Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?Immunology Published on 2021-05-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] adeno-associated virus antibody antigens Can Clinical efficacy Clinical studies Conventional de novo synthesis Diseases Efficacy Efficiency expression Fighting foreign protein game Gene therapy genomic variation HIV Host Immunity immunomodulatory immunotherapies Immunotherapy in vivo Infection Infectious disease Influenza inherent lentivirus malaria mechanism neutralizing antibody offer passive transfer Pathogens pre-existing immunity profiles Prophylactic reduce repeated Severity of disease single dose tested therapeutic strategy Topology transgene Treatment vaccination Vaccines vectors viral vectors virus [DOI] 10.3389/fimmu.2021.673699 PMC 바로가기 [Article Type] Immunology
Genome-wide proximity between RNA polymerase and DNA topoisomerase I supports transcription in Streptococcus pneumoniaeRNA 폴리머라제와 DNA 토포이소머라제 I 사이의 게놈 차원의 근접성은 Streptococcus pneumoniae의 전사를 지원합니다Research Article Published on 2021-04-302022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] addition Antibiotic resistance Antibiotics Bacteria binding clinically coding regions codon complex death determine develop disease distribution DNA DNA sequence DNA topoisomerase double-stranded Double-stranded DNA drug drug target effective enzyme Enzymes expression Factor functional Gene Expression Genes genome-wide association homeostasis in vitro in vivo indicate Interaction intergenic region intergenic regions Localization MACS mapped Meningitis molecular motif motifs Mycobacterium tuberculosis pair physically pneumococcal Pneumonia pneumoniae prevented promoter promoters Reactions recruit recruited regulate regulated Regulation Replication responsible rifampicin RNA polymerase RNAP Sepsis single-stranded Spread Streptococcus pneumoniae Support surface plasmon surface plasmon resonance target topoisomerase Topology transcript Transcription Treatment Tuberculosis Type type I [DOI] 10.1371/journal.pgen.1009542 PMC 바로가기 [Article Type] Research Article
Examining the diffusion of coronavirus disease 2019 cases in a metropolis: a space syntax approachResearch Published on 2021-04-292022-10-30 Journal: International Journal of Health Geographics [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome adaptive addition Affect applied approach Area bandwidth built environment cause cognitive collected confirmed case confirmed cases Contact contributed coronavirus coronavirus disease correlation COVID-19 COVID-19 case dataset diffusion Effect effective Effects Epidemic Examining Factor geographical distribution geographically weighted regression heterogeneity high-density highlight Hong Kong Human incidence indicated Infectious disease investigated Linear regression model Local measure mechanism pandemic Perspective positive Quantitative Regression required Research respiratory viruses Result selected Space syntax Spread spread of COVID-19 supplementary material Topology Variation [DOI] 10.1186/s12942-021-00270-4 PMC 바로가기 [Article Type] Research
Placing sensors in sewer networks: A system to pinpoint new cases of coronavirus하수도 네트워크에 센서 배치: 코로나바이러스의 새로운 사례를 찾아내는 시스템Research Article Published on 2021-04-082022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 치료기술, [키워드] Algorithm Algorithms attribute Community coronavirus described detect develop exhibiting Genetic homing manhole median MONITOR neighborhood random reduce Stool the mean Topology virus [DOI] 10.1371/journal.pone.0248893 PMC 바로가기 [Article Type] Research Article
Vaccination strategies against COVID-19 and the diffusion of anti-vaccination viewsArticle Published on 2021-03-232022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] adjusted adopted Applied mathematics average benefit central node Consequences COVID-19 COVID-19 crisis Critical diffusion Epidemic group hosts individual misinformation pandemic parameter quarantine reduction Result Risk factors Spread susceptible the disease the vaccine Topology Vaccination strategies Vaccination strategy vaccine administration wearing face mask [DOI] 10.1038/s41598-021-85555-1 PMC 바로가기 [Article Type] Article
Fluorescence-detection size-exclusion chromatography utilizing nanobody technology for expression screening of membrane proteinsArticle Published on 2021-03-192022-10-31 Journal: Communications Biology [Category] Coronavirus, SARS, [키워드] Affect Analysis Chromatography develop expressed expression false-negative False-positive FSEC functional fused GFP High-throughput screening Jin membrane membrane protein Membrane proteins mitigate nanobody peptide powerful tool Proteins purification stability structural biology Topology [DOI] 10.1038/s42003-021-01891-y PMC 바로가기 [Article Type] Article
Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexesResearch Article Published on 2021-03-032022-10-28 Journal: Science Advances [Category] COVID-19, [키워드] acute respiratory syndrome amino acid changes Cluster complementary complex complexes coronavirus enzyme exhibiting hallmark humans infect non-structural protein Nsps pandemic pathway plasticity protein concentrations regulate replication-transcription complex residue RTC SARS-CoV-2 Seven three groups topologies Topology zoonotic coronaviruses [DOI] 10.1126/sciadv.abf1004 PMC 바로가기 [Article Type] Research Article
Structure Unveils Relationships between RNA Virus PolymerasesArticle Published on 2021-02-172022-10-28 Journal: Viruses [Category] COVID-19, [키워드] automated characterized Cluster comparison double-stranded RNA eukaryotic functional homologous hosts infecting mechanism Phylogenetic Phylogenetic tree positive-sense primer Protein protein evolution protein structure RdRP RdRps relationship residue RNA RNA primer RNA virus RNA virus taxonomy RNA viruses RNA-dependent RNA polymerase sequence similarity similarity structural alignment structural conservation Structure structure comparison structures Topology Transcription Viral protein virus [DOI] 10.3390/v13020313 PMC 바로가기 [Article Type] Article
Effects of COVID-19 on Urban Population Flow in ChinaArticle Published on 2021-02-082022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] adjust Affect Analysis average path Baidu Characteristics China Clustering Complex network complex networks analysis concern correlation country COVID-19 COVID-19 epidemic demonstrated Effect effective effective distance model Emergency Epidemic Evolution first stage Flow Health hierarchical structure Isolation Linear regression model Migration positive Public reduction risk Spread stages the epidemic Topology urban population urban population flow Wuhan [DOI] 10.3390/ijerph18041617 PMC 바로가기 [Article Type] Article
HiDeF: identifying persistent structures in multiscale ‘omics dataShort Report Published on 2021-01-072022-11-01 Journal: Genome Biology [Category] Coronavirus, [키워드] Affect Analysis application Cell cell types Clustering Community community detection Cytoscape expand homology identify mathematical Multiscale outcome Persistent homology Protein protein interaction Protein-protein interaction network Resolution robust significantly Single-cell clustering single-cell transcriptome single-cell transcriptomes Structure Systems biology Topology [DOI] 10.1186/s13059-020-02228-4 PMC 바로가기 [Article Type] Short Report