Associations between body-mass index and COVID-19 severity in 6·9 million people in England: a prospective, community-based, cohort study영국의 6·900만 인구의 체질량 지수와 COVID-19 심각도 사이의 연관성: 전향적, 지역사회 기반, 코호트 연구Articles Published on 2021-06-012022-09-12 Journal: The lancet. Diabetes & endocrinology [Category] Fulltext, MERS, 진단, [키워드] adjusted adjusted hazard ratio Admission adverse outcome adverse outcomes age association available data behavioural black black people BMI body-mass cardiovascular disease Characteristics cohort study Comorbidities conditions COVID-19 COVID-19 severity Cox proportional hazard models database death demographic characteristics diabetes died Diseases eligible England Ethnicity Factors finding for inclusion funding Health hospital Hospital admission hypertension ICU ICU admission increase in individual Infection infection with SARS-CoV-2 intensive care intensive care unit Interaction linear morbidities nadir NIHR notable obesity office Older Oxford Patient positive Positive test Public Health England QResearch recorded Registered Relative risk risk risk factor SARS-CoV-2 SARS-CoV-2 test severe COVID-19 significant interaction Statistics type 2 diabetes White people younger people [DOI] 10.1016/S2213-8587(21)00089-9 PMC 바로가기 [Article Type] Articles
Lives versus Livelihoods? Perceived economic risk has a stronger association with support for COVID-19 preventive measures than perceived health riskArticle Published on 2021-05-062022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] added association collected Compliance coronavirus country covariate COVID-19 Effect Effects examined Health Health care implication individual interaction effect measure pandemic Perceived Perceived risk positive predicted predictor preventive measure Psychology regression models Result risk Risk factors significant interaction Support variable with COVID-19 [DOI] 10.1038/s41598-021-88314-4 PMC 바로가기 [Article Type] Article
Proteinuria changes in kidney disease patients with clinical remission during the COVID-19 pandemicResearch Article Published on 2021-04-232022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] age analyzed blood pressure Care change changes in Chronic kidney disease CKD clinical feature clinical variable Complete coronavirus disease COVID-19 COVID-19 pandemic evaluated female Immunosuppression independent variable inhibitor Kidney disease maintenance dose multivariable analyses Odds ratio outpatient clinic pandemic Patient patients patients treated primary outcome measure Protein Proteinuria RAASi receiving reduced reduction Result significant interaction Support Therapeutic approach therapy Tokyo university hospital variable was used [DOI] 10.1371/journal.pone.0250581 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Receptor ACE2 Gene Is Associated with Hypertension and Severity of COVID 19: Interaction with Sex, Obesity, and SmokingSARS-CoV-2 수용체 ACE2 유전자는 고혈압 및 COVID 19의 심각성과 관련이 있습니다: 성, 비만 및 흡연과의 상호 작용Article Published on 2021-04-202022-09-11 Journal: American journal of hypertension [Category] SARS, 변종, [키워드] 95% confidence interval ACE2 ACE2 gene ACE2 variant ACE2 variants acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association Blood blood pressure both sexes cause Comorbidity condition conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 severity entry receptor enzyme females genetic analysis Genotype human cells hypertension individual individuals Interaction male males non-survivor nucleotide obese obesity outcome polymorphism populations risk allele risk factor rs233575 SARS-CoV-2 SARS–CoV-2 several variants severe acute respiratory syndrome Coronavirus severity Sex Significant significant interaction significantly single nucleotide Single nucleotide polymorphism smoking T allele tested UK biobank variant with COVID-19 [DOI] 10.1093/ajh/hpaa223 PMC 바로가기 [Article Type] Article
Impact of diabetes in patients waiting for invasive cardiac procedures during COVID-19 pandemicCOVID-19 전염병 동안 침습적 심장 시술을 기다리는 환자에서 당뇨병의 영향Multicenter Study Published on 2021-03-232022-09-12 Journal: Cardiovascular Diabetology [Category] 진단, [키워드] cardiovascular risk factors clinical conditions Clinical outcome clinical variables co-morbidities consequence COVID-19 COVID-19 pandemic diabete diabetes diabetics difference disease higher impact hospital ICP identify Impact independent risk factor Interventional cardiology invasive Mortality multivariable analysis objective Older Patient patients with diabetes Prevalence remained Result significant interaction Spain subgroup valvular Waiting list [DOI] 10.1186/s12933-021-01261-2 PMC 바로가기 [Article Type] Multicenter Study
Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients폐동맥 고혈압 환자에서 복잡성을 만드는 SARS-CoV-2 감염에 대한 바이오마커 및 경로 식별Article Published on 2021-03-222022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis Arterial hypertension Biomarker carried caused Compound conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic diagnosed differentially expressed gene EDN1 effective drugs epithelial cell epithelial cells Evidence evidence of expression level expression profiling Extensive gene expression profile Gene expression profiling Gene ontology genomic Genomic analysis human lung human lung epithelial cells hypertension identification identify immune response Infection infections Inflammatory response Inflammatory responses integration lung observation Ontology PAH pathway Patient performed Phylogenetic tree promoter protein-protein interaction provided pulmonary arterial hypertension Regulatory Research respiratory response Ribonucleic acid RNA virus RNA viruses S100A12 S100A8 S100A9 Saa1 SAA2 SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections severe acute respiratory syndrome Coronavirus Signaling signaling pathway signaling pathways significant interaction the SARS-CoV-2 therapeutic these compound these compounds transcriptomic Transcriptomic analyses transcriptomic analysis Transcriptomic profiling Transferrin viruses [DOI] 10.1093/bib/bbab026 PMC 바로가기 [Article Type] Article
Adjustment to a “New Normal:” Coping Flexibility and Mental Health Issues During the COVID-19 PandemicPsychiatry Published on 2021-03-192022-10-31 Journal: Frontiers in Psychiatry [Category] COVID-19, [키워드] adaptation adaptive Adjustment age Anxiety association center Chinese conducted coping Coping strategy coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic criteria defined Depression Epidemic flexibility Health Hong Kong interview investigated issue likelihood mental health pandemic Perception personal health problems Psychological well-being Reactions Resilience scale schedule significant interaction Stress were assessed [DOI] 10.3389/fpsyt.2021.626197 PMC 바로가기 [Article Type] Psychiatry
Association and Interaction Between Serum Interleukin-6 Levels and Metabolic Dysfunction-Associated Fatty Liver Disease in Patients With Severe Coronavirus Disease 2019Endocrinology Published on 2021-03-082022-10-31 Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS, [키워드] 95% CI Admission age age and sex association Chinese hospital circulating co-morbidities Computed tomography coronavirus COVID-19 cytokine diagnosed disease elevated enrolled Fatty liver higher risk Hospital admission IL-10 IL-2 IL-4 IL-6 IL-6 level infected patient Inflammatory cytokine Interaction interferon laboratory-confirmed Level MAFLD median metabolic NAFLD Necrosis Patient remained Result risk SARS-CoV-2 screened serum severe COVID-19 Sex significant interaction were measured [DOI] 10.3389/fendo.2021.604100 PMC 바로가기 [Article Type] Endocrinology
Sex Differences on Clinical Characteristics, Severity, and Mortality in Adult Patients With COVID-19: A Multicentre Retrospective StudyMedicine Published on 2021-02-122022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95% CI Acute cardiac injury addition age age and sex China clinical Comorbidity COVID-19 COVID-19 patients Cox regression Cox regression analysis difference Epidemic epidemiological data Estrogen fatality female female patient females high-density hospital identify in-hospital mortality incidence rate independent risk factor Interaction involved lymphocyte male Male sex mechanism men Menopause Mortality multicentre multivariate multivariate Cox regression no difference outcome Patient patients performed protein level retrospective cohort study risk factor severity Sex Sex difference significant interaction significantly Stratification was determined with COVID-19 women [DOI] 10.3389/fmed.2021.607059 PMC 바로가기 [Article Type] Medicine
Effects of tocilizumab on mortality in hospitalized patients with COVID-19: a multicentre cohort studyCOVID-19로 입원한 환자의 사망률에 대한 토실리주맙의 효과: 다기관 코호트 연구Multicenter Study Published on 2021-02-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 진단, 치료기술, [키워드] 95% confidence interval adjusted adjusted hazard ratio Admission analysed Analysis association baseline C-reactive protein C-reactive protein (CRP causal relationship clinical trial clinical trials cohort study control group coronavirus disease Coronavirus disease 2019 covariate COVID-19 CRP CRP levels death deaths determine Effect Efficacy Exploratory subgroup analyses hazard ratio hospitalized patient hospitalized patients ICU ICU admission implication intensive care intensive care unit investigated large cohort lower risk Mortality multicentre observational study outcome Patient patients hospitalized patients with COVID-19 point estimate point estimates Primary outcome Probability receipt risk of death SARS-CoV-2 secondary outcome severe coronavirus disease significant interaction Spain systemic inflammation therapy Tocilizumab Weighting while with COVID-19 [DOI] 10.1016/j.cmi.2020.09.021 PMC 바로가기 [Article Type] Multicenter Study