Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease중증 급성 호흡기 증후군 코로나바이러스-2 3C 유사 프로테아제의 강력한 스피로사이클릭 억제제의 구조 유도 설계Article Published on 2022-06-092022-09-11 Journal: Journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CL pro binding COVID-19 pandemic determinant direct-acting antiviral Direct-acting antivirals element High-resolution Host imperative in viral inhibitor inhibitors inhibitors of SARS-CoV-2 mechanism mechanism of action MERS-CoV potency potent protease public health Replication respiratory SARS-CoV-2 structures targets viral replication [DOI] 10.1021/acs.jmedchem.2c00224 PMC 바로가기 [Article Type] Article
Structural Plasticity and Immune Evasion of SARS-CoV-2 Spike VariantsSARS-CoV-2 스파이크 변이체의 구조적 가소성 및 면역 회피Review Published on 2022-06-092022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] accumulated mutation accumulated mutations acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected affecting antibody antibody escape approach atomic binding Care caused cells conformations coronavirus COVID-19 COVID-19 pandemic functions global pandemic Health Health care Health care system Host immune immune evasion Infection Interpretation Limited molecular molecular mechanism mutations parental profiles protective vaccines Protein recent finding recent findings resolved S protein S variant SARS-CoV-2 SARS-CoV-2 variants scientist severe acute respiratory syndrome Coronavirus shifting significantly spike Spike proteins Structure structures therapeutic option Transmissibility Vaccines variants variants of concern virus entry virus transmissibility Virus-host interaction Virus-host interactions VoC VOCs Wuhan-Hu-1 [DOI] 10.3390/v14061255 PMC 바로가기 [Article Type] Review
Development of Metal Complexes for Treatment of Coronaviruses코로나바이러스 치료를 위한 금속 착체 개발Article Published on 2022-06-082022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] advent analyzed antibody antiviral therapies binding affinity Complete complex complexes contradiction coronavirus coronavirus disease coronavirus variants country COVID-19 Critical death described determine development disease docking effective Epidemic Infection lockdown mechanism metal metal complexes New coronavirus pandemic PDB pharmacokinetics pharmacophore pharmacophore. Prevent promise protease Protein Protein Data Bank RCSB pdb (Protein Data Bank) database related disease required Research SARS-CoV-2 Spread Structure structures suggested Toxicity transfer Treatment Vaccine variants virus [DOI] 10.3390/ijms23126418 PMC 바로가기 [Article Type] Article
New insights into the catalytic mechanism of the SARS-CoV-2 main protease: an ONIOM QM/MM approachSARS-CoV-2 주요 프로테아제의 촉매 메커니즘에 대한 새로운 통찰력: ONIOM QM/MM 접근법Article Published on 2022-06-012022-09-11 Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral drug target approach calculated catalysis catalytic Catalytic mechanism characterized COVID-19 COVID-19 pandemic described drug design enzyme free energy Gibbs free energy hydrolysis inhibitor involved kinetic data M pro main protease mechanism methodology New protease QM/MM reactant Replication residues SARS-CoV-2 SARS-CoV-2 virus Structure structures the SARS-CoV-2 the SARS-CoV-2 virus thioester treated virus [DOI] 10.1007/s11030-021-10259-7 PMC 바로가기 [Article Type] Article
Assessment of the optic nerve, macular, and retinal vascular effects of COVID-19Research article Published on 2022-06-012022-10-05 Journal: Canadian journal of ophthalmology. Journal canadie [Category] 바이오마커, 진단, [키워드] abnormality Analysis assessment Asymptomatic COVID-19 average Biomarker complex conducted control group COVID-19 COVID-19 group COVID-19 symptom cross-sectional Diagnostic method domain evaluate the effect Foveal avascular zone ganglion cell healthy control infection with SARS-CoV-2 neurologic Neurovascular objective Optical coherence tomography participant Patient peripapillary quantified recovering from COVID-19 Region Result retinopathy SARS-COV-2 infection significantly structures subject symptomatic symptoms of COVID-19 Vascular vascular effect vessel were measured [DOI] 10.1016/j.jcjo.2022.06.016 [Article Type] Research article
Economic Impact of COVID-19 Pandemic on Dental Practices in Germany: A Cross-Sectional SurveyObservational Study Published on 2022-05-282022-10-04 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 임상, [키워드] Administered affected Analysis anonymously association automated average calibrated carried Corona virus COVID-19 COVID-19 pandemic cross-sectional survey dental dental practice dentist dentistry difference economic effects evaluate evaluated Fisher exact test Germany global pandemic global pandemic. help Impact increase in information less Linear regression analysis measure medium pandemic Pandemics positive Practice proportion quarantine questionnaire respondent Seven structures survey was performed [DOI] 10.3390/ijerph19116593 PMC 바로가기 [Article Type] Observational Study
Structural basis of nanobodies neutralizing SARS-CoV-2 variantsSARS-CoV-2 변이체를 중화시키는 나노바디의 구조적 기초Article Published on 2022-05-052022-09-11 Journal: Structure (London, England : 1993) [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 ACE2 receptor antibody bi-paratopic nanobodies binding site block complex conserved contribute coronavirus coronavirus epidemics crystal structure domain epitope immunized inhibit nanobody neutralization potency Neutralizing neutralizing antibody other coronavirus overlap Pandemics RBD Receptor-binding domain resolved SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2 virus significantly Spike protein Structure structures target the spike protein variants of SARS-CoV-2 Viral viral escape virus X-ray crystallography [DOI] 10.1016/j.str.2022.02.011 PMC 바로가기 [Article Type] Article
Structures of Omicron spike complexes and implications for neutralizing antibody developmentOmicron 스파이크 복합체의 구조 및 중화 항체 개발에 대한 의미Article Published on 2022-05-032022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 antibodies antibody Antibody binding Antibody structure binding biochemical complexes country CP: Immunology CP: Microbiology cryo Cryo-electron microscopy cryo-EM cryo-EM structures Delta dominant drugs electron microscopy Evidence explain Fab immune immune evasion immunology implication information interactions lead Microbiology Mutation mutations neutralization Neutralization antibody neutralization assays neutralizing antibody omicron provide required responsible SARS-CoV-2 spike spike mutation spike mutations Structure structures the SARS-CoV-2 therapeutic therapeutic antibodies Vaccine variant wild-type [DOI] 10.1016/j.celrep.2022.110770 PMC 바로가기 [Article Type] Article
Repurposing dyphylline as a pan-coronavirus antiviral therapy범 코로나 바이러스 항 바이러스 요법으로 디필린 용도 변경Article Published on 2022-05-012022-09-11 Journal: Future Medicinal Chemistry [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] Alpha Antiviral antiviral agent antiviral therapy bind catalytic dyad Cell culture coronavirus COVID-19 pandemic CoVs Cystine Drug discovery dyphylline FDA-approved drug functional enzyme functional enzymes HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoVs highly pathogenic histidine Human human coronavirus human coronaviruses human coronaviruses (HCoVs) humans inhibited life cycle Mild MPro NL63 OC43 protease repurposing respiratory diseases SARS-CoV-2 severe respiratory disease severe respiratory diseases structures Support targets therapeutically target viral replication Virtual screening virus Virus life cycle viruses xanthine zoonotic [DOI] 10.4155/fmc-2021-0311 PMC 바로가기 [Article Type] Article
Cell surface detection of vimentin, ACE2 and SARS-CoV-2 Spike proteins reveals selective colocalization at primary ciliavimentin, ACE2 및 SARS-CoV-2 스파이크 단백질의 세포 표면 검출은 일차 섬모에서 선택적 공동 국소화를 나타냅니다Article Published on 2022-04-292022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acetylated tubulin Arl13b binding Cell cell surface cell types cells cellular receptor cellular receptors ciliated cytoplasm docking Extracellular facilitate filament protein immunoreactivity Incubation Interaction Intermediate filament marker moderate occur Particle plasma membrane platform positive Protein receptor reported reveal S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein selective spike Spike protein Spike proteins structures tubulin vimentin viral invasion virus [DOI] 10.1038/s41598-022-11248-y PMC 바로가기 [Article Type] Article