Evidence of SARS-CoV-2 spike protein on retrieved thrombi from COVID-19 patientsCOVID-19 환자로부터 회수된 혈전에서 SARS-CoV-2 스파이크 단백질의 증거Article Published on 2022-08-162022-09-11 Journal: Journal of Hematology & Oncology [Category] SARS, 치료기술, 치료법, [키워드] activate addition analyzed Chain Reaction Coagulopathy complex COVID-19 COVID-19 patient detect evidence of FIBRIN Hypothesis Ischemic Stroke Molecular biology Myocardial infarction nucleocapsid protein ogen pathophysiology pilot study Platelet platelet activation Platelets polymerase chain polymerase chain reaction real-time polymerase chain reaction retrieved SARS-CoV-2 RNA SARS-CoV-2 spike protein Spike protein stroke Support These data thrombi Trigger virus [DOI] 10.1186/s13045-022-01329-w PMC 바로가기 [Article Type] Article
How concerning is a SARS-CoV-2 variant of concern? Computational predictions and the variants labeling systemArticle Published on 2022-08-102022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, [키워드] Analysis approach attribute attributes CDC center computational prediction concerning Control COVID-19 pandemic criteria defined discrepancy Effect evaluated FIVE function Genetic variant Genetic variation labeling Mutation observation predict Predictive Premature prevention SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants the SARS-CoV-2 the United State These data variant variant of interest variant under monitoring variants variants of concern virus VoC VOCs WHO World Health Organization [DOI] 10.3389/fcimb.2022.868205 PMC 바로가기
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variantsSARS-CoV-2 변종을 차단하는 범용 약제로서의 임상 등급 ACE2Article Published on 2022-08-082022-09-11 Journal: EMBO Molecular Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 Alpha analyzed Beta binding affinity caused clinical clinical trial COVID-19 Delta develop Efficacy epithelial cell epithelial cells Gamma human lung human lung epithelial cells independent Infection inhibit inhibited neutralized neutralizing antibody omicron Phase 2 principle proof reduced SARS-CoV-2 isolates SARS-CoV-2 variant SARS-CoV-2 variants several variant several variants soluble ACE2 strain tested therapeutic Therapeutic strategies therapeutic strategy These data Treatment Vaccine variants variants of concern VeroE6 cell VeroE6 cells VoC [DOI] 10.15252/emmm.202115230 PMC 바로가기 [Article Type] Article
Preoperative SARS-CoV-2 Screening Fails to Detect Viral Particles Prior to Airway Surgery수술 전 SARS-CoV-2 스크리닝은 기도 수술 전에 바이러스 입자를 감지하지 못함Article Published on 2022-08-012022-09-11 Journal: The Laryngoscope [Category] SARS, 치료기술, [키워드] adenoid adenoidectomy adenoidectomy. Asymptomatic asymptomatic patient asymptomatic patients Care Chain Reaction Child children collected conducted convenience sampling Course COVID COVID-19 cross-sectional study effect size Evidence evidence of Fail Infection Laryngoscope Level Logistic regression Nasopharyngeal swab nucleic acid Odds ratio Older Particle Patient pediatric polymerase chain reaction positive preoperative Prospective Study protocol question real-time reverse transcription-polymerase chain reaction reverse transcriptase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 particle SARS-CoV-2 particles SARS-CoV-2 viral particle SARS-CoV-2 viral particles Screening specimens surgery surgical These data tissue Total utility variable viral particle Viral particles Viral transmission was used [DOI] 10.1002/lary.29906 PMC 바로가기 [Article Type] Article
COVID-19 mRNA Vaccine in Patients With Lymphoid Malignancy or Anti-CD20 Antibody Therapy: A Systematic Review and Meta-Analysis림프성 악성종양 환자 또는 항-CD20 항체 치료 환자의 코로나19 mRNA 백신: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-08-012022-09-11 Journal: Clinical lymphoma, myeloma & leukemia [Category] 치료제, [키워드] anti-CD20 antibody articles attenuate B-cell B-cell target therapy cellular response Cellular responses chronic lymphocytic leukemia CLL COVID-19 COVID-19 mRNA vaccine COVID-19 mRNA vaccines Effectiveness exhibited humoral Humoral and cellular responses Humoral response independent independent of individual leukemia Long-term follow-up Lymphocytic leukemia lymphoid lymphoma malignancies malignancy material Meta-analysis mRNA mRNA vaccine mRNA vaccines Myeloma Patient PROTECT registration number response to vaccination retrieved review risk risk ratio Seropositivity significantly subtype systematic review T cell T cell responses therapy These data vaccination Vaccine were used within 6 months [DOI] 10.1016/j.clml.2022.03.012 PMC 바로가기 [Article Type] Meta-Analysis
Durability of Heterologous and Homologous COVID-19 Vaccine Boosts이종 및 동종 COVID-19 백신의 내구성 향상Article Published on 2022-08-012022-09-11 Journal: JAMA Network Open [Category] SARS, 변종, 진단, [키워드] Ad26 Ad26.COV2.S Adenovirus age Analysis Antibody Response Antibody responses Asian assays binding black BNT162b2 BNT162b2 vaccine boost Boston CD4+ T-cell CD8+ Cellular immune response cellular immune responses cohort study COVID-19 COVID-19 vaccine cytokine Data analysis declined elicited evaluate evaluated female Follow-up functional antibody response Heterologous heterologous prime-boost Hispanic homologous humoral humoral immune responses immune response immune responses immunization immunogenicity individual intracellular cytokine staining involved IQR Latino Massachusetts median Messenger RNA mRNA mRNA vaccine Neutralizing neutralizing antibodies titer neutralizing antibody occurred of BNT162b2 omicron outcome participant peaked potential benefit potential benefits prime-boost regimen rapid increase regimen repeated response SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants T-cell responses These data Vaccine was performed were assessed white [DOI] 10.1001/jamanetworkopen.2022.26335 PMC 바로가기 [Article Type] Article
Rapid displacement of SARS-CoV-2 variant Delta by Omicron revealed by allele-specific PCR in wastewater폐수에서 대립 유전자 특이적 PCR로 밝혀진 Omicron에 의한 SARS-CoV-2 변이형 Delta의 빠른 변위Article Published on 2022-08-012022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Accuracy allele Alpha B.1.1.529 Clinical studies clinical study Community complement Concentration COVID-19 Delta delta variant demonstrated detect distribution Health immune evasion Infection influent Italy mapped measure Mutation omicron Omicron variant PCR Public health responses qPCR Quantitative Rapid report RNA concentrations RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant SARS-CoV-2 variants Support Surveillance target These data Transmissibility Treatment triggered utility vaccination rates Vaccine breakthrough variant variant frequencies variant frequency VoC wastewater [DOI] 10.1016/j.watres.2022.118809 PMC 바로가기 [Article Type] Article
Impaired humoral and cellular response to primary COVID-19 vaccination in patients less than 2 years after allogeneic bone marrow transplant동종 골수 이식 후 2년 미만의 환자에서 1차 COVID-19 예방 접종에 대한 체액 및 세포 반응 손상Article Published on 2022-08-012022-09-11 Journal: British Journal of Haematology [Category] MERS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 adverse outcome adverse outcomes Allogeneic allogeneic bone marrow transplant analysed anti-S IgG Anti-spike BNT162b2 Bone marrow booster Cell Cell-mediated immunity cellular response ChAdOx1 Cohort coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) Coronavirus-2 COVID-19 COVID-19 vaccination Critical defined enzyme-linked immunospot Evidence evidence of haematopoietic stem cell transplant (HSCT) HCs healthy control high risk HSCT HSCT recipient HSCT recipients humoral IFNγ IgG Immunoglobulin Immunoglobulin G ImmunoSpot Impaired interferon less majority Patient Prophylactic prophylactic measure prophylactic measures rate of seroconversion recipient respiratory responders Seroconversion Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) significantly higher significantly lower stem cell T-cell T-cell Response T-cell responses These data titre Transplant vaccination schedule Vaccination strategy Vaccine vaccine immunogenicity Vaccines variants [DOI] 10.1111/bjh.18312 PMC 바로가기 [Article Type] Article
Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cellsOmicron이 아닌 조상 SARS-CoV-2는 일차 소아 비강 상피 세포에서 덜 효율적으로 복제합니다Article Published on 2022-08-012022-09-11 Journal: PLoS Biology [Category] Coronavirus, SARS, 변종, [키워드] acute respiratory syndrome Adults Air-liquid interface antiviral response Biology biology of SARS-CoV-2 changes in children coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 Delta delta variant epithelial cells Evidence Infection infections less Mild symptom nasal epithelial cell nasal epithelium NEC NECs omicron pediatric replicate replicated Replication respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly lower Support susceptible These data vaccination Viral RNA virus VOCs widespread [DOI] 10.1371/journal.pbio.3001728 PMC 바로가기 [Article Type] Article
Alterations in CD39/CD73 axis of T cells associated with COVID-19 severityCOVID-19 중증도와 관련된 T 세포의 CD39/CD73 축 변경Article Published on 2022-08-012022-09-11 Journal: Journal of cellular physiology [Category] MERS, 바이오마커, 진단, [키워드] Activation adenosine adenosine triphosphate alteration Annexin Apoptosis ATP Blood CD25 CD27 CD28 CD4 CD73 CD8 Cell collected controls coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokines decrease effector cell expression Extracellular Frequency healthy controls healthy donor immune function Immunopathogenesis immunopathology in vitro Inflammation involved knowledge memory T mild COVID-19 patient mild COVID-19 patients modulate Monocytes mononuclear cell nuclear pathway patients PD-1 Peripheral blood plasma samples Purinergic purines purines. reduced Regulation Regulatory Regulatory T cell SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severity Signaling T cell T cells T lymphocytes T-cell These data triphosphate Viral viral infections with COVID-19 [DOI] 10.1002/jcp.30805 PMC 바로가기 [Article Type] Article