cGAS-STING Signaling Pathway and Liver Disease: From Basic Research to Clinical PracticeReview Published on 2021-08-182023-08-30 Journal: Frontiers in Pharmacology [Category] E형 간염, [키워드] Cancer cGAS Inflammation liver STING [DOI] 10.3389/fphar.2021.719644 PMC 바로가기 [Article Type] Review
cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophagesResearch Article Published on 2021-08-042023-08-30 Journal: Gut Microbes [Category] E형 간염, [키워드] cGAS ISGs murine norovirus RIG-I STING [DOI] 10.1080/19490976.2021.1959839 PMC 바로가기 [Article Type] Research Article
HBsAg Dampened STING Associated Activation of NK Cells in HBeAg-Negative CHB PatientsArticle Published on 2021-07-162023-06-03 Journal: International Journal of Molecular Sciences [Category] B형 간염, [키워드] CHB NK cells STAT3 STING [DOI] 10.3390/ijms22147643 PMC 바로가기 [Article Type] Article
Inflammatory cytokine storms severity may be fueled by interactions of micronuclei and RNA viruses such as COVID-19 virus SARS-CoV-2. A hypothesis염증성 사이토카인 폭풍의 심각성은 COVID-19 바이러스 SARS-CoV-2와 같은 RNA 바이러스와 소핵의 상호 작용에 의해 촉진될 수 있습니다. 가설Review Published on 2021-07-012022-09-11 Journal: Mutation research. Reviews in mutation research [Category] SARS, 변종, 유전자 메커니즘, [키워드] affected Aneuploidy Cell cGAS cGAS-STING. chromosomal instability COVID-19 COVID-19 virus cyclic GMP cytokine production Cytokine storm Effect elevated Evidence Factor Frequency high risk Hypothesis immune response immunologically increase individual induce Infection Inflammation Inflammatory cytokine inflammatory cytokine production Interaction interferon leakage lymphocyte mechanism Micronuclei moderate observation pro-inflammatory cytokine pro-inflammatory response reduction RNA RNA virus RNA viruses SARS-CoV-2 SASP secretory senescence Senescence Associated Secretory Phenotype severity stimulator STING susceptible threshold tissue damage virus infection viruses weakened [DOI] 10.1016/j.mrrev.2021.108395 PMC 바로가기 [Article Type] Review
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus InfectionSTING 신호 전달 경로의 활성화는 인간 코로나바이러스 감염을 효과적으로 차단합니다Article Published on 2021-05-242022-09-11 Journal: Journal of Virology [Category] SARS, 변종, [키워드] Activation addition Antiviral antiviral therapeutics antiviral therapy block coronavirus Coronavirus infection coronavirus strain COVID-19 COVID-19 pandemic Defense develop downstream effective examined greater HCoV HCoV-OC43 Health highlight Host host defense Human human coronavirus human coronavirus OC43 identify IFNs Infection inhibit innate immune interferons IRF3 mutated variants novel OC43 Other other coronaviruses Outbreaks pathogenic coronavirus pathogenic coronaviruses pathway Pathways potential therapeutic target public health SARS-CoV-2 SARS-COV-2 infection Signaling signaling pathway Spread stimulate STING type I interferon type I interferons [DOI] 10.1128/JVI.00490-21 PMC 바로가기 [Article Type] Article
A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection디아미도벤즈이미다졸 STING 작용제는 SARS-CoV-2 감염으로부터 보호합니다Research Articles Published on 2021-05-182022-09-10 Journal: Science Immunology [Category] Fulltext, SARS, 진단, 치료제, [키워드] activate Activation animals Antiviral antiviral therapeutics Cell chronic disease Complete coronavirus COVID-19 cytokine Defense effective epithelial cells family global pandemic Human infected with SARS-CoV-2 inhibited intranasally Lower respiratory tract lung Lung epithelial cells lymphocyte mice morbidity and mortality prevention of COVID-19 Proinflammatory cytokine PROTECT respiratory Respiratory disease RNA virus RNA viruses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe respiratory disease short-lived STING Support therapy Treatment upper and lower respiratory tract Vaccine Viral viral replication virus infection viruses [DOI] 10.1126/sciimmunol.abi9002 PMC 바로가기 [Article Type] Research Articles
Inhibition of coronavirus infection by a synthetic STING agonist in primary human airway system1차 인간 기도 시스템에서 합성 STING 효능제에 의한 코로나바이러스 감염 억제Article Published on 2021-03-012022-09-11 Journal: Antiviral Research [Category] SARS, 유전자 메커니즘, 치료제, [키워드] 229E Activation addition agonists Air-liquid interface airway anti-coronavirus activity antiviral activity apical surface approved autophagy caused cell culture systems clinically common cold coronavirus Coronavirus infection Coronavirus infections COVID-19 cultures Defense defense mechanisms demonstrated dependent on diABZI. dimeric effective elicit epithelial fibroblast HCoV HCoV-229E highly pathogenic Host host defense human coronavirus human coronavirus 229E human coronaviruses Infection inhibition inhibitory effect initiated interferon interferon pathway International investigated low-dose lung cell mechanism Medicine microbial microbial infections other coronavirus other coronaviruses outbreak Pathogens pathway Pneumonia Prevent prevented primary human airway public health emergency receptor reduced Remdesivir responses SARS-CoV-2 SARS-CoV-2 viral load SARS-CoV-2 virus small molecule Spread stimulator STING STING agonist the interferon the SARS-CoV-2 therapeutic potential treat Treatment triggered type I interferon unmet need Viral load [DOI] 10.1016/j.antiviral.2021.105015 PMC 바로가기 [Article Type] Article
Detection of Viral Infections by Innate ImmunityReview Published on 2021-01-012023-07-11 Journal: Biochemical pharmacology [Category] SARS, [키워드] cGAS. COVID-19 DNA sensors IFI16 inflammasomes Innate immunity interferon Pattern recognition receptors pro-inflammatory cytokines RIG-like receptors SARS-CoV-2 STING Toll-like receptors virus [DOI] 10.1016/j.bcp.2020.114316 [Article Type] Review
Spatial and temporal roles of SARS-CoV PL pro -A snapshotSARS-CoV PL pro -A 스냅샷의 공간적 및 시간적 역할Review Published on 2021-01-012022-09-11 Journal: FASEB journal : official publication of the Federa [Category] 치료법, [키워드] 3CL pro accessory protein accessory proteins Antiviral appear autocleavage C-terminus can not cleave cleaved CoV replication cysteine cysteine protease dilemma domain E3 ubiquitin ligase envelope Factor inhibit inhibitor innate immune response Interaction interferon interferon-stimulated gene ISG15 its target protein its target proteins IκBα membrane motif NF-κB nonstructural protein nsp1 Nsp3 Nsps Nucleocapsid proteins p53 Papain Papain-like protease PLPro polyprotein polyproteins pp1a pp1ab promote protease Protein provide RCHY1 released Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 infections stimulator STING TNF ubiquitin unique Viral Zinc [DOI] 10.1096/fj.202002271 PMC 바로가기 [Article Type] Review
Lymphocyte Changes in Severe COVID-19: Delayed Over-Activation of STING?심각한 COVID-19의 림프구 변화: STING의 지연된 과활성화?Review Published on 2020-12-012022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] ACE2 activated Activation acute respiratory syndrome affected antigen presenting cell antigen presenting cells Aspirin autophagy B cell B cell response B cells CD147 CD26 CD4+ CD8+ CD8+ T cell cGAMP cGAS change contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyclic cytokine cytokine secretion damages Delayed dinucleotide DNA DNA damage early stages Express expressed functional Gain of function Genes Host Human IL-6 immune cells induce infancy Infection inhibit inhibitor interferon IRF3 Last less lymphocyte Lymphocytes lymphopenia main receptor microbial NF-κB pathway Pneumonitis Recognition respiratory responsiveness SARS-CoV-2 severe coronavirus disease severe COVID-19 severe COVID-19 patient severe COVID-19 patients similarity SLC19A1 small molecule Small molecules stimulator STING T and B cell responses T cell T cells TBK1 TCR Th2 transfer triggered Vasculopathy [DOI] 10.3389/fimmu.2020.607069 PMC 바로가기 [Article Type] Review