Combined use of a broad-panel respiratory multiplex PCR and procalcitonin to reduce duration of antibiotics exposure in patients with severe community-acquired pneumonia (MULTI-CAP): a multicentre, parallel-group, open-label, individual randomised trial conducted in French intensive care units중증 지역사회획득폐렴(MULTI-CAP) 환자의 항생제 노출 기간을 줄이기 위해 광범위 호흡 다중 PCR과 프로칼시토닌을 함께 사용: 프랑스어 집중적으로 수행된 다기관, 병렬 그룹, 공개 라벨, 개별 무작위 시험 케어 유닛Randomized Controlled Trial Published on 2021-08-182022-09-12 Journal: BMJ Open [Category] MERS, 임상, 진단, [키워드] 1:1 adult intensive & adult thoracic medicine Algorithm antibiotic Antibiotics approach approved Bacterial Biomarker clinical clinical criteria clinician Combined combined use Committee community-acquired pneumonia conducted control arm Critical Critical care days alive Declaration of Helsinki Diagnosis diagnostic Diagnostic microbiology drug Ethics excluded French Hypothesis Intensive intensive care intensive care unit intervention arm molecular molecular diagnostics molecular test multicentre Multiplex PCR Open-label parallel-group parenchymal Patient peer-reviewed performed Person Pneumonia primary endpoint procalcitonin protection public health randomisation randomised Randomised trial reduce reducing Registered respiratory infections Safety selection pressure Spread submitted the patient Thoracic Treatment Trial usual care written Informed Consent [DOI] 10.1136/bmjopen-2020-048187 PMC 바로가기 [Article Type] Randomized Controlled Trial
The Algerian Chapter of SARS-CoV-2 Pandemic: An Evolutionary, Genetic, and Epidemiological ProspectSARS-COV-2 전염병의 알제리 장 : 진화론 적, 유전 적, 역학 전망Article Published on 2021-08-022022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] addition Algeria amino-acid Analysis ancestor characteristic common connection country dataset Deleterious disease dissemination Evolution examined Genome Genomic analysis Haplotype haplotype network analysis International Local measure Missing data MOST Mutation mutations Nsp3 orf3a gene outbreak pandemic Phylogenetic Phylogeny phylogeography pilgrimage Proteins recent SARS-CoV-2 SARS-CoV-2 pandemic Saudi Arabia selection pressure sequence sequences statistical analyses the disease the SARS-CoV-2 time TMRCA toolkit Transmission transmission route Travel unique USA while [DOI] 10.3390/v13081525 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine DevelopmentMolecular Biosciences Published on 2021-07-282022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acute respiratory syndrome affecting alleviate antibody antigenic target antiviral therapeutics approach can be used cell lines clinical development conserved Coronaviral coronavirus coronavirus disease Coronavirus pandemic Coronavirus-2 COVID COVID-19 COVID-19 pandemic cross-react demonstrated detect development Diagnosis diagnosis of COVID-19 diagnostic diagnostics domain effective ELISA extrapolation facilitate host cell receptor Human IgM and IgG in vitro study Infection inhibiting interact Lateral flow immunoassays mAb mAbs molecular monoclonal antibody Mortality N-terminal domain neutralize Neutralizing neutralizing antibody pandemic platform polyclonal antibody Prevent Prophylaxis RBD Receptor binding domain Region researcher S-protein S1 and S2 S1 domain S2 domain SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection selection pressure sequence similarity Serological assay spike spike gene spike glycoprotein the RBD Treatment trimer Vaccine Vaccines Viral protein virus virus-cell membrane fusion [DOI] 10.3389/fmolb.2021.607886 PMC 바로가기 [Article Type] Molecular Biosciences
Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library사전 구조화된 DNA 라이브러리의 야생형 및 B.1.1.7 SARS-CoV-2 스파이크 단백질에 대한 다양한 고친화성 DNA 앱타머AcademicSubjects/SCI00010 Published on 2021-07-212022-09-10 Journal: Nucleic Acids Research [Category] SARS, 변종, 진단, 치료기술, [키워드] adopted affinity B.1.1.7 B.1.1.7 variant binding comparable COVID-19 diagnostic DNA DNA library DNA sequences enrichment exhibited experiment hairpin structure heat human saliva identify in vitro lentivirus limit of detection motif performed pool pseudotyped random S1 protein S1 subunit Saliva SARS-CoV-2 SARS-CoV-2 spike protein secondary secondary structure selection experiment selection pressure sequence Spike protein the S1 protein the S1 subunit the SARS-CoV-2 Trimeric spike protein were assessed wild-type wildtype [DOI] 10.1093/nar/gkab574 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010
Evolutionary Tracking of SARS-CoV-2 Genetic Variants Highlights an Intricate Balance of Stabilizing and Destabilizing MutationsSARS-CoV-2 유전자 변이체의 진화 추적은 안정화 돌연변이와 불안정화 돌연변이의 복잡한 균형을 강조합니다Research Article Published on 2021-07-202022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] A222V accounted addition analyzed B.1 balance catch caused COVID-19 pandemic D614G data set data sets database death Evolution Genome Genome sequences genomic information globe Infection mechanism Mutation mutations persistence Phylogenetic analysis Protein protein structures Q57H recorded S477N SARS-CoV-2 SARS-CoV-2 evolution selection pressure sequence stability structures T85I Therapeutics Vaccine variant variants Variation Viral viral mutation Viral mutations Viral protein Viral proteins [DOI] 10.1128/mBio.01188-21 PMC 바로가기 [Article Type] Research Article
Vaccine escape in a heterogeneous population: insights for SARS-CoV-2 from a simple modelScience, Society and Policy Published on 2021-07-142022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] clinical trial concerning Contact COVID-19 demonstrated develop disease effective effective vaccine Effectiveness epidemiological group heterogeneous heterogeneous population highest Infection mathematical modify mutate Mutation occur pandemic Policy Prevalence reduce reducing risk SARS-CoV-2 selection pressure subsequent the SARS-CoV-2 the SARS-CoV-2 virus vaccination Vaccine vaccine escape vaccine-induced immune response Vaccines variants widespread [DOI] 10.1098/rsos.210530 PMC 바로가기 [Article Type] Science, Society and Policy
Genome-Wide Analysis of Codon Usage Patterns of SARS-CoV-2 Virus Reveals Global Heterogeneity of COVID-19SARS-COV-2 바이러스의 코돈 사용 패턴의 게놈 전체 분석은 COVID-19의 글로벌 이질성을 보여줍니다.Article Published on 2021-06-182022-09-10 Journal: Biomolecules [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 can not causative agents characterized codon codon usage Codon usage bias comprehensive analysis coronavirus coronavirus disease coronavirus disease COVID-19 COVID-19 error genome organization geographic location global genome global genomes globe heterogeneity heterogeneity of COVID-19 Host host adaptation implicated lack margin margin of error Mutation Mutational bias natural selection outbreak pattern performed reduce Research respiratory Sample size SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 viral selection pressure severe acute respiratory syndrome Coronavirus significantly Standard deviation strain Strains Support Taking the SARS-CoV-2 the SARS-CoV-2 genome Usage Viral viral genome viral lineage viral strains virus virus genome whole genome [DOI] 10.3390/biom11060912 PMC 바로가기 [Article Type] Article
Antibiotic resistance during and beyond COVID-19Supplement Papers Published on 2021-06-152022-10-29 Journal: JAC-Antimicrobial Resistance [Category] COVID-19, [키워드] Antibiotic resistance antibiotic use Antibiotics Bacteria Clearing Community coronavirus COVID-19 COVID-19 pandemic declined died events healthcare hospital ICU implication Infection information management measure New Non-COVID-19 non-COVID-19 patient normality Nosocomial infections OC43 pandemic Population reduced reducing Restricted selection pressure social distancing social interaction suffered the vaccine Transmission Travel Treatment Vaccine Vaccine failure virus [DOI] 10.1093/jacamr/dlab052 PMC 바로가기 [Article Type] Supplement Papers
V367F Mutation in SARS-CoV-2 Spike RBD Emerging during the Early Transmission Phase Enhances Viral Infectivity through Increased Human ACE2 Receptor Binding Affinity초기 전파 단계에서 나타나는 SARS-CoV-2 스파이크 RBD의 V367F 돌연변이는 증가된 인간 ACE2 수용체 결합 친화도를 통해 바이러스 감염성을 향상시킵니다Virus-Cell Interactions Published on 2021-06-022022-09-10 Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Analysis analyzed angiotensin assays binding binding affinity caused circulating coronavirus CoV COVID-19 COVID-19 pandemic Critical domain dominant dominant mutations drug ELISA enzyme-linked immunosorbent enzyme-linked immunosorbent assay Genome genomes hot spot Human human ACE2 human Angiotensin-converting enzyme humans in silico Increased indicated infect infectious Infectivity MDs molecular dynamics Molecular dynamics simulation molecular dynamics simulations mutant Mutation nonsynonymous Novel coronavirus pandemic of COVID-19 pangolin pangolin CoV phase Phylogenetic analysis provide Pseudotyped virus RBD RBD mutation RBD mutations receptor Receptor binding Receptor-binding domain (RBD) Recombination Research respiratory SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 RBD SARS-CoV-2 spike protein SARS-CoV-2 variant selection pressure severe acute respiratory syndrome Coronavirus spike spike mutation spike mutations Spike protein Support surface plasmon surface plasmon resonance Surveillance sustained the RBD the SARS-CoV-2 trajectory Transmission V367F Vaccine Vaccines variant variants Viral viral infectivity viral tropism zoonotic infections zoonotic origin [DOI] 10.1128/JVI.00617-21 PMC 바로가기 [Article Type] Virus-Cell Interactions
Genome-Wide Variation in BetacoronavirusesGenetic Diversity and Evolution Published on 2021-05-122022-10-30 Journal: Journal of Virology [Category] COVID-19, [키워드] acute respiratory syndrome Analysis antibody Antiviral antiviral drugs bat Betacoronavirus biological property Combination contributing to coronavirus COVID-19 Critical Defense diagnostic test diagnostic tests disorder Evolution form Genetic Genome genomic variation genus Betacoronavirus glycoprotein S highlight homologous Host host adaptation humans implication include infect Infection infection with SARS-CoV-2 manifested MERS-CoV Middle East Mutation natural new strain ORF1b ORF8 Other pathogenicity Probability profile property Protein protein S provide reliability repeated Replication respiratory syndrome coronavirus S glycoprotein S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 strain selection pressure strain Strains Trigger Vaccine Vaccine design Variation virus [DOI] 10.1128/JVI.00496-21 PMC 바로가기 [Article Type] Genetic Diversity and Evolution