Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PL proFull Paper Published on 2021-11-232022-10-31 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID-19, SARS, [키워드] ACE2 receptor acute respiratory syndrome addition Antiviral Antiviral agents Antiviral effect antiviral therapeutics approved complex complexes Compound compound screening coronavirus drug design Drug discovery evaluated Evidence gold, metallodrugs infected cell inhibitor Interaction ligands mechanisms metal NHC PLpro polyoxometalates potent Profiling protease Protein Replication SARS-CoV-2 SARS‐CoV‐2 selected silver Spike protein Spread starting point target tested the spike protein titanocene [DOI] 10.1002/chem.202103258 PMC 바로가기 [Article Type] Full Paper
The Role of Health Literacy among Outpatient Caregivers during the COVID-19 PandemicArticle Published on 2021-11-092022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] Ambulatory care Analysis association Caregiver collected conditions coronavirus COVID-19 COVID-19 pandemic cross-sectional dissemination equipment examined Health health behaviour healthy information information sufficiency literacy majority measure nutrition ordinal logistic regression Outpatient Outpatient Care pandemic parameter Perceived stress physical activity physically provided reduce reported representing Research role starting point Stress worries [DOI] 10.3390/ijerph182211743 PMC 바로가기 [Article Type] Article
Mental Health Needs Assessment During the COVID-19 Pandemic: Consensus Based on Delphi StudyPublic Health Published on 2021-10-202022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] Action activities activity addressed arising assessment conducted Consensus COVID-19 COVID-19 pandemic DelPhi epidemiological groups Health health plan implementation identify individuals initial International Local majority measure Measures mental health mental health services Needs Assessment pandemic plan Practitioner Program Psychological reached recognize recommendation Research response starting point [DOI] 10.3389/fpubh.2021.732539 PMC 바로가기 [Article Type] Public Health
Brief Research Report: Veterinary Student Perspective on COVID-19 and Veterinary MedicineVeterinary Science Published on 2021-10-142022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] adaptation affected coding content analysis Course COVID-19 COVID-19 pandemic Guidance help Impact impacts IMPROVE insight Medicine one health outcomes pathway Perspective positive public health Research response significant effect starting point student veterinary medicine veterinary student [DOI] 10.3389/fvets.2021.723890 PMC 바로가기 [Article Type] Veterinary Science
l -Arginine Improves Solubility and ANTI SARS-CoV-2 Mpro Activity of Rutin but Not the Antiviral Activity in Cellsl-아르기닌은 루틴의 용해도 및 ANTI SARS-CoV-2 Mpro 활성을 개선하지만 세포의 항바이러스 활성은 개선하지 않습니다Article Published on 2021-10-072022-09-10 Journal: Molecules [Category] SARS, 신약개발, 치료제, [키워드] l-arginine activity anti-SARS-CoV-2 arginine cellular COVID-19 pandemic drug in silico inhibitor main protease mixture outbreak pharmaceutical preparations pharmacokinetic pharmacological quercetin rutin SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 Mpro solubility starting point Test water [DOI] 10.3390/molecules26196062 PMC 바로가기 [Article Type] Article
Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16 †Chemistry Published on 2021-10-062022-10-29 Journal: RSC Chemical Biology [Category] COVID-19, [키워드] activities affinity analogue applied binding complex conserved Coronavirus infections develop drug drug design enzyme exhibiting experiment Health identification identify increasingly inhibit Interaction Intervention less Ligand methyltransferase nsp14 Proofreading Protein Replication reveal RNA SARS-CoV-2 Small molecules starting point Vaccine viral replication were used X-ray crystallography [DOI] 10.1039/d1cb00135c PMC 바로가기 [Article Type] Chemistry
Fragment-based in silico design of SARS-CoV-2 main protease inhibitorsSARS-CoV-2 주요 프로테아제 억제제의 단편 기반 in silico 설계Article Published on 2021-10-012022-09-11 Journal: Chemical biology & drug design [Category] SARS, 신약개발, 치료제, [키워드] 3CLpro approach AutoDock AutoDock vina binding binding affinity binding mode binding pocket co-crystallized Compound conformation conformations coronavirus Coronavirus COVID-19 crystal structure domain Drug discovery eight fragment fragment-based drug discovery generate Glide in silico inhibitor interactions linear combination linker main protease Mpro 3CLpro MD simulation MPro multivalency. Precision protease Protein Data Bank provided SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 replication screened selected small molecule Small molecules starting point Structure structures suggested therapeutic strategy were used X-ray X-ray crystal structure [DOI] 10.1111/cbdd.13914 PMC 바로가기 [Article Type] Article
Teamworking in Healthcare during the COVID-19 Pandemic: A Mixed-Method StudyArticle Published on 2021-10-012022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] analysed Burnout collected collective leadership contribute contributing to COVID-19 COVID-19 pandemic cross-sectional demonstrated driving examined Factor form Future healthcare hypothesised Ireland Longitudinal data media Mixed methods offer organisational citizenship pandemic participant platform Predictive Psychological psychological safety qualitative data response starting point statistical strained survey Teamwork variable widespread Work engagement [DOI] 10.3390/ijerph181910371 PMC 바로가기 [Article Type] Article
Mitigating Long-Term COVID-19 Consequences on Brain HealthNeurology Published on 2021-09-272022-11-01 Journal: Frontiers in Neurology [Category] COVID-19, [키워드] accelerated Brain brain inflammation changes in clinically Cognition cognitive comparison consequence coronavirus COVID-19 described Evidence Guidance Health immunological impacts include increasingly Injury mental health Moral injury nervous system neuromodulation neuroplasticity pandemic Resilience resulting risk factor SARS-CoV-2 significantly starting point syndrome [DOI] 10.3389/fneur.2021.630986 PMC 바로가기 [Article Type] Neurology
Computationally repurposed drugs and natural products against RNA dependent RNA polymerase as potential COVID-19 therapiesResearch Published on 2021-09-202022-10-30 Journal: Molecular Biomedicine [Category] COVID-19, [키워드] anticancer antiviral drugs Antiviral effect applied approach AutoDock vina binding energy calculate Compound COVID-19 drug drug candidate Drug repurposing identify in vitro in vivo infected patients inhibitor molecular docking molecular dynamics Molecular dynamics simulation other coronaviruses potential therapy proportion RdRP receptor reported Repurposed drug repurposing RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp shown starting point supplementary material tested the SARS-CoV-2 therapy treating COVID-19 Trial tyrosine utility Virtual screening [DOI] 10.1186/s43556-021-00050-3 PMC 바로가기 [Article Type] Research