Structure-Based Virtual Screening and Identification of Potential Inhibitors of SARS-CoV-2 S-RBD and ACE2 InteractionChemistry Published on 2021-09-272022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] ACE2 Angiotensin-converting enzyme 2 (ACE2) antiviral activity binding caused Compound Concentration demonstrated described experimental validation identification inhibitor inhibitors Interaction Potential protein-protein interaction (PPI) inhibitors pseudovirus public health crisis reported S-RBD SARS-CoV-2 Screening small molecule inhibitor spike protein receptor-binding domain (S-RBD) SPR Spread Structure-based virtual screening Treatment Virtual screening [DOI] 10.3389/fchem.2021.740702 PMC 바로가기 [Article Type] Chemistry
Targeting novel coronavirus SARS-CoV-2 spike protein with phytoconstituents of Momordica charantiaMomordica Charantia의 식물성 분열제를 갖는 소설 코로나 바이러스 SARS-COV-2 스파이크 단백질 표적Research Published on 2021-09-272022-08-31 Journal: Journal of Ovarian Research [Category] SARS, 변종, 치료제, [키워드] active site ADME Affect binding binding affinity binding energy Bitter Bitter melon component Compound COVID-19 docking Docking studies docking study domain drug effort Erythrodiol evaluate hydrophilic hydrophobic hydrophobic interactions identify in-silico infection rate Interaction Melon Momordica Momordica Charantia novel coronavirus SARS-CoV-2 PyMol reduce Result reveal S1 and S2 S1 and S2 domains SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 viral infection SARS-CoV-2 virus selection pressure Spike protein Spike proteins SPR strong interactions surface plasmon surface plasmon resonance targeting tested the SARS-CoV-2 the SARS-CoV-2 virus the spike protein treat vaccination variant Viral viral infections was used were used [DOI] 10.1186/s13048-021-00872-3 PMC 바로가기 [Article Type] Research
Surface plasmon resonance aptasensor based on niobium carbide MXene quantum dots for nucleocapsid of SARS-CoV-2 detectionSARS-CoV-2 검출의 뉴클레오캡시드를 위한 니오븀 카바이드 MXene 양자점 기반 표면 플라즈몬 공명 앱타센서Article Published on 2021-09-022022-09-11 Journal: Mikrochimica Acta [Category] SARS, 치료기술, 치료법, 치료제, [키워드] Analysis aptamer aptasensor changed complex Concentration construction Contact covalent binding detect detection Detection of N-gene distance followed by gold high stability human serum Interaction Laser limit of detection N-gene Nb2C MXene quantum dot niobium nucleocapsid Protein qualitative analysis Quantum dot respiratory virus resulting SARS-CoV-2 SARS-CoV-2 detection Seafood Seawater sensor SPR surface plasmon surface plasmon resonance Surface plasmon resonance biosensor. thiol wavelength [DOI] 10.1007/s00604-021-04974-z PMC 바로가기 [Article Type] Article
Surface Plasmon Resonance (SPR)- and Localized SPR (LSPR)-Based Virus Sensing Systems: Optical Vibration of Nano- and Micro-Metallic Materials for the Development of Next-Generation Virus Detection TechnologyReview Published on 2021-07-262022-10-27 Journal: Biosensors [Category] COVID-19, [키워드] amplification biosensing conducted COVID-19 pandemic detection development early stage effective false-negative False-positive in some limitation Localized localized SPR material micro-scale nano nanoscale pandemic Patient Plasmon prevalent Prevent reported resonance response SPR Spread surface surface plasmon resonance technology thought Vibration viral infection Viral load virus virus detection virus sensing widespread [DOI] 10.3390/bios11080250 PMC 바로가기 [Article Type] Review
Surface Plasmon Resonance (SPR)- and Localized SPR (LSPR)-Based Virus Sensing Systems: Optical Vibration of Nano- and Micro-Metallic Materials for the Development of Next-Generation Virus Detection TechnologyReview Published on 2021-07-262022-10-27 Journal: Biosensors [Category] Coronavirus, COVID-19, SARS, [키워드] amplification biosensing conducted COVID-19 pandemic detection development early stage effective false-negative False-positive in some limitation Localized localized SPR material micro-scale nano nanoscale pandemic Patient Plasmon prevalent Prevent reported resonance response SPR Spread surface surface plasmon resonance technology thought Vibration viral infection Viral load virus virus detection virus sensing widespread [DOI] 10.3390/bios11080250 PMC 바로가기 [Article Type] Review
SPR-Based Kinetic Analysis of the Early Stages of Infection in Cells Infected with Human Coronavirus and Treated with HydroxychloroquineArticle Published on 2021-07-262022-10-27 Journal: Biosensors [Category] COVID-19, [키워드] antiviral drug antiviral response assays biochemical Cell cell interaction cell layer cell-based assay cells coronavirus dead cells Drug discovery early stage effective human coronavirus Hydroxychloroquine infected cells Infection inhibitors Interaction kinetic analysis Mask mechanism of action MTT physiological predict Replication SPR SPR assay Stage time interval treated viral growth viral growth kinetics viral infection was measured was used were infected [DOI] 10.3390/bios11080251 PMC 바로가기 [Article Type] Article
SPR-Based Kinetic Analysis of the Early Stages of Infection in Cells Infected with Human Coronavirus and Treated with HydroxychloroquineArticle Published on 2021-07-262022-10-27 Journal: Biosensors [Category] Coronavirus, COVID-19, [키워드] antiviral drug antiviral response assays biochemical Cell cell interaction cell layer cell-based assay cells coronavirus dead cells Drug discovery early stage effective human coronavirus Hydroxychloroquine infected cells Infection inhibitors Interaction kinetic analysis Mask mechanism of action MTT physiological predict Replication SPR SPR assay Stage time interval treated viral growth viral growth kinetics viral infection was measured was used were infected [DOI] 10.3390/bios11080251 PMC 바로가기 [Article Type] Article
Identification of Potential Binding Sites of Sialic Acids on the RBD Domain of SARS-CoV-2 Spike ProteinChemistry Published on 2021-07-222022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] ACE2 acid acute respiratory syndrome Analysis auxiliary binding binding site caused coronavirus COVID-19 determine DPP4 glycoprotein host cell human cells humans identification Interaction MERS-CoV Middle East molecular pandemic Penetrating Potential predominant probe question RBD RBD domain receptor respiratory SARS-CoV-2 sequence sialic acid Site spike Spike protein SPR the RBD the spike protein virus infection viruses [DOI] 10.3389/fchem.2021.659764 PMC 바로가기 [Article Type] Chemistry
Presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during CoViD-19 infectionCoViD-19 감염 중 SARS-CoV-2에 대한 IgM, IgG 및 IgA 항체의 존재 및 결합 강도Article Published on 2021-07-012022-09-12 Journal: Biosensors & bioelectronics [Category] SARS, 진단, [키워드] affinity anti-RBD antibody binding biosensor Course determine healthy individual IgA IgA antibody IgA level IgG IgG level IgM immune reaction Immune status Immunoglobulin Infection measure Off-rate off-rate. Patient patients Plasmon Presence provide RBD recovered resonance SARS-CoV-2 sera SPR surface surface plasmon resonance Surface plasmon resonance imaging the disease the RBD the RBD protein turn vaccination was used [DOI] 10.1016/j.bios.2021.113165 PMC 바로가기 [Article Type] Article
High throughput surface plasmon resonance imaging method for clinical detection of presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during CoViD-19 infectionMethod Article Published on 2021-06-292022-10-04 Journal: MethodsX [Category] 치료기술, [키워드] Abstract affinity Affinity maturation Analysis anti-RBD antibody Antibody binding antibody isotypes antibody profiling binding biosensor Concentration Corona Course determine healthy individual high throughput IgA IgA antibody IgA level IgG IgG level IgM Image immune reaction Immune status Immunoglobulin individual Infection Infectious diseases isotype measure mutant Off-rate Patient patients performed Plasmon polyclonal provide RBD recovered resonance SARS-CoV-2 Screening sera shown SPR surface the disease the RBD the RBD protein turn vaccination was used [DOI] 10.1016/j.mex.2021.101432 PMC 바로가기 [Article Type] Method Article