Small-molecule metabolome identifies potential therapeutic targets against COVID-19소분자 대사체는 COVID-19에 대한 잠재적인 치료 표적을 식별합니다Article Published on 2022-06-152022-09-12 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] Accuracy biochemical change characterized composed Concentration controls COVID-19 COVID-19 infected individual COVID19 COVID19 patient disease severity evaluate host cell identify Infection metabolome metabolomic signature microbes nasal nasal mucosa nasopharyngeal Patient potential therapeutic target potential therapeutic targets primer produced qRT-PCR R 2 respiratory respiratory syncytial virus RSV SARS-CoV-2 significantly significantly increased small molecule tested transmitted unique viral infection Viral load virus [DOI] 10.1038/s41598-022-14050-y PMC 바로가기 [Article Type] Article
Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (M pro) inhibitorsSARS-CoV-2 주요 프로테아제(M pro) 억제제에 대한 전향적 납 지지체로서의 알로에 유래 천연물 식별Article Published on 2022-06-152022-09-11 Journal: Bioorganic & medicinal chemistry letters [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL(pro) active site Aloe aloeresin D. Aloesin Analysis Antiviral approval binding energy catalytic caused Compound COVID-19 pandemic death demonstrated dose response curve dose response curves drug target effort enzyme FIVE Follow-up HCV Hill HIV identification identify in vitro Infection inhibitor inhibitors kinetic knowledge M pro M(pro) molecular molecular docking studies Molecular docking study natural natural products new SARS-CoV-2 offer protease Protease inhibitor protease inhibitors retrieved SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 variants screened small molecule structure-function TCID Therapies vaccination variants viruses [DOI] 10.1016/j.bmcl.2022.128732 PMC 바로가기 [Article Type] Article
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021) Reviews Published on 2022-06-092022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 치료제, [키워드] addition Cancer catalytic Chimera Clinical treatment Compound Degradation disease Diseases immune disorders increase in induce introduced knockdown molecular neurodegenerative problem Protein rapid increase reported Research researcher small molecule target target protein unique viral infections [DOI] 10.1038/s41392-022-00999-9 [Article Type] Reviews
The Correlation Between Immune Invasion and SARS-COV-2 Entry Protein ADAM17 in Cancer Patients by Bioinformatic AnalysisArticle Published on 2022-06-032023-07-09 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] ADAM17 Cancer SARS-CoV-2 small molecule susceptibility Therapeutics [DOI] 10.3389/fimmu.2022.923516 PMC 바로가기
Inhibition of SARS-CoV-2 replication by zinc gluconate in combination with hinokitiol히노키티올과 함께 글루콘산아연에 의한 SARS-CoV-2 복제 억제Article Published on 2022-06-012022-09-11 Journal: Journal of inorganic biochemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro acute respiratory syndrome coronavirus antiviral therapy approach binding catalytic site chymotrypsin Combination Concentration coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 elevated Enzyme inhibition exhibited experimental evidence global public health gluconate hinokitiol in vitro inhibit inhibited inhibition inhibitory Ionophore mammalian cells metal ion MPro pandemic Papain Papain-like protease PLPro potential benefit potential benefits protease Protease activity Proteases protein structure proteolytic proteolytic activity residues respiratory SARS-CoV-2 SARS-CoV-2 replication screened Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 significantly small molecule target Treatment Zinc zinc gluconate Zinc gluconate. [DOI] 10.1016/j.jinorgbio.2022.111777 PMC 바로가기 [Article Type] Article
Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategyResearch article Published on 2022-05-172022-10-05 Journal: Computational and Structural Biotechnology Journal [Category] 신약개발, 치료법, 치료제, [키워드] activate acute respiratory syndrome antibiotic applied approach binding can be used cathepsin cathepsin L cleave clinically coronavirus coronavirus disease COVID-19 CTSL cysteine protease Daptomycin deep learning drug Drug discovery drug prediction enzyme expand FDA-approved drug identify Infection inhibit inhibit SARS-CoV-2 inhibitor inhibitory effect live SARS-CoV-2 molecular docking novel molecule other disease Potential predict pseudotype pseudovirus infection robust SARS-CoV-2 significantly small molecule Spike protein suggested therapeutic target these compound Treatment Z-FA-FMK [DOI] 10.1016/j.csbj.2022.05.023 [Article Type] Research article
Seroconversion to mRNA SARS-CoV-2 Vaccines in Hematologic Patients혈액학적 환자에서 mRNA SARS-CoV-2 백신으로의 혈청전환Article Published on 2022-05-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] 95% CI acute leukemia acute myeloid leukemia Algorithm Analysis Anti-spike BNT162b2 chronic lymphocytic leukemia CLL COVID-19 Diagnosis disorders hematologic IgG IgG level IgG levels indolent Italy lack leukemia Lymphocytic leukemia lymphoma Moderna monoclonal antibodies mRNA mRNA vaccination mRNA-1273 Multiple myeloma multivariable analysis myelofibrosis myeloproliferative disorders myeloproliferative disorders. Neoplasms normal range Patient patients Pfizer Pfizer-BioNTech predict predictor prospective cohort study receiving response risk factor ruxolitinib SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines Seroconversion seroconverted simple algorithm single center small molecule Small molecules therapy treated Treatment vaccine administration vaccine dose venetoclax [DOI] 10.3389/fimmu.2022.852158 PMC 바로가기 [Article Type] Article
Evaluation of Antibody Response to SARS-CoV-2 mRNA-1273 Vaccination in Patients With Cancer in Florida플로리다의 암 환자에서 SARS-CoV-2 mRNA-1273 백신 접종에 대한 항체 반응 평가Article Published on 2022-05-012022-09-12 Journal: JAMA Oncology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI age anti-CD20 anti-CD20 treatment antibody Antibody Response applied blood test calculated Cancer cancer diagnosis cancer type cohort study diagnose dose doses English enzyme-linked immunosorbent Factor geometric mean titer hematologic Hispanic IgG IgG level Immunosuppressive treatment individual lowest lymphocyte lymphoid monoclonal antibody treatment morbidity and mortality mRNA-1273 Older outcome participant Patient patients treated Patients with cancer receipt receiving response SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 vaccine Seroconversion Seropositivity significantly lower small molecule solid tumor Spanish T Test treated Treatment vaccination vaccine dose vaccine response white [DOI] 10.1001/jamaoncol.2022.0001 PMC 바로가기 [Article Type] Article
Combination of QSAR, molecular docking, molecular dynamic simulation and MM-PBSA: analogues of lopinavir and favipiravir as potential drug candidates against COVID-19QSAR, 분자 도킹, 분자 동적 시뮬레이션 및 MM-PBSA의 조합: COVID-19에 대한 잠재적 약물 후보로서 로피나비르 및 파비피라비르의 유사체Article Published on 2022-05-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] Absorption active site analogue Analysis anti-viral drug Anti-viral drugs binding affinity candidate Candidates Compound COVID-19 COVID-19 infection COVID-19 infections demonstrated disease distribution docked complex docking drug candidate druggability effective enzyme Enzymes Favipiravir feature form identify IMPROVE in vitro inhibit Interaction less Lopinavir M pro metabolism Modification molecular molecular docking molecular dynamic simulations molecular dynamics Molecular dynamics simulation novel drug physicochemical polyprotein polyproteins processing protease QSAR Quantitative RdRP Replication residue RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 selected shown significantly small molecule Small molecules Spread stable complex Toxicity trajectory translated Treatment Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1080/07391102.2020.1850355 PMC 바로가기 [Article Type] Article
Use of hyphenated analytical techniques to identify the bioactive constituents of Gunnera perpensa L., a South African medicinal plant, which potently inhibit SARS-CoV-2 spike glycoprotein-host ACE2 bindingSARS-CoV-2 스파이크 당단백질-숙주 ACE2 결합을 강력하게 억제하는 남아프리카 공화국의 약용 식물인 Gunnera perpensa L.의 생리 활성 성분을 식별하기 위한 하이픈 연결 분석 기술의 사용Article Published on 2022-05-012022-09-11 Journal: Analytical and bioanalytical chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 ACE2 binding African angiotensin Angiotensin-converting enzyme Antiviral antivirals binding causative agent cellular entry Compound Concentration COVID-19 described disrupt domain glycoprotein Gunnera Gunnera perpensa harmonization highlight Host hypothesised identify inhibit inhibit SARS-CoV-2 Interaction International Conference lack management morbidity and mortality neutralising antibody plant Protein Punicalagin Punicalin RBD RBD-ACE2 receptor Region REGN10987 SARS-CoV-2 SARS-COV-2 infection small molecule Small molecules South spike glycoprotein Spread UPLC UPLC-IMS-HRMS. Vaccines viral spike [DOI] 10.1007/s00216-022-04041-3 PMC 바로가기 [Article Type] Article