Serological screening in wild ruminants in Germany, 2021/2022: No evidence of SARS-CoV-2, bluetongue virus or pestivirus spread but high seroprevalences against Schmallenberg virusArticle Published on 2022-09-012022-11-15 Journal: Transboundary and emerging diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome age antibodies antibody betacoronaviruses bluetongue disease bovine viral diarrhoea collected coronavirus COVID-19 deer disease ELISA Germany human SARS-CoV-2 infectious agent investigated no evidence of occurred pandemic pathogenic Pestivirus positive presence of antibody public health RBD risk ruminant ruminants SARS-CoV-1 SARS-CoV-2 scored Serologically serology Spread susceptible tested the RBD the receptor-binding domain the SARS-CoV-2 virus Virus neutralisation while wildlife [DOI] 10.1111/tbed.14600 PMC 바로가기
SARS-CoV-2 VOCs, Mutational diversity and clinical outcome: Are they modulating drug efficacy by altered binding strength?Research article Published on 2022-09-012022-10-05 Journal: Genomics [Category] SARS, 변종, [키워드] Analysis binding comprehensive analysis coronavirus COVID-19 pandemic Delta disease disease severity Drug efficacy Efficacy Genomic surveillance indicate less modulating molecular docking Mortality mutant Mutation mutation analysis NTD omicron outcome patients performed Protein RBD recovered recovered patients respiratory SARS-CoV-2 SARS-CoV-2 genome sequenced significantly spike syndrome T19R the patient the RBD variants of concern VoC VOCs [DOI] 10.1016/j.ygeno.2022.110466 [Article Type] Research article
Immunogenicity and safety of a RBD vaccine against SARS-CoV-2 in a murine modelArticle Published on 2022-09-012022-11-15 Journal: Travel medicine and infectious disease [Category] SARS, 변종, 진단, [키워드] BALB/c mice cellular change control group coronavirus dose group immunogen immunogenic immunogenicity Inflammatory inoculated mice murine model Protein Public public health RBD risk Safe SARS-CoV-2 Seroconversion shown spike spike glycoprotein subunit Surveillance the RBD vaccination Vaccine vaccine candidate variants variants of concern virus were used [DOI] 10.1016/j.tmaid.2022.102427 PMC 바로가기
Comparison of commercial SARS-CoV-2 surrogate neutralization assays with a full virus endpoint dilution neutralization test in two different cohorts두 개의 다른 코호트에서 상용 SARS-CoV-2 대리 중화 분석과 전체 바이러스 종말점 희석 중화 테스트의 비교Article Published on 2022-09-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibody Antibody titers biosafety level Cohort cohorts convalescent Convalescent SARS-CoV-2-infected individuals COVID COVID vaccinated individuals Cutoff detect Determination Dilution Endpoint Full virus neutralization test glycoprotein gold gold standard indicate infected individuals Infection Interaction labor labor-intensive level 3 neutralization Neutralization assay neutralization test neutralization tests Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Qualitative quantitative measurement RBD Receptor binding domain receptor protein Replication SARS-CoV-2 SARS-CoV-2-infected individual spike glycoprotein surrogate surrogate virus neutralization test sVNT the RBD vaccinated individuals Viral viral spike virus Virus neutralization virus neutralization test VNT [DOI] 10.1016/j.jviromet.2022.114569 PMC 바로가기 [Article Type] Article
Longitudinal dynamics of SARS-CoV-2 anti-receptor binding domain IgG antibodies in a wide population of health care workers after BNT162b2 vaccinationArticle Published on 2022-09-012022-11-15 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] acute respiratory syndrome Analysis analyzed Anti-RBD antibody Anti-RBD IgG antibody binding antibody binding domain BNT162b2 BNT162b2 vaccine coronavirus decrease domain doses female female participant HCWs Health care Health care worker health care workers highest highlight Humoral response IgG antibody IgG level immune response Immunoglobulin longitudinal male quantitative assay RBD SARS-CoV-2 second dose Sex significant difference spike glycoprotein Support the RBD the S1 subunit the spike protein the vaccine These data vaccination Vaccines were measured [DOI] 10.1016/j.ijid.2022.05.061 PMC 바로가기
Missense mutations in spike protein of SARS-CoV-2 delta variant contribute to the alteration in viral structure and interaction with hACE2 receptorArticle Published on 2022-09-012022-11-16 Journal: Immunity, Inflammation and Disease [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 receptor Acidic acute respiratory syndrome Alter analyzed circulating computational analysis conformational contribute contributed coronavirus coronavirus disease COVID-19 Defense delta variant disease domain elevated Evidence functional hACE2 receptor help Host Immune escape in viral India induce infection rate Interaction L452R mechanism Missense mutation molecular molecular docking Morphological Mutation mutations Pandemics physiochemical analysis Protein provided respiratory tract infection RNA SARS-CoV-2 SARS-CoV-2 delta spike glycoprotein Spike protein stability T478K the RBD variant variant spike virus [DOI] 10.1002/iid3.683 PMC 바로가기
Antibody Avidity and Neutralizing Response against SARS-CoV-2 Omicron Variant after Infection or VaccinationArticle Published on 2022-08-312022-11-15 Journal: Journal of Immunology Research [Category] SARS, 변종, 진단, [키워드] adenovirus-based antibody Antibody avidity avidity bind binding binding antibody cellular receptor collected cross-protection domain dose elicited epitope exhibit Heterologous high affinity Immunity increase mRNA vaccine Mutation natural infection Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing titer omicron pandemic patients Protective antibody RBD RBD-binding IgG remained response Sample SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 spike protein subject tested the RBD the spike protein vaccination Vaccine vaccine dose vaccinees Vaccines variant virus wild-type wild-type SARS-CoV-2 wild-type virus [DOI] 10.1155/2022/4813199 PMC 바로가기
Affinity of anti-spike antibodies to three major SARS-CoV-2 variants in recipients of three major vaccines Research Published on 2022-08-252022-10-05 Journal: Communications Medicine [Category] 진단, [키워드] ACE2 adaptive affinity Anti-spike anti-spike antibody anti-viral antibody antibody apparent affinity approach binding blocking blood plasma COVID-19 Delta determine develop domain epitope human serum humoral immune response Immunity immunogenic Infection interfere janssen Microparticle Microscope Moderna offer omicron Pfizer Pfizer/BioNTech Protein Quantitative RBD recipient reduced Result SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 virus serum the RBD the spike protein Vaccine vaccine-induced antibody Vaccines variants variety virus [DOI] 10.1038/s43856-022-00174-9 [Article Type] Research
Structural bioinformatics analysis of SARS-CoV-2 variants reveals higher hACE2 receptor binding affinity for Omicron B.1.1.529 spike RBD compared to wild type referenceSARS-CoV-2 변이체의 구조적 생물정보학 분석은 야생형 참조에 비해 Omicron B.1.1.529 스파이크 RBD에 대해 더 높은 hACE2 수용체 결합 친화력을 보여줍니다Article Published on 2022-08-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 신약개발, [키워드] ACE2 binding affinity Alpha Amino acid amino acid substitution amino acid substitutions Analysis B.1.1.529 binding binding affinity Bioinformatics analysis calibrated characterized COVID-19 pandemic develop Effect hACE2 receptor Halo highest hydrophobicity infected with SARS-CoV-2 Interaction linear molecular dynamics Molecular dynamics simulation molecular dynamics simulations much higher new SARS-CoV-2 occurred omicron pandemic RBD Receptor binding domain receptor hACE2 reveal SARS-CoV-2 variant SARS-CoV-2 variants sequence Spread the RBD the SARS-CoV-2 variant variants VoC wild type [DOI] 10.1038/s41598-022-18507-y PMC 바로가기 [Article Type] Article
Genomic surveillance of SARS-CoV-2 by sequencing the RBD region using Sanger sequencing from North KeralaArticle Published on 2022-08-252022-11-16 Journal: Frontiers in Public Health [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] analyzed Community country Follow-up generate genomic Genomic surveillance gold standard hotspot Immune escape India Kerala lab management medium next generation sequencing NGS North nucleotide nucleotide sequence Patient processed Public health interventions RBD Receptor binding domain Region Research Sanger sequencing SARS-CoV-2 SARS-CoV-2 variant Sequencing severity spike gene spike gene sequencing. Surveillance the RBD turn variant variants of SARS-CoV-2 was done [DOI] 10.3389/fpubh.2022.974667 PMC 바로가기