engineered IgG3 exhibited expressed expression fucose function glycosylation homogeneous human serum IgG subclasse IgG subclasses IgG1 IgG3 mAb mAbs monoclonal antibodies neutralization neutralization potency neutralize Nicotiana benthamiana plant plant-based expression planta plants protective effect SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection SARS-CoV-2 spike protein Spike protein subtype therapy Vaccine development variant Viral viral surface Virus neutralization xylose [DOI] 10.1073/pnas.2107249118 PMC 바로가기 [Article Type] 403
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunityResearch Article Published on 2021-10-012022-10-30 Journal: The Journal of Biological Chemistry [Category] COVID-19, SARS, [키워드] ACE2, angiotensin-converting enzyme II adverse effect antibody approach BCA, bicinchoninic acid BLI, bioluminescent imaging can be used Cationic lipid CDM, chemically defined media Cell cellular characterized COVID19 CTCS, clarified tissue culture supernatant CVS, concentrated vesicle suspension DOPE, dioleoyl phosphatidylethanolamine dose DOTAP, dioleoyl-3-trimethylammonium propane DTZ, diphenylterazine elicited encapsulation ER, endoplasmic reticulum EV, extracellular vesicle Evidence Exosome Exosomes Extracellular vesicles form functional had no human cell Humoral response HUVEC, human umbilical vein endothelial cell immunogenic induce injection Lipid nanoparticle lipofection LNP LNP, Lipid Nanoparticle long-lasting luciferase expression mice mRNA NTA, nanoparticle tracking analysis nucleocapsid ORF, open reading frame pfPBS, particle-free PBS previous study Protein repeated responses Safe SARS-CoV-2 immunity SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SEC, size-exclusion chromatography Skeletal muscle spike sustained T-cell tested the SARS-CoV-2 tissue Toxicity vitreous fluid [DOI] 10.1016/j.jbc.2021.101266 PMC 바로가기 [Article Type] Research Article