Dynamic role of LMW-hyaluronan fragments and Toll-like receptors 2,4 in progression of bleomycin induced lung parenchymal injury to fibrosisResearch Published on 2021-05-212022-10-31 Journal: The Egyptian Journal of Bronchology [Category] COVID-19, [키워드] accumulating acute respiratory syndrome alveolar animal caused cell damage correlated Course damage-associated molecular pattern DAMP DAMPs downregulation dynamic ECM elevate epithelial etiologies euthanized Extracellular matrix fibrosis group Host immune Immunopathogenesis incidence increase increases in Inflammation Inflammatory responses Injury interstitial LMW-hyaluronan lung Lung disease Lung injury Macrophage mRNA NF-κB NF-κB non-infectious pandemic parenchymal potential therapeutic targets pro-inflammatory progression protein levels pulmonary pulmonary fibrosis response Result SARS-CoV-2 significantly tissue inflammation TLR2 TLR4 Toll-like receptor Toll-like receptor 2, 4 upregulation virus [DOI] 10.1186/s43168-021-00073-y PMC 바로가기 [Article Type] Research
Cytotoxic T-lymphocyte elicited vaccine against SARS-CoV-2 employing immunoinformatics frameworkArticle Published on 2021-04-072022-10-04 Journal: Scientific Reports [Category] MERS, SARS, 신약개발, [키워드] acute respiratory syndrome Analysis assays binding binding interaction Biophysics caused Computational biology and bioinformatics coronavirus COVID-19 Critical CTL CTL epitope development effective elicit elicited epitope explicit fluctuation global pandemic Healthcare system Host immune regulators immune response immunization immunodominant immunoinformatics immunological parameter in silico in vitro in vivo information linker magnitude membrane memory cell MHC Molecular docking study Molecular dynamics simulation novel coronavirus disease predicted Protein receptors reduced Region residue RMSD robust SARS-CoV-2 SARS-CoV2 spike glycoprotein Strains T-cell TLR2 Vaccine vaccine candidate Variation [DOI] 10.1038/s41598-021-86986-6 PMC 바로가기 [Article Type] Article
Whole-Transcriptome RNA Sequencing Reveals Significant Differentially Expressed mRNAs, miRNAs, and lncRNAs and Related Regulating Biological Pathways in the Peripheral Blood of COVID-19 Patients전체 전사체 RNA 시퀀싱은 COVID-19 환자의 말초 혈액에서 유의미하게 차별적으로 발현된 mRNA, miRNA, lncRNA 및 관련 조절 생물학적 경로를 나타냅니다Research Article Published on 2021-04-012022-09-10 Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘, [키워드] “cytokine storm” acute respiratory syndrome acute respiratory syndrome coronavirus AKT1 Analysis Antigen antigen processing Biological biosynthetic characterized China coding collected competing control group controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19 sample COVID-19 samples CXCL8 cytokine cytokine production Cytokine storm cytotoxicity diagnostic biomarker Diagnostic biomarkers differentially expressed downregulated enrichment analysis excessive cytokine production FCGR2A Functional enrichment analyses Gene ontology glycogen ground-glass opacity healthy controls healthy donor healthy donors highlight hub genes indicated Inflammation Interaction involved leukocyte leukocytes lncRNA long noncoding RNA lung tissues lymphocyte Lymphocytes mechanism Messenger RNA messenger RNAs microRNA MicroRNAs Migration miRNA miRNAs mRNA mRNAs noncoding RNA Noncoding RNAs pandemic Pathogenesis peripheral Peripheral blood positive potential mechanism potential mechanisms PPI presenting protein-protein interaction Regulating Regulation Regulatory respiratory resulting RNA SARS-CoV-2 selected Sequencing severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 signaling pathway Significant significantly STAT3 systemic inflammation T cell T cell activation target the healthy therapeutic tissue TLR2 TNFRSF1B upregulated [DOI] 10.1155/2021/6635925 PMC 바로가기 [Article Type] Research Article
Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic SuggestionsReview Published on 2021-02-202022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] “cytokine storm” activate Activation acute lung injury acute lung injury (ALI) acute respiratory distress acute respiratory distress syndrome (ARDS) Bacterial Bacterial coinfection characteristic characterized Combination coronavirus COVID-19 Cytokine release syndrome Cytokine storm effective eight Evidence exhibiting fungal fungal coinfection Fungal infection fungal infections healthy control hyperinflammation implication Infection Innate Innate immunity Interaction Involving Making mechanism melatonin microbes Mild mild cases mild COVID-19 patient Model NLR NLRP3 novel nucleotide-oligomer-recognition-domain-like receptors (NLR) oligomerization outlined pattern prediction receptor respiratory resulting review SARS-CoV-2 Sepsis severe COVID-19 severe COVID-19 patients suggestion Symptoms syndrome synergistic synergy therapeutic TLR TLR antagonists TLR2 TLR3 TLR4 TLR7 TLR9 Toll-like receptor toll-like receptors (TLR) treating COVID-19 [DOI] 10.3390/ijms22042108 PMC 바로가기 [Article Type] Review
SARS-CoV-2 spike protein S1 subunit induces pro-inflammatory responses via toll-like receptor 4 signaling in murine and human macrophagesResearch Article Published on 2021-02-022022-10-31 Journal: Heliyon [Category] COVID-19, [키워드] abrogate activate activated Activation acute respiratory syndrome caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine develop Effect examined excessive inflammation experiment exposure to human macrophage human macrophages induce Infectious disease Inflammation Inflammatory inhibitor intracellular signaling involved JNK Macrophage macrophages mechanism Mortality multiple organ failure murine N-terminal neutralizing antibody NF-κB nuclear Pathways Patient pro-inflammatory cytokine pro-inflammatory mediator pro-inflammatory response produced Protein receptor S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein selective severe complication severity Signaling signaling pathways spike Spike protein Spread suggested suppressed the disease THP-1 TLR2 TLR4 toll-like receptor 4 [DOI] 10.1016/j.heliyon.2021.e06187 PMC 바로가기 [Article Type] Research Article
Increased expression of hypoxia-induced factor 1α mRNA and its related genes in myeloid blood cells from critically ill COVID-19 patientsResearch Article Published on 2020-12-212022-10-28 Journal: Annals of Medicine [Category] COVID-19, [키워드] blood cell bronchoalveolar Cell cells cellular cellular response characterized clinical manifestations COVID-19 COVID-19 patient COVID-19 severity Critically ill CXCL8 CXCR1 CXCR2 event events explain Express expressed expression FIVE GAPDH Genes HIF1α hypoxia immature immature myeloid cells Immunopathogenesis Increased Inflammation involved leukocyte lung cell marker metabolism molecular monocyte monocyte-macrophages Monocytes mRNA myeloid cell Neutrophils oxygen levels performed peripheral blood cells PFKFB3 PGK1 physiological response potential molecular precursors regulated Result RNAseq SARS-CoV-2 scRNAseq severe cases SLC2A3 SOD2 subset target targets therapy TLR TLR2 transcription factor transcriptional transcriptionally virus [DOI] 10.1080/07853890.2020.1858234 PMC 바로가기 [Article Type] Research Article
4,4′-Diaminodiphenyl Sulfone (DDS) as an Inflammasome Competitor4,4′-다이아미노디페닐 설폰(DDS) 염증소체 경쟁자로서Article Published on 2020-08-192022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, 한센병, [키워드] 4,4′-diaminodiphenyl sulfone (dapsone) Activation AD Alter Alzheimer’s disease Alzheimer’s disease Antibiotics binding caspase-1 cause cleaved Cognitive impairment Combination DDS demonstrated diagnosed Diseases effective Effects Factor Fever fibrosis genetic polymorphisms Hansen’s disease human disease immune response implicated Inflammasome inflammasomes intracellular domain involved Korean lepromatous leprosy (also known as Hansen’s disease) leprosy ligands LL Lung inflammation MADDS mechanism microbial Mild molecular monoacetyldapsone MPO Mutation myeloperoxidase NACHT, LRR and PYD domains-containing protein 3 NLRP3 NLRP3 inflammasome Parkinson’s disease Patient protein 3 receptor Regulation reported responsible S protein SARS-CoV SARS-CoV-2 Sulfone susceptibility tested TLR TLR2 TLRs Toll-like receptor treated Treatment type 2 diabetes variety viruses zoonotic [DOI] 10.3390/ijms21175953 PMC 바로가기 [Article Type] Article
Designing Multi-Epitope Vaccines to Combat Emerging Coronavirus Disease 2019 (COVID-19) by Employing Immuno-Informatics ApproachImmunology Published on 2020-07-102022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] 3D model ACE2 addressed adjuvants alleles Analysis analyzed B-cell epitopes caused changes in China combat corona vaccine coronavirus COVID-19 domain epitope evaluate evaluated HLA Host immunogenic Interaction linker Multi-epitope vaccine pandemic physiochemical property Predictive Receptor binding S1 and S2 S1 domain S2 domain SARS-coronavirus SARS-CoV-2 single-stranded RNA virus Spike protein Spike proteins T-cell the spike protein therapeutic TLR2 TLR4 Vaccine vaccine candidate vaccine construct viral entry [DOI] 10.3389/fimmu.2020.01663 PMC 바로가기 [Article Type] Immunology
Possible SARS-coronavirus 2 inhibitor revealed by simulated molecular docking to viral main protease and host toll-like receptorResearch Article Published on 2020-06-122022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] adopted Analysis Antiviral applied binding energy COVID-19 determine enrichment functional protein GO and KEGG enrichment analysis Host Inflammatory inhibitor Interaction material metabolic process metabolism molecular docking MPro plants protease Protein rutin SARS-coronavirus SARS-CoV-2 main protease selected target therapeutic TLR TLR2 TLR6 TLR7 TLRs Toll-like receptor Toll-like receptors traditional antiviral medicinal plants [DOI] 10.2217/fvl-2020-0099 PMC 바로가기 [Article Type] Research Article
Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae세균 외부 및 내부화된 세균의 상대적 기여가 폐렴구균에 대한 조기 대식세포의 친염증 반응에 미치는 영향Research Article Published on 2019-09-242024-07-31 Journal: mBio [Category] 폐렴구균 감염증, [키워드] Capsule Inflammation Streptococcus pneumoniae TLR2 [DOI] 10.1128/mBio.02144-19 PMC 바로가기 [Article Type] Research Article