Rapid, scalable assessment of SARS-CoV-2 cellular immunity by whole-blood PCR Research Published on 2022-06-132022-10-05 Journal: Nature biotechnology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] Activation Antigen-specific T cells antigens breakthrough infections Cell cellular immunity chemokine correlated CXCL10 expression functional helping IFN-γ Immunity magnitude Messenger RNA monocyte mRNA normalized PCR populations protective immune response quantification quantitative PCR Rapid revaccination risk RNA extraction SARS-CoV-2 SARS-CoV-2 viral secrete stimulate T cell T cell activation [DOI] 10.1038/s41587-022-01347-6 [Article Type] Research
Nanobody-based label-free photoelectrochemical immunoassay for highly sensitive detection of SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질의 고감도 검출을 위한 나노바디 기반 무표지 광전기화학 면역분석Article Published on 2022-06-082022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] antibody caused COVID-19 COVID-19 epidemic determine Donor electron donor immunoassay Interaction limit of detection linear nanobody Pathogens photoelectric Photoelectrochemical plasma platform Protein provide public health Resonance effect SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 viral specific biomarkers spike Spike protein steric hindrance [DOI] 10.1016/j.aca.2022.339904 PMC 바로가기 [Article Type] Article
Proper Selection of In Vitro Cell Model Affects the Characterization of the Neutralizing Antibody Response against SARS-CoV-2체외 세포 모델의 적절한 선택은 SARS-CoV-2에 대한 중화 항체 반응의 특성화에 영향을 미칩니다Article Published on 2022-06-072022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody Antibody Response BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine Calu Calu-3 cell line cell lines cellular characterization characterized choice collected correlation COVID-19 COVID-19 vaccine Cytopathic effect cytopathic effects demonstrated Entry mechanism entry mechanisms evaluated in vitro increasingly inhibitory activity lack mechanisms Model mRNA mRNA vaccine natural infection Neutralizing Neutralizing activity occur of BNT162b2 PCR pseudovirus pseudoviruses response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2 viral Selection sera Single Cell subject Surrogates TMPRSS2 vaccine-induced antibodies vaccine-induced antibody variants Vero Vero E6 Viral viral entry viral entry pathway virus particles VOCs [DOI] 10.3390/v14061232 PMC 바로가기 [Article Type] Article
Engineering viral genomics and nano-liposomes in microfluidic platforms for patient-specific analysis of SARS-CoV-2 variantsSARS-CoV-2 변이체의 환자별 분석을 위한 미세유체 플랫폼에서 바이러스 게놈 및 나노 리포솜 엔지니어링Review Published on 2022-06-062022-09-11 Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료제, [키워드] (Alpha) (Beta) accelerate ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 B.1.1.529 B.1.351 B.1.617.2 Beta binding Blood Cell culture Coagulation contributing to Conventional coronavirus COVID-19 COVID-19 pandemic Delta encapsulate Engineering ethical concern ethical concerns genomic sequence glycoprotein highlight host cell host cells Increasing Lambda Microfluidics mutations mutations, variants of concerns nano-liposomes Neutralizing antibodies neutralizing antibody New omicron optimization organ Organ on-a-chip organ-specific pathogenicity persistence platform predict primates Protein recent Reinfection resource respiratory rising SARS-CoV-2 SARS-CoV-2 Spike mutation SARS-CoV-2 spike mutations SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral severe acute respiratory syndrome Coronavirus spike spike glycoprotein spike mutations Spike protein Spread strength the Spike therapeutic target therapeutic targets Therapeutics Transmissibility two-dimensional unmet need vaccination Vaccine variant variants Viral viral genomics viral infection Viral variants [DOI] 10.7150/thno.72339 PMC 바로가기 [Article Type] Review
Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19COVID-19에 대한 비강내 예방으로서 광범위한 변이 활성을 갖는 계란 유래 항-SARS-CoV-2 면역글로불린 Y(IgY)Clinical Trial Published on 2022-06-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] 2019 novel coronavirus 2019-nCoV activity Administered Against Alpha anti-SARS-CoV-2 Antiviral approval approvals B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta binding capture chicken immunoglobulin clinical clinical trial clinical trial body Clinical use contagiousness Convalescent patients COVID-19 cross-reactivity Delta demonstrated develop Diseases distribution double-blind effective Emergency use authorization enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Evidence evidence of greater healthy human tissue human tissues IgY Immunity immunized Immunoglobulin immunoglobulin Y index Infectious diseases intranasal intranasally multiple dose multiple doses nasal drop nasal drops nasal mucosa neutralization titer no evidence of Novel coronavirus omicron Phase 1 phase 1 study Placebo placebo-controlled Prevalence Prophylaxis raised Randomized RATs RBD Receptor-binding domain reduce reduced risk Safe safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral sensitivity sera Spike protein the receptor-binding domain the SARS-CoV-2 Tolerability Transmission Trial Vaccine Vaccine hesitancy variants variants of concern variety Viral virus [DOI] 10.3389/fimmu.2022.899617 PMC 바로가기 [Article Type] Clinical Trial
Vaccines alone will not prevent COVID-19 outbreaks among migrant workers-the example of meat processing plants백신만으로는 이주노동자 사이의 코로나19 발병을 막을 수 없다(육가공공장의 예)Review Published on 2022-06-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, [키워드] approach clinics Community country COVID-19 COVID-19 outbreak COVID-19 pandemic COVID-19 transmission droplet employment equity Evidence example expelled Health health equity high risk highlight include increasingly Infection prevention mandatory Mandatory vaccination Meat processing plants migrant worker migrants omicron Outbreaks outcome outcomes overcome performed physically plant Population Prevent Prevention and control PROTECT quantity required respiratory rate respiratory rates risk SARS-CoV-2 variant SARS-CoV-2 viral sick Spread Support Universal vaccination Vaccine Vaccine hesitancy Vaccines Ventilation Viral transmission [DOI] 10.1016/j.cmi.2022.02.004 PMC 바로가기 [Article Type] Review
Vaccine-induced systemic and mucosal T cell immunity to SARS-CoV-2 viral variantsSARS-CoV-2 바이러스 변이체에 대한 백신 유도 전신 및 점막 T 세포 면역Article Published on 2022-05-172022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] absence antibodies B1.351 CD4 CD4 T cell CD4 T cells CD8 T cell CD8 T cells CLARITY conserved COVID-19 vaccine Critical detectable effective Effectiveness elicit epitope Epitopes evade homologous Hospitalization Immunity immunization implication Infection knowledge lack lung immunopathology Lung pathology memory memory T cell memory T cells mucosal neutralized Neutralizing antibodies presence of antibody presence or absence PROTECT Protective protective vaccines provided SARS-CoV-2 SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 viral T cell T cell responses T cells Vaccine variant Viral viral control virus virus-neutralizing antibodies [DOI] 10.1073/pnas.2118312119 PMC 바로가기 [Article Type] Article
Label-Free Detection of the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein at Physiologically Relevant Concentrations Using Surface-Enhanced Raman Spectroscopy표면 강화 라만 분광법을 사용하여 생리학적으로 관련된 농도에서 SARS-CoV-2 스파이크 당단백질의 수용체 결합 도메인의 무표지 검출Article Published on 2022-05-052022-09-11 Journal: Biosensors [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] AFM Analysis analyte Antigen approach Cavity characteristic Concentration conformational detection develop Factor film glycoprotein group Interaction magnitude media optical pathogen Protein Radiation raising Raman spectroscopy RBD Receptor-binding domain reduced required S glycoprotein SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 viral scattering sensitivity SERS silver Spectroscopy spike sulfhydryl Surface-enhanced Raman spectroscopy the RBD the receptor-binding domain the SARS-CoV-2 variant variants Viral antigen viral antigens Viral protein virus Volume [DOI] 10.3390/bios12050300 PMC 바로가기 [Article Type] Article
Inactivation and Recovery of High Quality RNA From Positive SARS-CoV-2 Rapid Antigen Tests Suitable for Whole Virus Genome Sequencing전체 바이러스 게놈 시퀀싱에 적합한 양성 SARS-CoV-2 신속 항원 테스트에서 고품질 RNA의 비활성화 및 회수Article Published on 2022-05-032022-09-11 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] aligned Antigen antigen testing applied B.1.1.7 can be used circulating variant circulating variants Community Concentration conserved coronavirus 2 demonstrated detect diagnostic diagnostic protocol diagnostic test diagnostic tests each time-point epidemiological Epidemiology Genome genomic sequence identify imperative inactivated Infection lateral flow Lateral flow device Lineage Lineage B.1.1.7 lysed lysis management Omicron variant outbreak positive positive result protocol public health qPCR Quality Rapid Rapid antigen diagnostic test replicating virus respiratory risk Risk management RNA RNA extraction RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 viral sequence Sequencing Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spread stability storage strain Suspension Template Test tested utility Variation viral nucleocapsid protein viral particle Viral particles Viral RNA virus virus genome was used were used whole virus genome sequencing. [DOI] 10.3389/fpubh.2022.863862 PMC 바로가기 [Article Type] Article
The Impact of Androgen Deprivation Therapy on COVID-19 Illness in Men With Prostate Cancer전립선암이 있는 남성의 COVID-19 질병에 대한 안드로겐 결핍 요법의 영향Multicenter Study Published on 2022-05-022022-09-11 Journal: JNCI Cancer Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% CI 95% confidence interval addition adjusted Affect Analysis androgen Androgen receptor androgens body mass body mass index Cell clinical disease cohorts Comorbidity COVID-19 COVID-19 diagnosis COVID-19 disease COVID-19 illness death defined demonstrated Deprivation epithelial cells evaluated Follow-up hazard ratio higher risk Hospitalization illness Impact Logistic lower risk mechanical ventilation median median age multicenter multicenter study multivariable Not demonstrated Older outcomes overall survival oxygen Oxygenation Patient patients performed Prostate cancer protease Regression model regulated respiratory epithelial cells retrospective cohort SARS-CoV-2 SARS-CoV-2 viral severe COVID-19 severe COVID-19 disease severe COVID-19 illness significantly statistical test statistically suggested supplemental oxygen survival therapy TMPRSS2 Treatment upregulated within 6 months [DOI] 10.1093/jncics/pkac035 PMC 바로가기 [Article Type] Multicenter Study