Early expansion of myeloid-derived suppressor cells inhibits SARS-CoV-2 specific T-cell response and may predict fatal COVID-19 outcomeArticle Published on 2020-10-272022-11-01 Journal: Cell Death & Disease [Category] COVID-19, MERS, SARS, [키워드] Admission association Cell correlated COVID-19 defined depth analysis described fatal COVID-19 Frequency IFN-γ IL-1β IL-6 IL-8 immunological mechanism increase in indicate Infection inhibit inhibited intensive care mechanisms non-survivor outcome Pathogenesis Patient performed plasma predict regression analysis required SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV2 infection Specific T-cell response survivor Survivors T-cell TGF-β the disease therapeutic options TNF-α viral infection virus elimination [DOI] 10.1038/s41419-020-03125-1 PMC 바로가기 [Article Type] Article
A whole blood test to measure SARS-CoV-2-specific response in COVID-19 patientsOriginal Article Published on 2020-10-102022-10-04 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단, [키워드] Abstract Activation Antigen approach characterized CMV COVID-19 COVID-19 patient diagnostic diagnostic test disease endothelial Enterotoxin evaluated expressed FGF fibroblast G-CSF GM-CSF granulocyte-colony stimulating factor growth factor IFN-γ IFN-γ IL-10 IL-12p70 IL-13 IL-15 IL-17A IL-1ra IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 Image immune response individual inflammatory protein interferon IP-10 Macrophage MCP-1 median MIP-1β monocyte chemoattractant protein-1 Multiplex analysis Necrosis objective parameters Patient PDGF peptide platelet-derived growth factor Protein RANTES regulated Result SARS-CoV-2 SARS-CoV-2 peptide SEB secreted Serology response significantly increased Specific response T cell T-cell T-cell based tests Th1 Th2 TNF-α Vaccine Vascular VEGF Whole blood with COVID-19 [DOI] 10.1016/j.cmi.2020.09.051 PMC 바로가기 [Article Type] Original Article
SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition Research Published on 2020-09-012022-10-05 Journal: Nature Immunology [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] common cold Coronaviruses convalescent convalescent individuals COVID-19 diagnostic Diversity dominant Evidence facilitate functional Heterologous HLA class I HLA-DR identify Immunity individual individuals measure Mild symptom multiple epitopes peptide SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 peptide SARS-CoV-2-specific peptide seronegative similarity T cell T cell epitope T cell response therapeutic Vaccines viral infections [DOI] 10.1038/s41590-020-00808-x [Article Type] Research
Identification of SARS-CoV-2 Vaccine Epitopes Predicted to Induce Long-Term Population-Scale ImmunityReport Published on 2020-06-082022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, [키워드] ACE2 receptor activate Adaptive immune response B cell epitopes binding can be used CD4 CD8 conserved coronavirus Coronaviruses COVID-19 DNA DNA vaccine domain Efficacy engage epitope expected furin cleavage site generate genomic region histocompatibility complex HLA identification Immunity immunogenicity implementation include majority membrane fusion MHC mRNA peptide predicted proteome Region reported RNA RNA vaccine robust SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 vaccine SARS2 subset tested the spike protein thought Vaccine Vaccines validation viral genome [DOI] 10.1016/j.xcrm.2020.100036 PMC 바로가기 [Article Type] Report
Human Leukocyte Antigen Susceptibility Map for Severe Acute Respiratory Syndrome Coronavirus 2Genetic Diversity and Evolution Published on 2020-04-172022-10-30 Journal: Journal of Virology [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Affect allele Antigen binding binding affinity cause caused conserved coronavirus coronavirus 2 coronavirus disease Course COVID-19 cross-protective cross-protective immunity distribution epidemiological explain feasible Genes Genetic variation Genotype help higher risk histocompatibility complex HLA HLA alleles HLA type HLA-A Human human coronaviruses identify immune response Immunity IMPROVE in silico analysis individual leukocyte Map MHC MHC class I Pairing pandemic peptide performed predicted reported respiratory responsible SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 proteome severity shown susceptibility the disease vaccination Vaccine Variability Variation viral disease virus with COVID-19 [DOI] 10.1128/JVI.00510-20 PMC 바로가기 [Article Type] Genetic Diversity and Evolution