Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signalingArticle Published on 2020-01-202022-11-01 Journal: Cell Death & Disease [Category] Coronavirus, MERS, [키워드] accelerated aminopeptidase N APN Cell contrary crypt cell decrease described diarrheal differentiation Disease model disrupt Enterocyte Factor gastroenteritis Goblet cell goblet cells greater homeostasis Hypothesis inactivation Infection inhibit intestinal intestinal stem cell Invasion mechanism mitochondrial mucin Notch occur Paneth cell Pathogenesis pathway promoted Protein provided receptor regulate Replication ROS secretion Self-renewal Signaling Stem-cell differentiation Stem-cell niche target TGEV therapeutic transmissible gastroenteritis virus virus virus infection [DOI] 10.1038/s41419-020-2233-6 PMC 바로가기 [Article Type] Article
Identification of a Novel Linear B-Cell Epitope on the Nucleocapsid Protein of Porcine DeltacoronavirusArticle Published on 2020-01-192022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, [키워드] Amino acid Analysis antibody Asian can be used conserved coronavirus diagnostics epitope FIVE highest binding affinity identification mAbs monoclonal monoclonal antibodies monoclonal antibody novel nucleocapsid PEDV Porcine deltacoronavirus Protein reactivity sequence similarity Strains Structural analysis synthetic peptide tested TGEV the N protein virus replication [DOI] 10.3390/ijms21020648 PMC 바로가기 [Article Type] Article
Prevalence and phylogenetic analysis of porcine diarrhea associated viruses in southern China from 2012 to 2018Research Article Published on 2019-12-272022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] acute diarrhea Analysis average caused China Chinese circulating Co-infection COE collected coronavirus CoV detection rate diarrhea diarrheal epidemic diarrhea epitope Evolution FIVE gastroenteritis Genetic Genotype IIa indicated Mutation occurred outbreak Outbreaks pathogenic PEDV Phylogenetic analysis Porcine deltacoronavirus Porcine diarrhea Porcine epidemic diarrhea virus Prevalence prevalence rate prevalent Prevent Region responsible Result South Korea spike gene strain Strains Swine acute diarrhea syndrome coronavirus syndrome tested TGEV USA variant virus [DOI] 10.1186/s12917-019-2212-2 PMC 바로가기 [Article Type] Research Article
Identification and analysis of long non-coding RNAs that are involved in inflammatory process in response to transmissible gastroenteritis virus infectionResearch Article Published on 2019-11-042022-10-28 Journal: BMC Genomics [Category] Coronavirus, [키워드] acting Acute inflammation Analysis binding biological process Cell cell line differentially expressed element epithelial expression of gene gastroenteritis Genes identification Infection Inflammation inflammation response inflammatory process Inflammatory response intestinal intestinal epithelial cell involved leukemia lncRNA lncRNA binding proteins lncRNAs Long long non-coding RNA Messenger RNA microRNA miRNA miRNAs mRNAs Necrosis Next-generation sequencing NGS NLRs NOD-like receptor noncoding RNA p65 Pathways Phosphorylation PML profile Protein Proteins reduction Result RIG-I-like receptor RLRs TGEV TLRs TNF Toll-like receptor transcription factor transmissible gastroenteritis virus virus infection was used [DOI] 10.1186/s12864-019-6156-5 PMC 바로가기 [Article Type] Research Article
Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virusArticle Published on 2019-09-122022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] aminopeptidase Analysis Antigen APN Biological techniques caused Cell Cloning Coronaviruses described disease Diseases economic loss embryonic lethal enteric disease epidemic diarrhea epithelial cell gastroenteritis host cell in vitro Infection lack lesion measure Mortality Neonatal normal pregnancy nuclear PEDV produced producing provide putative receptor reported small intestine small intestines susceptible target tissue TGEV thought transfer viability viral challenge virulent virus wildtype [DOI] 10.1038/s41598-019-49838-y PMC 바로가기 [Article Type] Article
Porcine transmissible gastroenteritis virus inhibits NF-κB activity via nonstructural protein 3 to evade host immune systemResearch Published on 2019-08-052022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] Activation amino acid residue analyzed canonical cause cells compose coronavirus Critical cytokine production Degradation demonstrated develop diarrhea domain dose-dependent inhibition downregulation enzyme activity evade exhibited family Coronaviridae gastroenteritis Host host immune system host innate immunity identify immunoprecipitation individual Infection inflammatory factors inhibit inhibiting inhibitory effect innate immune innate immune response involved IκBα modulating modulation mRNA expression NF-κB NF-κB NF-κB signaling non-structural protein nonstructural protein 3 Nsp3 nuclear nuclear translocation p65 Pathogenesis pathway Phosphorylation PLP PLP2 previous study Protein provide quantitative PCR reporter Result signaling pathway TGEV transmissible gastroenteritis virus ubiquitination Viral protein virus was used watery [DOI] 10.1186/s12985-019-1206-9 PMC 바로가기 [Article Type] Research
Circular RNA CircEZH2 Suppresses Transmissible Gastroenteritis Coronavirus-induced Opening of Mitochondrial Permeability Transition Pore via Targeting MiR-22 in IPEC-J2Research Paper Published on 2019-07-252022-10-29 Journal: International Journal of Biological Sciences [Category] Coronavirus, [키워드] activated Activation B cell caused Cell cell death characterized Circular circular RNA contagious coronavirus demonstrated diarrhea down-regulated epithelial cell line gastroenteritis Hexokinase HK2 IL-6 Infection Infectious disease Inflammation inhibited intestinal microRNA mitochondrial mitochondrial permeability transition pore NF-κB NF-kB pathway NF-κB NF-κB pathway nuclear opening permeability Pore promoted provoke regulate regulated responsible RNA suppressed target targeting TGEV transition transmissible gastroenteritis coronavirus virus vomiting [DOI] 10.7150/ijbs.36532 PMC 바로가기 [Article Type] Research Paper
Recombinant Chimeric Transmissible Gastroenteritis Virus (TGEV)—Porcine Epidemic Diarrhea Virus (PEDV) Virus Provides Protection against Virulent PEDVArticle Published on 2019-07-252022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] addition approach Attenuated Virus caused chimeric coronavirus defined died Effective vaccines Engineering enteric virus epidemic diarrhea evaluate expressing gastroenteritis Genome highlight humoral immune response inactivated indicated Infection Live attenuated vaccine modified live-vaccine morbidity and mortality Neutralizing antibodies outbreak PEDV protection recombinant reducing Spike protein strain TGEV tissue damage undetectable United State vaccine candidate Vaccine development virulent virus virus RNA virus titer were used [DOI] 10.3390/v11080682 PMC 바로가기 [Article Type] Article
UBXN1 interacts with the S1 protein of transmissible gastroenteritis coronavirus and plays a role in viral replicationResearch Article Published on 2019-04-272022-10-28 Journal: Veterinary Research [Category] Coronavirus, [키워드] Antiviral binding cause cDNA library Cell cells clone coronavirus Degradation diarrhea downregulated expression expression level gastroenteritis glycoprotein GST host receptor identify IFN-β in viral indicated Infection inhibition interact intestinal cell intracellular protein involved late phase morbidity and mortality negative control overexpression positive Protein protein domain protein synthesis provided regulate Replication Research responsible Sequencing sialic acid Signal transduction signaling pathways significantly significantly increased siRNA TGEV the S1 protein UBXN1 viral titer yeast [DOI] 10.1186/s13567-019-0648-9 PMC 바로가기 [Article Type] Research Article
The N-Terminal Domain of Spike Protein Is Not the Enteric Tropism Determinant for Transmissible Gastroenteritis Virus in PigletsArticle Published on 2019-03-302022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] accelerate affected approach Bacterial Cas9 cDNA Cell chromosome Clinical sign clone coronavirus CRISPR/Cas9 demonstrated determinant enteric enteric tropism experiment full-length gastroenteritis genetics growth help Mortality mutant N-terminal domain PK-15 platform Protein rescued Research Respiratory Coronavirus reverse genetics spike spike gene Spike protein survival TGEV transmissible gastroenteritis virus tropism Vaccine virulence virus [DOI] 10.3390/v11040313 PMC 바로가기 [Article Type] Article