Light acupuncture and five-element music therapy for nurses’ mental health and well-being during and post-COVID-19: protocol for a randomised cross-over feasibility study코로나19 기간 및 이후 간호사의 정신 건강과 웰빙을 위한 가벼운 침술 및 5요소 음악 요법: 무작위 교차 타당성 연구를 위한 프로토콜Article Published on 2022-04-292022-09-11 Journal: BMJ Open [Category] 임상, [키워드] affected Analysis Anxiety asked assessments Blinding clinical clinical trial Combination Community Complete COVID-19 pandemic cross-over Depression depression & dissemination Edith eligible engage Ethical approval Ethics ethics committee evaluate Evidence feasibility Feasibility study form Health healthcare professionals hospital Human Impact IMPROVE include Intention International Intervention Laser Laser therapy LIGHT Local management mental health mood disorders music therapy National New Nurse online questionnaire online questionnaires PAIN MANAGEMENT participant peer-reviewed performed Primary outcome profession protocol Quality of life randomised recruited registration number required Research Ethics research findings resulting secondary outcome Secondary outcomes Studio therapeutic effect therapy Treatment treatment group Trial Two-arm university Well-being [DOI] 10.1136/bmjopen-2021-057106 PMC 바로가기 [Article Type] Article
Comparative 6-Month Wild-Type and Delta-Variant Antibody Levels and Surrogate Neutralization for Adults Vaccinated with BNT162b2 versus mRNA-1273BNT162b2 대 mRNA-1273 백신 접종을 받은 성인의 6개월 야생형 및 델타 변이체 항체 수준 및 대리 중화 비교Observational Study Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, [키워드] ACE-2 age angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody concentrations Antibody Response binding blood sample BNT162b2 BNT162b2 vaccine Comparative comparison Concentration COVID-19 Delta delta variant demonstrated dose Effectiveness Efficacy FIVE Humoral immunity humoral immunogenicity IgG antibody individual less Level Lineage lineages Mann-Whitney U test mRNA mRNA vaccine mRNA vaccines mRNA-1273 mRNA-1273 vaccine mRNA-1273 vaccines outcome participant prospective observational cohort provided RBD Receptor binding domain Result SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines secondary outcome Secondary outcomes serological marker significantly higher spike spike IgG Spike protein Spike proteins surrogate tested type strain vaccine dose vaccinees Vaccines while wild-type wild-type strain [DOI] 10.1128/spectrum.02702-21 PMC 바로가기 [Article Type] Observational Study
Comparison of standard prophylactic, intermediate prophylactic and therapeutic anticoagulation in patients with severe COVID-19: protocol for the ANTICOVID multicentre, parallel-group, open-label, randomised controlled trial중증 COVID-19 환자에 대한 표준 예방, 중간 예방 및 치료 항응고 요법의 비교: ANTICOVID 다기관, 병렬 그룹, 공개 라벨, 무작위 대조 시험에 대한 프로토콜Article Published on 2022-04-262022-09-11 Journal: BMJ Open [Category] 임상, [키워드] absence all-cause mortality anticoagulation approved bleeding body mass body mass index Clinical improvement Clinical practice clinical scale Coagulopathy component Computed tomography COVID-19 criterion D-dimer D-dimer level D-dimer levels death defined dysfunction Efficacy and safety ethical committee Ethics ethics committee Evolution extension extreme followed by France French Hierarchical High-dose Hospital stay Ile include induce intensive care intensive care unit Invasive mechanical ventilation life low-dose lung major bleeding event Microvascular thrombosis multicentre Multiorgan Open-label outcome oxygen parallel-group Paris pathophysiological Patient patients patients with COVID-19 peer-reviewed primary endpoint Prophylactic protocol pulmonary artery Quality of life randomisation randomised randomised controlled randomised controlled trial randomised trials receive recruit registration number renal renal failure respiratory respiratory infections secondary Secondary outcomes Sepsis sepsis-induced coagulopathy severe COVID-19 stratified submitted the primary endpoint therapeutic anticoagulation Thromboembolism thrombosis thrombotic Trial trials Vasopressor venous ventilator weight [DOI] 10.1136/bmjopen-2021-059383 PMC 바로가기 [Article Type] Article
Online positive parenting programme for promoting parenting competencies and skills: randomised controlled trialRandomized Controlled Trial Published on 2022-04-192022-10-05 Journal: Scientific Reports [Category] 임상, [키워드] active control group baseline behavioural blinded both group children clinical competency Control COVID-19 pandemic effective Effectiveness emotional equation groups healthy IMPROVE Intervention intervention group investigated mitigate MOST offered parent parental positive Primary outcome problem randomised controlled trial recorded reduction reported Secondary outcomes Trial registration were measured [DOI] 10.1038/s41598-022-10193-0 PMC 바로가기 [Article Type] Randomized Controlled Trial
A multicenter, open-label, randomized, proof-of-concept phase II clinical trial to assess the efficacy and safety of icatibant in patients infected with SARS-CoV-2 (COVID-19) and admitted to hospital units without invasive mechanical ventilation: study protocol (ICAT-COVID)SARS-CoV-2(COVID-19)에 감염되어 침습적 기계 환기 없이 병원에 입원한 환자에서 이카티반트의 효능과 안전성을 평가하기 위한 다기관, 공개 라벨, 무작위, 개념 증명 II상 임상 시험: 연구 프로토콜(ICAT-COVID)Article Published on 2022-04-122022-09-11 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 ACE2 acute respiratory distress acute respiratory distress syndrome Antigen ARDS attacks bradykinin caused Clinical efficacy clinical status clinical trial ClinicalTrials Comorbidity control group COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia Cytokine storm death Diagnosis discharge discharged doses effective Effectiveness Efficacy Efficacy and safety eligible Endothelial cell endothelial cells EudraCT Evidence evidence of expected experimental group global pandemic Healthcare system Healthcare systems hospital Hospitalized Icatibant include infected with SARS-CoV-2 Inflammatory response inhibiting invasive mechanical Invasive mechanical ventilation Mortality multicenter Open-label outcome Patient patients hospitalized Pneumonia Primary outcomes protease pulmonary infiltrates Radiographic randomization Randomized receive receptor receptor antagonist respiratory distress Respiratory distress syndrome RT-PCR Safe Sample size SARS SARS-CoV-2 secondary Secondary outcomes Spain Standard of care Study protocol subcutaneously Symptoms syndrome the SARS-CoV-2 the WHO thought treat Treatment viral infection with COVID-19 working hypothesis [DOI] 10.1186/s13063-022-06219-7 PMC 바로가기 [Article Type] Article
Immunogenicity of COVID-19 vaccines in patients with hematologic malignancies: a systematic review and meta-analysis혈액암 환자에서 코로나19 백신의 면역원성: 체계적 고찰 및 메타분석Meta-Analysis Published on 2022-04-122022-09-12 Journal: Blood advances [Category] COVID19(2023년), SARS, 진단, [키워드] active treatment adverse event Analysis approach cellular response Cellular responses clinical study Cochrane Central conducted Confidence intervals COVID-19 infection COVID-19 vaccination COVID-19 vaccine disease dose doses expressed first dose healthy control hematologic highest immune response immunogenicity leukemia lowest malignancies malignancy Meta-analysis monoclonal antibody morbidity and mortality Neutralizing antibodies Neutralizing antibody response New Odds ratio outcome Patient patient group positive random effect Rate reduce required respond poorly second dose Secondary outcomes single-arm study stratified systematic review therapy Treatment [DOI] 10.1182/bloodadvances.2021006333 PMC 바로가기 [Article Type] Meta-Analysis
Clinical efficacy and safety of high-flow nasal cannula (HFNC) in acute hypoxaemic patients with COVID-19: a protocol for a systematic review and meta-analysisCOVID-19를 가진 급성 저산소병 환자에서 고유 유량 코 캐뉼라 (HFNC)의 임상 효능 및 안전성 : 체계적인 검토 및 메타 분석을위한 프로토콜Article Published on 2022-04-122022-08-31 Journal: BMJ Open [Category] meta-analysis, [키워드] Acute respiratory failure adult intensive & age and sex approach Caregivers clinical Clinical efficacy Cochrane Library Continuous data COVID-19 COVID-19 patient COVID-19 patients Critical Critical care data extraction determine develop disease severity Efficacy and safety eligibility criteria Ethical approval Ethics evaluate for inclusion HFNC High-flow nasal cannula hypoxaemic respiratory failure identify increased risk Infection transmission infections Intensive intensive care intensive care unit intubation mean difference meta-analyses Meta-analysis Mortality nasal nasal cannula outcome Participants Patient peer-reviewed performed Primary outcome PROSPERO protocol randomised controlled trial RCT RCTs registration number required respiratory Respiratory failure respiratory infections risk risk of bia risk ratio secondary outcome Secondary outcomes Subgroup analyses subgroup analysis systematic review the mean Treatment undergo Web of Science [DOI] 10.1136/bmjopen-2021-057743 PMC 바로가기 [Article Type] Article
Neuromodulation through brain stimulation-assisted cognitive training in patients with post-COVID-19 cognitive impairment (Neuromod-COV): study protocol for a PROBE phase IIb trial코로나19 이후 인지 장애 환자의 뇌 자극 보조 인지 훈련을 통한 신경 조절(Neuromod-COV): PROBE 2b상 시험을 위한 연구 프로토콜Article Published on 2022-04-112022-09-11 Journal: BMJ Open [Category] 임상, [키워드] among others anodal approach behavioural Brain clinical trials cognitive Cognitive impairment cognitive impairments cognitive performance cognitive training Combination COVID-19 defined develop diagnosed with COVID-19 Direct Current disease severity double-blinded Effect Effects Ethical approval Ethics ethics committee Evidence follow-up assessment follow-up assessments Greifswald IIb include International Intervention life measure Medicine memory mental health muscle relaxation National NEUROLOGY neuromodulation Open-label outcome Patient peer-reviewed postintervention Primary outcome Quality of life randomised receive registration number Relaxation training Result secondary Secondary outcomes Study protocol Symptom Symptoms Therapeutic approach these symptoms Trial university Working memory [DOI] 10.1136/bmjopen-2021-055038 PMC 바로가기 [Article Type] Article
Gatekeeper training for vendors to reduce pesticide self-poisoning in rural South Asia: a study protocol for a stepped-wedge cluster randomised controlled trial남아시아 농촌 지역에서 살충제 중독을 줄이기 위한 공급업체를 위한 게이트키퍼 교육: 계단식 쐐기형 클러스터 무작위 통제 시험을 위한 연구 프로토콜Article Published on 2022-04-042022-09-11 Journal: BMJ Open [Category] Coronavirus, 임상, [키워드] 24 hours alcohol approved Asia Attempted suicide Cluster Committee conducted COVID-19 division divisions Edinburgh Effectiveness Ethics ethics committee evaluate faculty Faculty of Medicine form high risk hospital identify individual Intervention introduced kill Other outcome outcome measure outcome measures peer-reviewed pesticide pesticides poisoning Prevent Primary outcome public health random randomised controlled trial Randomised trial reduce registration number Research Ethics restriction Result review secondary Secondary outcomes self-harm South Study protocol Suicide suicide & Surveillance toxicology university [DOI] 10.1136/bmjopen-2021-054061 PMC 바로가기 [Article Type] Article
The use of standardized Brazilian green propolis extract (EPP-AF) as an adjunct treatment for hospitalized COVID-19 patients (BeeCovid2): a structured summary of a study protocol for a randomized controlled trial입원한 COVID-19 환자(BeeCovid2)의 보조 치료제로 표준화된 브라질 녹색 프로폴리스 추출물(EPP-AF)의 사용: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Article Published on 2022-04-042022-09-11 Journal: Trials [Category] 임상, [키워드] 1:1 2019 coronavirus disease ACE2 acute COVID-19 Acute kidney injury adjunct Administered adults hospitalized Affect affected age anti-inflammatory agents association Bacterial balloon pump Brazil Cancer patients chronic disease Chronic diseases Chronic kidney disease clinical study conducted coronavirus disease COVID-19 demonstrated diagnosis of COVID-19 double-blinded ECMO Effectiveness Evidence experimental evidence extracorporeal membrane oxygenation Fungal infection groups heart failure HIV patients Hospital stay hospitalized COVID-19 patient hospitalized patients immunoregulation Immunosuppression impacts impossibility include Infection intra-aortic balloon pump Kidney disease Liver disease mechanical ventilation medication moderate moderate to severe outcome PAK1 PAK1 blocker pandemic Patient patients hospitalized Placebo placebo-controlled clinical study pregnant women Primary outcome Propolis protocol randomization Randomized Randomized controlled trial receive reducing renal replacement therapy replacement therapy secondary Secondary infection Secondary outcomes severe liver disease Spread standard care Study protocol Symptom targets TMPRSS2 Treatment Trial vasoactive drugs with COVID-19 [DOI] 10.1186/s13063-022-06176-1 PMC 바로가기 [Article Type] Article