Antibody-Dependent Enhancement of SARS-CoV-2 Infection of Human Immune Cells: In Vitro Assessment Provides Insight in COVID-19 PathogenesisArticle Published on 2021-12-112022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ADE ADE effect antibody Antibody-dependent enhancement assessment association collected condition conducted convalescent serum COVID-19 COVID-19 pathogenesis COVID-19 patients demonstrated Dilution dysregulated enhancement exacerbate excessive immune response Express Factor FcγR Gene Expression Host Human immune immune cells in vitro Infection insight Macrophage medium Monocytes Neutralizing titer patients positively correlated primary B cells provide raise RBD SARS-CoV-2 SARS-COV-2 infection serum sample severe lung pathology Severe patient Severity of disease viral antibody viral gene with COVID-19 [DOI] 10.3390/v13122483 PMC 바로가기 [Article Type] Article
Association between serum inflammatory parameters and the disease severity in COVID‐19 patientsCOVID -19 환자의 혈청 염증 파라미터와 질병 중증도 사이의 연관성Research Article Published on 2021-12-072022-08-31 Journal: Journal of Clinical Laboratory Analysis [Category] 바이오마커, [키워드] age analyzed Blood blood test blood tests C‐reactive protein causative agent clinician correlation count COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 criteria CRP Cytokines develop diagnosed difference disease disease severity enrolled erythrocyte sedimentation erythrocyte sedimentation rate ESR evaluate Gender groups help ICU admission IL‐6 IL‐6 increase in Inflammatory cytokine Inflammatory cytokines Inflammatory marker inflammatory markers inflammatory parameter Iran lymphocyte Lymphocytes marker measurement mild symptoms MONITOR Most patient Most patients neutrophil Neutrophils no significant difference Novel coronavirus objective Patient patients predict Prognosis Result SARS‐CoV‐2 SARS‐CoV‐2 sedimentation rate serum Serum level serum levels severe cases severe group Severe patient severe patients severity severity and prognosis significant decrease significant difference significant differences significantly higher the disease TNF‐α TNF‐α two group two groups [DOI] 10.1002/jcla.24162 PMC 바로가기 [Article Type] Research Article
Longitudinal Metabolomics Reveals Ornithine Cycle Dysregulation Correlates With Inflammation and Coagulation in COVID-19 Severe PatientsMicrobiology Published on 2021-12-032022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] amino acid metabolism amino acids analyzed association biochemical Biochemical parameters Blood change Coagulation correlated COVID-19 COVID-19 patient COVID-19 patients creating cycle cytokine Cytokines diagnostic dipeptides discharge Disease progression drug dysregulation FIVE global pandemic humans Inflammation longitudinal longitudinal change marker metabolic disorder metabolic factor metabolite metabolites metabolome metabolomic metabolomics Mild nine ornithine ornithine cycle pathogenic mechanisms pathogenicity peptides potential mechanism provided SARS-CoV-2 SARS-COV-2 infection serum severe disease Severe patient severe patients significantly significantly higher valuable resource [DOI] 10.3389/fmicb.2021.723818 PMC 바로가기 [Article Type] Microbiology
Effect of IL-6, IL-8/CXCL8, IP-10/CXCL 10 levels on the severity in COVID 19 infectionIL-6, IL-8/CXCL8, IP-10/CXCL 10 수준이 COVID 19 감염의 중증도에 미치는 영향Article Published on 2021-12-012022-09-11 Journal: International journal of clinical practice [Category] MERS, SARS, 바이오마커, [키워드] affected albumin biochemical parameter Biochemical parameters Biomarkers correlation COVID 19 COVID 19 patients COVID-19 patient COVID-19 patients CRP CXCL10 CXCL8 D-dimer dimer disease Effect examined group groups healthy volunteer healthy volunteers highest IL-6 IL-6 level IL-6 levels IL-8 IL6 Infection IP-10 IP10 Laboratory marker MERS parameter Patient PCT positive correlation predict Prognosis prognostic indicator progression Protein SARS-COV-2 infection SARS-CoV-2 infections sedimentation serum Severe patient severity significantly statistical analysis statistically significant difference the disease the healthy total protein Volunteer WBC were assessed [DOI] 10.1111/ijcp.14970 PMC 바로가기 [Article Type] Article
Efficacy of Ninjin’yoeito in treating severe coronavirus disease 2019 in patients in an intensive care unit집중 치료실의 환자에서 심각한 코로나 바이러스 질환 2019 치료에서 닌자 yoeito의 효능Article Published on 2021-12-012022-08-31 Journal: Neuropeptides [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Admission body mass body mass index Care Chronic kidney disease clinical trial Comorbidity conducted coronavirus coronavirus disease coronavirus disease-2019 Coronavirus-2 COVID-19 diabete diabetes effective enrolled enteral nutrition evaluate examined followed by groups high mortality hospital Hospital stay hypertension ICU ICU patient ICU Patients IMV Infectious disease intensive care intensive care unit Invasive mechanical ventilation Japanese Kampo Kidney disease management median median age men mortality rate Ninjin'yoeito nutrition participant Patient patients Pneumonia prognostic Prognostic nutritional index respiratory SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe coronavirus disease severe COVID-19 Severe patient significantly the median tracheostomy treated with COVID-19 women [DOI] 10.1016/j.npep.2021.102201 PMC 바로가기 [Article Type] Article
Plasma gp96 is a Novel Predictive Biomarker for Severe COVID-19혈장 gp96은 심한 covid-19에 대한 새로운 예측 바이오 마커입니다.Research Article Published on 2021-11-242022-08-31 Journal: Microbiology Spectrum [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory illness analyzed coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID‐19 Critical DAMPs danger-associated molecular pattern danger-associated molecular patterns disease disease severity effective elevated evaluate Fever Heat shock heat shock protein heat shock proteins hospital Hospitalization Hsps IL-6 IMPROVE indicated Injury interleukin interleukin-6 less Mild monocyte Monocytes non-COVID-19 patient Non-COVID-19 patients novel outcome oxidative stress patients patients with COVID-19 plasma plasma concentration plasma concentrations plasma gp96 poor prognosis positively correlated predicted Predictive predictive biomarker prognostic biomarker Protein released respiratory Respiratory illness respiratory impairment respiratory symptoms severe coronavirus disease severe COVID-19 Severe patient severe patients significantly significantly higher Viral viral infection with COVID-19 [DOI] 10.1128/Spectrum.00597-21 PMC 바로가기 [Article Type] Research Article
Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in JapanCardiovascular Medicine Published on 2021-11-192022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] 95% confidence interval adjusted odds ratio Admission age Analysis analyzed anticoagulation antiinflammatory arterial Biomarker bleeding center characteristic Clinical course Clinical symptoms Coagulopathy comparable Complication conditions coronavirus disease COVID-19 COVID-19 patients D-dimer dental diagnosed E484K elevated epidemiological data event ferritin level high-risk population identify incidence independent risk factor Intervention Japan Japanese L452R Laboratory less management marker mortality rate mutant N501Y occurred organ dysfunctions Oxygen therapy pathology Patient patients patients with COVID-19 proportion radiological required risk factor SARS-CoV-2 SARS-CoV-2 variant Severe patient strain the patient the spike protein therapy Thromboembolic events thrombosis thrombotic complication thrombotic event Thrombotic events Tokyo university variant variant of concern venous Venous thrombosis while with COVID-19 [DOI] 10.3389/fcvm.2021.767074 PMC 바로가기 [Article Type] Cardiovascular Medicine
Clinical Features and Laboratory Examination to Identify Severe Patients with COVID-19: A Systematic Review and Meta-AnalysisReview Article Published on 2021-11-152022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, [키워드] Analysis C-reactive protein cardiovascular disease Chest China Chinese chronic renal disease chronic respiratory clinical clinical factor clinical feature Comorbidities contribute cough COVID-19 COVID-19 epidemic COVID-19 patients database diagnosed Diagnosis diarrhea disease early stage erythrocyte sedimentation rate examination exhibited Fever headache Infection information Laboratory likelihood likelihood ratio Lymphocytes neutrophil Odds ratio Patient patients with COVID-19 positive predict Prevalence Probability progression Publication bia reduce mortality Result review searched sensitivity sensitivity analysis Severe patient severe patients Shortness of breath specificity Symptom Web of Science were assessed [DOI] 10.1155/2021/6671291 PMC 바로가기 [Article Type] Review Article
ARB might be superior to ACEI for treatment of hypertensive COVID‐19 patientsLetter to the Editor Published on 2021-11-112022-10-29 Journal: Journal of Cellular and Molecular Medicine [Category] COVID-19, [키워드] ACEi administration alleviate Ang II ARB attenuate benefit blockers Clinical outcome conditions coronavirus disease COVID‐19 COVID‐19 patient COVID‐19 patients COVID‐19 enzyme exhibit Guidance hypertension hypertensive IMPROVE Infection inflammatory reaction lower risk Lung fibrosis mechanical ventilation Mortality no effect offer Patient Prognosis question receiving receptor retrospective severe ARDS Severe patient significantly Treatment [DOI] 10.1111/jcmm.17051 PMC 바로가기 [Article Type] Letter to the Editor
Definitions and elements of endpoints in phase III randomized trials for the treatment of COVID-19: a cross-sectional analysis of trials registered in ClinicalTrials.govCOVID-19 치료를 위한 3상 무작위 시험에서 평가변수의 정의 및 요소: ClinicalTrials.gov에 등록된 시험의 횡단면 분석Research Published on 2021-11-082022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] achievement allocation Analysis Characteristics of endpoints Clinical course clinical trial clinical trials collected condition conducted Consensus COVID-19 COVID-19 treatments cross-sectional analysis Definition Diseases downloaded element Endpoint endpoints examined facilitate Frame inclusion criteria Infectious diseases information median non-severe patient non-severe patients phase Phase III trials primary endpoints Primary outcome measures provide randomized trial Registered Result Sample size secondary secondary endpoint secondary outcome measures selected severe and non-severe patients Severe patient severe patients severity time Time frame time frames transcribed Treatment Trial worsening [DOI] 10.1186/s13063-021-05763-y PMC 바로가기 [Article Type] Research