TLR7 – Page 4 – Communicable Diseases Research

Rare variants in Toll-like receptor 7 results in functional impairment and downregulation of cytokine-mediated signaling in COVID-19 patients

Toll-유사 수용체 7의 희귀 변이는 COVID-19 환자에서 기능 손상 및 사이토카인 매개 신호의 하향 조절을 초래합니다

Brief Communication

Published on 2021-12-242022-09-10
Journal: Genes and Immunity [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘,

The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λ

Research Article

Published on 2021-12-222022-10-30
Journal: mSphere [Category] Coronavirus,

[키워드] Air-liquid interface airway epithelium ALI-REC Alpha Antiviral basal cells Betacoronavirus CCL2 CCL5 Cell culture cell cultures cells change chemokine chemokines ciliated cells coronavirus Culture CXCL10 CXCL8 Cytokines cytopathic disease Donor driving epithelia epithelial lining evaluated expression expression level Gene Expression goblet cells homeostasis IFN-λ1 IFN-stimulated gene IFN-λ IFN-λ1 IL-1β IL-6 IL-8 in vitro in vivo Including Increased infect Infection innate immune gene innate immune response Innate immunity innate response interleukin-1β investigated modulation molecular mechanism morphologically Necrosis Neonatal neurotropic OAS1 outcome pattern PHEV primary site Proinflammatory cytokine proliferative Recognition replicate replicated respiratory respiratory epithelia respiratory epithelial cell resulting RIG Stat1 tissue TLR TLR3 TLR7 TNF-α tracheal transcription factor Transcriptional upregulation triggered turn upper respiratory tract upregulation virus vomiting
[DOI] 10.1128/mSphere.00820-21 PMC 바로가기 [Article Type] Research Article

Imiquimod Boosts Interferon Response, and Decreases ACE2 and Pro-Inflammatory Response of Human Bronchial Epithelium in Asthma

Imiquimod는 인터페론 반응을 높이고 ACE2 및 천식에서 인간 기관지 상피의 염증 반응을 감소시킵니다

Immunology

Published on 2021-12-072022-09-11
Journal: Frontiers in Immunology [Category] SARS, 치료법,

[키워드] ACE2 ACE2 expression analyses Analysis analyzed Anti-inflammatory Anti-viral anti-viral cytokine anti-viral cytokines anti-viral drug Anti-viral treatment Asthma asthmatic Asthmatic patients baseline bronchial bronchial epithelial cell COVID-19 COVID-19 infection cytokine cytokine signaling Cytokines decrease donors drug dsRNA dual Effect ELISA epithelial epithelial cells epithelium Ex vivo examined exhibit expression feasibility HBEC HBECs healthy highlight Human IFN signaling IFN-β IL-1β IL-33 IL-6 IL-8 imiquimod IMPROVE infections involved mechanism mRNA multiplex objective pathway poly(I:C poly(I:C) pro-inflammatory pro-inflammatory cytokine pro-inflammatory cytokines producing protective effect proteomic qPCR Receptor binding reduced reducing resistance mechanisms response Result RT-qPCR SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor Severe COVID-19 Infection SP1 spike-protein stimulated subjects suppression target TLR7 TLR7 agonist Tolerance treat Treatment Trigger triggers Viral viral infection viral infections Viral resistance western blot
[DOI] 10.3389/fimmu.2021.743890 PMC 바로가기 [Article Type] Immunology

Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19

여성이 더 잘하는 이유: 코로나19에서 X 염색체 TLR7 유전자 용량 효과

Immunology

Published on 2021-11-112022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법,

[키워드] age biallelic caused concerning contribute COVID-19 COVID-19 pandemic COVID-19 treatment dendritic cells Effect expression Factor female gene-dose effect Hypothesis ICU IFN IFN pathway IFN response Immune cell immune cells Immunopathogenesis inactivation Infection interferon investigated Male sex modulation Mortality Pattern recognition pattern recognition receptor Pattern recognition receptors plasmacytoid dendritic cell plasmacytoid dendritic cells Protective responsible SARS-CoV-2 severe COVID-19 severity Sex difference sex differences sex hormone Sex hormones ssRNA TLR TLR7 TLR7 gene Toll-like receptor Treatment type 1 interferon Viral viral infections X chromosome X chromosome inactivation escape
[DOI] 10.3389/fimmu.2021.756262 PMC 바로가기 [Article Type] Immunology

Candidate genes of SARS-CoV-2 gender susceptibility

Article

Published on 2021-11-092022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

[키워드] acute respiratory syndrome ADAM10 Affect Analysis applied association bioinformatics BST2 candidate cascade CCR5 complement Computational biology and bioinformatics coronavirus COVID-19 disease Effect effective ENPEP evaluate expressed GATA1 Gender Genetic genetics gonadal host cell human protein immunology Infection initiated Interaction IRF1 IRF2 likelihood men molecular outcome ovarian pandemic Pathways performed reaction receptor signaling response SARS-CoV-2 SARS-CoV-2 treatment SERPING1 severity of symptoms Sex difference susceptibility target the SARS-CoV-2 tissue TLR4 TLR7 TMPRSS2 Topic understanding Variation women
[DOI] 10.1038/s41598-021-01131-7 PMC 바로가기 [Article Type] Article

Generation of potent cellular and humoral immunity against SARS-CoV-2 antigens via conjugation to a polymeric glyco-adjuvant

고분자 글리코 보조제에 대한 접합을 통한 SARS-CoV-2 항원에 대한 강력한 세포 및 체액 면역 생성

Article

Published on 2021-11-012022-09-12
Journal: Biomaterials [Category] MERS, SARS, 진단,

[키워드] activate activated adjuvant adjuvants amplified antibody Antigen antigen-presenting cell antigen-specific antibody APCS B cells caused CD4 CD8 cells cellular composed convalescent human serum COVID-19 COVID-19 vaccine Disease model effective elicit follicular generate Generation Glycopolymers Humoral immunity Humoral response IgGs immune response increase in long-lasting mice monomer Neutralizing Neutralizing titer platform Polymer-protein conjugates Polymeric glyco-adjuvant producing Protein protein antigen receptor robust SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 virus secreting shown Spread subunit Subunit vaccine Subunit vaccine formulation. T cell responses T cells the Spike the vaccine TLR7 Toll-like receptor triggering vaccination Vaccine vaccine candidate wild-type yielding
[DOI] 10.1016/j.biomaterials.2021.121159 PMC 바로가기 [Article Type] Article

Evaluation of the Effect of Inactivated Transmissible Gastroenteritis Virus Vaccine with Nano Silicon on the Phenotype and Function of Porcine Dendritic Cells

Article

Published on 2021-10-262022-10-28
Journal: Viruses [Category] Coronavirus, MERS,

X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia

X-연관 TLR7 결핍은 운동실조-모세혈관확장증 남성 환자의 심각한 COVID-19 폐렴의 원인이 됩니다

Case Reports

Published on 2021-10-232022-09-10
Journal: Journal of Clinical Immunology [Category] MERS, 변종, 유전자 메커니즘, 치료기술,

[키워드] antibody Antibody deficiency Asymptomatic Ataxia ataxia-telangiectasia ATM autoantibodies autoantibody candidate gene clinical manifestations conditions coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 immune response COVID-19 pneumonia Critical critical COVID-19 deficiencies deficiency Deleterious Diagnosis disease evaluated exhibit Exome genetic cause genetic defect genetic defects high risk homozygous identify IFNs IgM immune response Immunity Impact inborn errors of immunity individual interferons investigated life-threatening mechanism Mild symptom mild symptoms Mutation neurological signs objective Patient patients evaluated Pneumonia Primary Immunodeficiency radiosensitivity Result SARS-COV-2 infection Sequencing serum levels specific antibodies specific antibody supplementary material syndrome telangiectasia the patient TLR7 TLR7 gene Treatment Type I IFN type I interferon type I interferons underlie understanding unique variant virus was performed were measured
[DOI] 10.1007/s10875-021-01151-y PMC 바로가기 [Article Type] Case Reports

X-linked recessive TLR7 deficiency in 1% of men under 60 years with life-threatening COVID-19

Observational Study

Published on 2021-10-082022-10-04
Journal: Science Immunology [Category] Fulltext, MERS, 변종, 임상, 진단,

SNPs at 3’UTR of APOL1 and miR-6741-3p target sites associated with kidney diseases more susceptible to SARS-COV-2 infection: in silco and in vitro studies

APOL1 및 miR-6741-3p의 3'UTR에 있는 SNP는 SARS-COV-2 감염에 더 민감한 신장 질환과 관련된 부위를 표적으로 함: in silco 및 in vitro 연구

Article

Published on 2021-10-012022-09-11
Journal: Mammalian genome : official journal of the Interna [Category] SARS, 변종, 치료제,

[키워드] Acute kidney injury addition African American AKI angiotensin Angiotensin II APOL1 association binding binding site BRF1 calculated chemokine Chronic kidney disease CKD Collapsing control sample COVID-19 different diseases disease effective Effectiveness evaluate the effect expression first position Gene Expression genetic variants genomic sequence Genotype glomerulopathy GTF2H5 healthy HES2 identify in silico in vitro in vitro study increase increased risk Infection Interaction kidney Kidney disease Kidney diseases Kidney injury lesion Ligand likelihood MAFG Mann-Whitney U test MED12L microRNA MicroRNAs miRNA miRNAs motif NFYB nucleotide Pathways Patient Protein PRSS23 qRT-PCR relative expression reported SARS-COV-2 infection shown single-nucleotide polymorphism SLC6A19 SNP SNPs susceptibility susceptible SWT1 target target gene Target genes TLR7 TRAF3 UTR Variation with COVID-19
[DOI] 10.1007/s00335-021-09880-6 PMC 바로가기 [Article Type] Article