Metabolomic analyses reveal new stage-specific features of COVID-19대사체 분석은 COVID-19의 새로운 단계별 특징을 보여줍니다Article Published on 2022-02-242022-09-12 Journal: The European Respiratory Journal [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] affected Analysis approach caused characterisation circulating metabolite Cohort comprehensive view controls coronavirus disease Course COVID-19 COVID-19 patient COVID-19 progression Critical death disease feature Glucose identifying individual metabolism metabolomic analysis Mild molecular mechanism overcome pandemic pathological mechanism pathophysiological pathophysiology progression sera Stage stages the disease the healthy urea cycle validation cohort [DOI] 10.1183/13993003.00284-2021 PMC 바로가기 [Article Type] Article
Increased Expression of Tim-3 Is Associated With Depletion of NKT Cells In SARS-CoV-2 InfectionTim-3의 발현 증가는 SARS-CoV-2 감염에서 NKT 세포의 고갈과 관련이 있습니다Immunology Published on 2022-02-162022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis Apoptosis binding caspase caused CD147 CD26 Cell circulating coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients CTLA-4 DCs decrease demonstrated dendritic cell dendritic cells Depletion disease severity dysfunction expressed expression expression level Genes healthy individuals IFN-γ IL-10 IL-12 IL-4 immune responses Immunopathogenesis implication Increased increased expression LAG-3 large cohort mechanism mitochondrial mitochondrial gene mitochondrial genes natural killer NKT NKT cell NKT cells outcome patients with COVID-19 PD-1 positively correlated Prognosis progression stage promote receptor receptors respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike scRNA-seq secrete secreted Sequencing analysis severe acute respiratory syndrome Coronavirus severity and prognosis Single-cell RNA sequencing stages therapeutic strategy TIM-3 up-regulated [DOI] 10.3389/fimmu.2022.796682 PMC 바로가기 [Article Type] Immunology
Immune Cells Profiles in the Different Sites of COVID-19-Affected Lung Lobes in a Single PatientMedicine Published on 2022-02-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] alveolar Analysis analyzed AQP3 Basal cell basal cells COVID-19 COVID-19 disease cytokine determine died Diffuse alveolar damage FIVE help identify Immune cell immune cells immunohistochemistry increase in indications Inflammation Inflammatory response lobe lung lung lobe lung lobes moderate mRNA expression pathological pathophysiology pathway Patient patient with COVID-19 profile Protective RNA-sequencing SARS-CoV-2 severe inflammation Site stages tissue Ventilation Viral transmission virus [DOI] 10.3389/fmed.2022.841170 PMC 바로가기 [Article Type] Medicine
Identification of Hypericin as a Candidate Repurposed Therapeutic Agent for COVID-19 and Its Potential Anti-SARS-CoV-2 ActivityMicrobiology Published on 2022-02-102022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] activity acute respiratory syndrome agent Analysis anti-SARS-CoV-2 Antiviral Area bind candidate composed Compound confirmed case coronavirus country COVID-19 COVID-19 pandemic cultured cells cytotoxicity dose drug Drug repurposing enzyme evaluated Health high affinity Hypericin Hypericum identification in vitro model increase in infected cells inhibited maturation MM/PBSA MPro pathogenic Potential public health RdRP Region regulatory agency Replication rising RNA RNA polymerase SARS-CoV-2 Spread stages Still surface targets Treatment vaccination variant VERO-E6 Viral protein viral replication Virtual screening virus virus replication [DOI] 10.3389/fmicb.2022.828984 PMC 바로가기 [Article Type] Microbiology
Mortality and readmission rates among hospitalized COVID-19 patients with varying stages of chronic kidney disease: a multicenter retrospective cohortObservational Study Published on 2022-02-102022-10-04 Journal: Scientific Reports [Category] MERS, 임상, 치료법, [키워드] Admission adverse outcomes chronic Chronic kidney disease CKD clinician Cohort coronavirus disease COVID-19 COVID-19 patient death determine hospitalized COVID-19 patient hospitalized patient Infection Infectious diseases kidney Kidney disease kidney transplant Mortality multicenter multicenter cohort study Observational cohort study Odds ratio outcome Patient patients patients hospitalized PCR-confirmed performed prevalent ranged readmission retrospective cohort risk factor SARS-COV-2 infection severe COVID-19 severity Stage stages [DOI] 10.1038/s41598-022-06276-7 PMC 바로가기 [Article Type] Observational Study
An evaluation of community satisfaction with the government’s COVID-19 pandemic response in Aceh, IndonesiaResearch article Published on 2022-02-012022-10-05 Journal: International Journal of Disaster Risk Reduction [Category] 치료기술, [키워드] Aceh Asia collected Community Community satisfaction country COVID-19 COVID-19 pandemic criteria FIVE Government Government performance health system highest IMPROVE Indonesia inhibiting Local lowest mortality rate pandemic Rapid test recommendation Satisfaction sick Spread stages Vaccine WhatsApp while [DOI] 10.1016/j.ijdrr.2021.102723 [Article Type] Research article
The COVID-19 patients’ educational needs assessment questionnaire (COPENAQ): development and psychometricsResearch Published on 2022-01-292022-10-31 Journal: Health and Quality of Life Outcomes [Category] COVID-19, SARS, [키워드] Alpha Analysis approval conducted confirmatory factor analysis COVID-19 COVID-19 patient criteria Educational needs effective evaluated explained exploratory Exploratory factor analysis first stage Infection internal consistency Patient physiological psychometric properties psychometric property Psychometrics Purposive sampling questionnaire reliability Result selected stages subject Treatment Validity was measured [DOI] 10.1186/s12955-022-01922-0 PMC 바로가기 [Article Type] Research
Differential COVID-19 Symptoms Given Pandemic Locations, Time, and Comorbidities During the Early PandemicMedicine Published on 2022-01-282022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] Analysis analyzed approach article Better bioinformatics caused change China Clinical data clinical phenotype Comorbidities Comorbidity Coronavirus Infectious Disease Ontology (CIDO) cough country COVID COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 symptoms diabete diagnosed with COVID-19 diarrhea early pandemic Europe Factor feature Fever group hidden Hierarchical Human Human Phenotype Ontology (HPO) Hypothesis identify Italy kidney knowledge Loss of Smell loss of taste Occurrence Ontology outcomes pandemic Pandemics Patient Perspective phenotype positively correlated provide public health Region Research Result severity specific symptom spiral Stage stages Symptom the disease the patient time unique Vaccine viral variant widespread [DOI] 10.3389/fmed.2022.770031 PMC 바로가기 [Article Type] Medicine
Integrated Analysis Reveals the Characteristics and Effects of SARS-CoV-2 Maternal–Fetal TransmissionMicrobiology Published on 2022-01-272022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Affect affected Analysis Angiotensin-converting enzyme binding biological processe Care caused cells Characteristics CMV co-expressed conducted coronavirus coronavirus disease COVID-19 developmental Effect embryonic ENhance expressed expression level Factor fetal fetal development Health healthy high risk higher risk Infection Integrated analysis intestine key factor lung maternal–fetal transmission molecular mechanism much higher pandemic pathogen pathway physical barrier Placenta prenatally Prevent Probability provide receptor reported risk SARS-CoV-2 SARS-COV-2 infection sequencing data single-cell Spread stages T-cell activation tissue tissues TMPRSS2 Transcriptome transmembrane serine protease Transmission transmission rate virus infection Zika virus ZIKV [DOI] 10.3389/fmicb.2022.813187 PMC 바로가기 [Article Type] Microbiology
Studying the clinical, radiological, histological, microbiological, and immunological evolution during the different COVID-19 disease stages using minimal invasive autopsy최소 침습성 부검을 사용하여 상이한 COVID-19 질병 단계 동안 임상, 방사선 학적, 조직 학적, 미생물 학적 및 면역 학적 진화 연구Clinical Trial Published on 2022-01-252022-09-01 Journal: Scientific Reports [Category] 임상, 진단, 치료법, [키워드] alveolar damage America Autopsy change Characteristics clinical microbiology Cohort COVID-19 COVID-19 disease COVID-19 patients diffuse Diffuse alveolar damage disease evaluated Evolution had no heart histological histopathological IgG immunological immunological characteristics Immunopathogenesis Infection Inflammation interferon interferon-γ invasive liver organ Other other organs Pathogenesis pathophysiological mechanism pathophysiological mechanisms Patient PCR-confirmed COVID-19 patient positive radiological Significant significant differences significantly higher Society Stage stages Treatment viral infection WHO with COVID-19 [DOI] 10.1038/s41598-022-05186-y PMC 바로가기 [Article Type] Clinical Trial