Detection of SARS-CoV-2 Derived Small RNAs and Changes in Circulating Small RNAs Associated with COVID-19SARS-COV-2 유도 된 작은 RNA의 검출 및 COVID-19와 관련된 순환 소형 RNA의 변화Brief Report Published on 2021-08-112022-09-10 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] Ageusia Analysis candidate gene change circulating circulating-miRNA cleavage conserved convalescent COVID-19 patient COVID COVID-19 cytokine Cytokine storm Defense defense mechanism described detectable detection double-stranded RNA events homologous Host host defense human miRNA human miRNAs immune response immune responses Jak-STAT Long COVID mechanism Mild miRNA miRNAs NSP2 nsp4 plasma plasma sample plasma samples product reduced RNA sequence RNAs SARS-CoV-2 sequence Sequencing severe cases severe COVID-19 siRNA small RNA Small RNAs STAT Symptoms the disease transcriptional gene silencing Trigger triggers Viral viral infection virus with COVID-19 [DOI] 10.3390/v13081593 PMC 바로가기 [Article Type] Brief Report
The Many Faces of JAKs and STATs Within the COVID-19 StormImmunology Published on 2021-07-132022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, SARS, [키워드] “cytokine storm” Activation activator Cell consequence coronavirus 2 COVID-19 CoVs cytokine cytokine receptor Cytokine release syndrome Cytokine storm downstream Effect elevated face global pandemic Health immunologically Jak JAK inhibitor JAK-STAT pathway janus kinase positive-sense Protein respiratory resulting RNA virus SARS-CoV-2 signal Signaling STAT storm the SARS-CoV-2 transducer triggered [DOI] 10.3389/fimmu.2021.690477 PMC 바로가기 [Article Type] Immunology
Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity선천 면역 자극을 통한 시험관 내 SARS-CoV-2 복제에 대한 인플루엔자 A 바이러스 결함 간섭 입자의 항바이러스 활성Communication Published on 2021-07-112022-09-11 Journal: Cells [Category] SARS, 변종, 치료제, [키워드] abrogation activity acute respiratory syndrome acute respiratory syndrome coronavirus Administered Antiviral antiviral activity antiviral agent Antiviral treatment applicability approved Cell Cell culture Co-infection Complete conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 defective interfering particles dependent on DI244 DIP disease effective Efficacy experiment human lung cells IAV Immune escape in vitro Influenza influenza A influenza A virus inhibitory effect Innate Innate immunity interferon JAK/STAT janus Janus kinase leads OP7 pandemic Particle Replication respiratory Respiratory virus infections SARS-CoV-2 SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signaling STAT Stimulation Transcription Treatment treatment of COVID-19 Vaccine vaccine availability variant variants of SARS-CoV-2 virus virus infections [DOI] 10.3390/cells10071756 PMC 바로가기 [Article Type] Communication
Interferons in Systemic Lupus ErythematosusArticle Published on 2021-06-232024-09-04 Journal: Rheumatic diseases clinics of North America [Category] 대상포진, [키워드] interferon Jak Lupus STAT [DOI] 10.1016/j.rdc.2021.04.001 PMC 바로가기 [Article Type] Article
Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy과립구 대식세포 집락 자극 인자가 도래했다: 백신 보조제에서 항바이러스 면역요법까지Review Published on 2021-06-012022-09-11 Journal: Cytokine & growth factor reviews [Category] SARS, 치료제, [키워드] activate activated activated T cells adjuvant alveolar alveolar macrophage Antiviral antiviral action attribute cascades clinical trial COVID-19 Cytokines defend GM-CSF growth factor help IFN IFNs Immune cell immune cells immune response Immunotherapy infections Inflammation Innate immunity JAK/STAT knowledge Lungs Macrophage macrophage differentiation macrophages MAPK NFκB pathway Pathways PI3K pro-inflammatory cytokine pro-inflammatory cytokines produced Protein reduce respiratory infection respiratory infections STAT T cells Vaccine virus [DOI] 10.1016/j.cytogfr.2021.01.001 PMC 바로가기 [Article Type] Review
JAK-STAT Pathway Inhibition and their Implications in COVID-19 TherapyJAK-STAT 경로 억제 및 COVID-19 치료에 미치는 영향Review Published on 2021-06-012022-09-11 Journal: Postgraduate medicine [Category] 유전자 메커니즘, 치료법, [키워드] 3CL pro activated Activation adverse effects B cell Baricitinib clinical trial contrary COVID-19 COVID-19 patients COVID-19 therapy cytokine cytokine receptor cytokine signaling Cytokine storm dendritic cell dendritic cells determine Disease progression disease severity Efficacy effort endothelial cells envelope protein envelope proteins excessive inflammation Host hosts immune response immune responses implicated incidence of COVID-19 increase Inflammation Inflammatory marker inflammatory markers Inflammatory mediators inhibition inhibitor inhibitors Jak Jak-STAT JAK/STAT JAK/STAT pathway JAK/STAT signaling janus Janus kinase Lymphocytes macrophages mechanism membrane molecular Monocytes natural killer cell Natural killer cells nucleocapsid nucleus Phosphorylation Pneumocytes progression promote protease Proteases Protein recruitment reduce Regulatory Authorities regulatory authority required ruxolitinib SARS-CoV-2 SARS-COV-2 infection severity signaling cascade signaling cascades STAT STATs structural protein structural proteins supported suppressor suppressors survival T cell the disease Therapeutic strategies therapeutic strategy Tofacitinib translate Trigger tyrosine [DOI] 10.1080/00325481.2020.1855921 PMC 바로가기 [Article Type] Review
Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies?Review Published on 2021-05-262024-09-02 Journal: Cancers [Category] 대상포진, [키워드] Jak JAK inhibitor leukemia NK cells STAT T cells [DOI] 10.3390/cancers13112611 PMC 바로가기 [Article Type] Review
Compassionate use of ruxolitinib in patients with SARS-Cov-2 infection not on mechanical ventilation: Short-term effects on inflammation and ventilation기계적 환기가 아닌 SARS-Cov-2 감염 환자에서 룩소리티닙의 동정적 사용: 염증 및 환기에 대한 단기 영향Article Published on 2021-05-012022-09-11 Journal: Clinical and translational science [Category] SARS, 신약개발, [키워드] accompany affected Anti-inflammatory anti-inflammatory drug anti-inflammatory effect Antiviral appear approach baseline benefit Biomarkers biomarkers of inflammation C-reactive protein C-reactive protein (CRP Chain Reaction clinical pharmacology clinical response collected compassionate use compassionate-use contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection criteria CRP Cytokines during treatment Dyspnea Effect effective Evidence hyperinflammation Hypothesis immune cells inclusion criteria Infection Inflammation Inflammatory response inhibit interferons interstitial pneumonia invasive ventilation JAK inhibitor jak inhibitors Jak-STAT janus Janus kinase less Lungs management mechanical ventilation mmHg need for oxygen oxygen oxygen saturation oxygen support PaO pathway Patient patients hospitalized patients with SARS-CoV-2 polymerase chain polymerase chain reaction positive present pro-inflammatory pro-inflammatory cytokines prognostic progression provided reduce reduced reduction reinforcement respiratory Respiratory function ruxolitinib SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome Side effect significantly more STAT Support Symptom systemic inflammation target the disease therapeutic therapeutic agent therapeutic agents Topic Treatment type I interferon type I interferons Ventilation were recorded [DOI] 10.1111/cts.12971 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis InsightsSARS-CoV-2 감염은 JAK 길항 작용에 의한 건선성 관절염 발적 및 유착 상주 형질세포양 수지상 세포 유형-1 인터페론 억제를 유도하여 새로운 척추관절염 발병 통찰력 제공Immunology Published on 2021-04-152022-09-11 Journal: Frontiers in Immunology [Category] MERS, 유전자 메커니즘, [키워드] activated Activation antagonism Arthritis arthropathy Blood CD45 CD45+ cells characterized COVID-19 COVID-19 infection CpG DEGs dendritic dendritic cell dendritic cells differentially expressed gene Elevation enthesis evaluate evaluated flare Gene Expression IFNα imiquimod Infection inhibition insight interferon Interferon alpha interferon response investigated Jak JAK/STAT signaling pathway maturation mechanism microbe microbes modulation NF-κB NF-κB signaling normal novel objective occurred Pathway analysis pDC pDCs plasmacytoid dendritic cell plasmacytoid dendritic cells Protein psoriatic arthritis resident Result RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 SARS-CoV2 infection Signaling significantly spondyloarthritis STAT stimulated suppressed therapeutic TLR-7 TNF Tofacitinib Toll-like receptor toll-like receptor signaling Trigger triggered triggers upregulated Viral viral infection was performed [DOI] 10.3389/fimmu.2021.635018 PMC 바로가기 [Article Type] Immunology
Network Meta-Analysis on the Mechanisms Underlying Alcohol Augmentation of COVID-19 PathologiesCOVID-19 병리의 알코올 증강의 기본 메커니즘에 대한 네트워크 메타 분석Meta-Analysis Published on 2021-04-012022-08-31 Journal: Alcoholism, clinical and experimental research [Category] MERS, meta-analysis, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected alcohol alcohol consumption Analysis anti-inflammatory mediator anti-inflammatory mediators augmentation base bioRxiv caused cellular metabolism changes in clinician conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients cytokine Cytokines dataset early phase Effect ENhance Ethanol EtOH Fever fibrosis Gene Expression gene expression profile GEO GEO database glucocorticoid Glucocorticoid receptor hepatic fibrosis HMGB1 homeostasis hyperinflammatory phase IL-1 IL-1β IL-6 IL-6 signaling pathways Inflammation Inflammatory mediators Ingenuity Pathway Analysis Ingenuity Pathway Analysis. inhibiting IPA JUN knowledge base lung mapped mediators Meta-analysis metabolism molecule molecules network Network meta-analysis Neuroinflammation pandemic Pathologies pathway Pathways Patient predicted receptor respiratory retrieved risk RNA-sequencing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteins sequencing data severe acute respiratory syndrome Coronavirus signaling pathway STAT systemic inflammation TNF transcription factors Viral viral infections worldwide crisis [DOI] 10.1111/acer.14573 PMC 바로가기 [Article Type] Meta-Analysis