senescence

[키워드] accumulate acute respiratory syndrome adverse outcome age amplify amplifying antibody Antibody Response Antiviral antiviral antibodies antiviral gene Apoptosis approach asked biopsies blunt caused Cell cell fate cells cellular cellular senescence changes in chronic disease Chronic diseases chronic inflammation Complete contribute coronavirus COVID-19 COVID-19 pandemic Cytokine storm Dasatinib decrease Defense drug dysfunction Effect elicited eliminated endothelial ENhance event expression Factors Gene Expression Genetic Human human cell human lung hyperinflammation Hyperinflammatory Hypothesis IFITM immune response IMPROVE in vivo increase increase in increased expression increased risk individual Infection Inflammation Inflammatory marker inflammatory protein LPS Lung epithelial cells mechanism metabolism MHV mice microbial morbidity and mortality morphology Mortality mouse hepatitis virus multi-organ failure obesity occur organ organism outcome PAMP PAMPs paracrine pathogen pathogen-associated molecular pathogen-associated molecular pattern pathogenic phenotype pro-inflammatory pro-inflammatory factors PROTECT Protein protein expression reduce reduce mortality reduced reducing regimen Resilience response resulting SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 spike SARS-CoV-2 spike protein SASP secrete Secretome senescence senescent senescent cell serum significantly significantly increased SPF Stress Support susceptibility targeting tissue transferred treat treated treating viral entry viral infection viral pathogen β-coronavirus
[DOI] 10.1126/science.abe4832 PMC 바로가기 [Article Type] Article