suppresse – Page 4 – Communicable Diseases Research

Metformin Suppresses Monocyte Immunometabolic Activation by SARS-CoV-2 Spike Protein Subunit 1

Immunology

Published on 2021-11-112022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

Proximity-dependent biotinylation detects associations between SARS coronavirus nonstructural protein 1 and stress granule–associated proteins

근접 의존성 비오틴화는 SARS 코로나바이러스 비구조 단백질 1과 스트레스 과립 관련 단백질 사이의 연관성을 감지합니다

Research Article

Published on 2021-11-112022-09-10
Journal: The Journal of Biological Chemistry [Category] MERS, SARS, 유전자 메커니즘, 치료기술,

[키워드] α-CoV, α-coronavirus β-CoV, β-coronavirus acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Amino acid amino acids Analysis assembly association BioID2 biotinylated biotinylated proteins BSA, bovine serum albumin C-terminal cellular coronavirus Critical detect disrupt eIF, eukaryotic translation initiation factor Exosome Factor FDR, false discovery rate followed by G3BP1 G3BP1, Ras GTPase-activating protein SH3 domain–binding protein 1 HA, hemagglutinin HEK293, human embryonic kidney 293 cell line Host host cell host gene expression identify interact Interaction maturation mechanism MERS-CoV, Middle Eastern respiratory syndrome coronavirus mRNAs Mutation nonstructural protein 1 nsp1 nsp1, nonstructural protein 1 observé pre-mRNA Protein Proteins proteomic respiratory ribosome SARS Coronavirus SARS-CoV SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoV, severe acute respiratory syndrome coronavirus severe acute respiratory syndrome Coronavirus SG, stress granule sodium sodium arsenite Stress stress granule suppresse Transcription Viral Viral protein
[DOI] 10.1016/j.jbc.2021.101399 PMC 바로가기 [Article Type] Research Article

Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction

헴 옥시게나제-1 유도를 통한 코로나19 치료의 새로운 후보인 헤민

Article

Published on 2021-11-022022-09-10
Journal: Scientific Reports [Category] MERS, SARS, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Antimicrobial therapy antiviral activity Antiviral effect antiviral effects Biliverdin byproduct causative agent cells coronavirus coronavirus disease Coronavirus disease-19 COVID-19 death rate effective enzyme expression expression vector Free growth heme hemin in vitro inducer Inflammatory response inhibit investigated iron oxidative stress Protein reduce reported respiratory restrict Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication selectivity index severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suggested suppresse suppressed therapeutic transient expression treating COVID-19 Treatment Viral viral infection viral infections virus
[DOI] 10.1038/s41598-021-01054-3 PMC 바로가기 [Article Type] Article

The Role of an Anti-Inflammatory Diet in Conjunction to COVID-19

Review

Published on 2021-10-292022-11-01
Journal: Diseases [Category] COVID-19,

Functional Effects of Cardiomyocyte Injury in COVID-19

COVID-19에서 심근세포 손상의 기능적 효과

Cellular Response to Infection

Published on 2021-10-202022-09-10
Journal: Journal of Virology [Category] MERS, 유전자 메커니즘,

[키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect Analysis Blood cardiac disease Cardiomyocytes Cell clinical Clinical data Clinical finding Clinical findings Comorbidities Comorbidity Computational biology contractile contractile apparatus coronavirus COVID-19 COVID-19 patient COVID-19 patients Culture decrease decreased expression develop disease disorganization dysfunction echocardiography Effect elevated Elevation expression Extracellular healthy heart heart disease heart tissue hearts hospitalized patient hospitalized patients identify IL-1β IL-10 IL-1β IL-6 increase infect Infection Injury interleukin Interleukins Laboratory machine learning mechanism Mount Sinai Mount Sinai Health System mRNA multinucleated cells multiple organs NL63 observation Patient physiological physiological change physiological effect physiological effects pluripotent stem cell Protein reduced respiratory resulting SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus subject subset suppresse System Treatment Trigger triggers troponin troponin I underlie ventricular ventricular ejection Viral viral infection virus virus infection
[DOI] 10.1128/JVI.01063-21 PMC 바로가기 [Article Type] Cellular Response to Infection

Socioeconomic Status and COVID-19-Related Psychological Panic in China: The Role of Trust in Government and Authoritarian Personality

Article

Published on 2021-10-162022-10-29
Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS,

PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective Autophagy

Research Article

Published on 2021-10-062022-10-30
Journal: Microbiology Spectrum [Category] COVID-19,

[키워드] activate addition alphacoronavirus Antiviral antiviral response Antiviral strategies autolysosome autophagy coronavirus Coronaviruses CoV CoV replication CoVs cytoplasmic Degradation demonstrated develop Diseases drug E3 ubiquitin ligase eight Gene Expression help Host host protein Human IFN increase inhibit inhibiting interact isoform mRNA stability N protein nucleocapsid PABPC4 pathway Protein receptor recruited regulated Replication restriction factor resulting selective selective autophagy severe disease signaling pathway significantly SP1 suppresse the Coronaviridae the interferon the N protein Therapies These data transcription factor SP1 translation Vaccine viral infection viral proliferation viral replication virus
[DOI] 10.1128/Spectrum.00908-21 PMC 바로가기 [Article Type] Research Article

Coronavirus Nsp1: Immune Response Suppression and Protein Expression Inhibition

Microbiology

Published on 2021-09-282022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

Multi-level inhibition of coronavirus replication by chemical ER stress

Article

Published on 2021-09-202022-10-04
Journal: Nature Communications [Category] SARS, 치료제,

[키워드] Analysis Antiviral antiviral effects autophagic flux block bronchial epithelial cells cell type chaperone complexes component coronavirus Coronavirus replication counteract CoV replication CoVs Degradation derivative downregulation drugs ER stress Evidence Factor HCoV-229E HERPUD1 Host human pathogen IMPROVE inducer infected cell Infection inhibit inhibiting mechanism MERS-CoV modulate pathway Pathways pharmacological Protein proteome Quality control Replication required SARS-CoV-2 selective specific treatment suppress suppresse Systems virology translational UBA6 unfolded protein response viability viral infection Virus-host interactions ZNF622
[DOI] 10.1038/s41467-021-25551-1 PMC 바로가기 [Article Type] Article

Co-Spray Dried Nafamostat Mesylate with Lecithin and Mannitol as Respirable Microparticles for Targeted Pulmonary Delivery: Pharmacokinetics and Lung Distribution in Rats

Article

Published on 2021-09-192022-10-28
Journal: Pharmaceutics [Category] COVID-19,