transgenic – Page 4 – Communicable Diseases Research

Stem cell therapies and benefaction of somatic cell nuclear transfer cloning in COVID-19 era

코로나19 시대의 줄기세포 치료제와 체세포 핵이식 복제의 장점

Review

Published on 2021-05-122022-09-12
Journal: Stem Cell Research & Therapy [Category] SARS, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome Anti-inflammatory antivirals ARDS being benefit Bio-pharming boost caused Cell cell type Cell-based therapy cellular Clinical studies cloned COVID-19 COVID-19 patient COVID-19 patients damage dependence develop Drug testing Embryo embryonic embryos generate Genome reprogramming Health health emergency immunomodulatory effect immunomodulatory effects Interaction mesenchymal stem cell Mesenchymal stem cells MSC MSCs nuclear organ Organoid organoids potential benefit potential benefits prominence regenerative regenerative medicine Research respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection SCNT somatic cell STEM stem cell stem cells structures syndrome therapeutic Therapies therapy transfer transgenic treat unique Vaccinations Vascular
[DOI] 10.1186/s13287-021-02334-5 PMC 바로가기 [Article Type] Review

SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental Models

Pharmacology

Published on 2021-04-222022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] ACE-2 acute respiratory syndrome Antiviral blood vessel organoid Calu-3 cause cell line cells clinical sample coronavirus COVID-19 develop drug design Drug discovery epithelial cell epithelial cells experimental model experimental models expression H1299 HEK-293 human Angiotensin-converting enzyme human lung inefficient Infection intestinal epithelial cells Intestinal Organoids investigated Laboratory lung organoids Model molecular molecular target Molecular targets morbidity and mortality mouse model Novel coronavirus outbreak outcomes pandemic Pathogenesis potential molecular Protein recent receptor Research researcher SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection sequencing data spike target targets the SARS-CoV-2 therapeutic transgenic Treatment outcome Vero cells viral genome viral life cycle viral pathogen viral pathogenesis Viral protein viral titer X-ray
[DOI] 10.3389/fphar.2021.638334 PMC 바로가기 [Article Type] Pharmacology

Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunization

COVID-19에 대한 안전하고 효과적인 2-in-1 레플리콘 및 VLP 미니스파이크 백신: 단일 면역 후 마우스 보호

Research Article

Published on 2021-04-212022-09-12
Journal: PLoS Pathogens [Category] MERS, SARS, 진단,

[키워드] animals Antigen antigen expression approach Author boost build candidate caused Cell cell surface chimeric classic Complication concern COVID-19 disease COVID-19 patients COVID-19 vaccine Critical disease domain effective Efficiency emergence of virus encoding enhancement envelope expressing expression functional glycoprotein humans immune response immunization immunogen include induce K18-hACE2 mice mice Neutralizing activity Neutralizing antibodies non-infectious Non-neutralizing antibodies outcome Particles pathogenic problem protection protective immune response Protein Rabies virus RBD RBD antigen Receptor binding domain Replication replication-competent virus replication-competent viruses RNA S antigen Safe SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 pandemic SARS-CoV-2 spike secreted sequence Side effect single dose Spread stimulated transgenic transmembrane tropism of SARS-CoV-2 vaccination Vaccine vaccine platform vectors vesicular stomatitis vesicular stomatitis virus viral DNA virus virus propagation Virus-like particle virus-neutralizing antibody VLP VLPs VSV VSVΔG
[DOI] 10.1371/journal.ppat.1009064 PMC 바로가기 [Article Type] Research Article

Functional analysis of SARS-CoV-2 proteins in Drosophila identifies Orf6-induced pathogenic effects with Selinexor as an effective treatment

Research

Published on 2021-03-252022-11-01
Journal: Cell & Bioscience [Category] COVID-19,

Control of malaria-transmitting mosquitoes using gene drives

Article

Published on 2021-02-152024-08-28
Journal: Philosophical Transactions of the Royal Society B: Biological Sciences [Category] 말라리아,

[키워드] Anopheles CRISPR gene drive Mosquito transgenic vector control

Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection

Research Article

Published on 2020-11-062022-10-31
Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS,

ACE2 mouse models: a toolbox for cardiovascular and pulmonary research

Review Article

Published on 2020-10-142022-10-04
Journal: Nature Communications [Category] MERS, SARS, 변종,

Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

Research Article

Published on 2020-10-022022-10-30
Journal: JCI Insight [Category] COVID-19, MERS,

[키워드] ACE2 Analysis angiotensin-converting enzyme 2 animal model binding Brain infection COVID-19 described develop different dose disease evaluated expressing female groups Health Human human ACE2 human Ace2 protein human disease increases in infected with SARS-CoV-2 Infection Infectious disease Inflammatory Inflammatory cytokines International intranasal involved K18 K18-hACE2 knowledge low-dose lung Lung injury male mice Molecular pathology Mouse models murine pathogenesis of SARS-CoV-2 promoter Protein Respiratory disease SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis survival transcript transgenic transgenic mice weight loss
[DOI] 10.1172/jci.insight.142032 PMC 바로가기 [Article Type] Research Article

Structural and functional modelling of SARS-CoV-2 entry in animal models

Article

Published on 2020-09-282022-10-29
Journal: Scientific Reports [Category] COVID-19, SARS,

[키워드] ACE2 ACE2 receptor affected Analysis animal model animal models approach binding binding mode complex Contact country COVID-19 disease effective expressing facilitate ferret functional glycoprotein hACE2 Host human ACE2 indicate influence inhibitory antibody Interaction lack molecular docking Molecular modelling Novel coronavirus outbreak protease Protein Research responsible SARS-CoV SARS-CoV-2 SARS-CoV-2 entry sequence variability small molecule specificity spike spread to susceptibility the SARS-CoV-2 the Spike TMPRSS2 transgenic Transgenic mouse viral entry viral infection Viral proteins
[DOI] 10.1038/s41598-020-72528-z PMC 바로가기 [Article Type] Article

Evaluation of K18- hACE2 Mice as a Model of SARS-CoV-2 Infection

Articles

Published on 2020-09-282022-10-28
Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, SARS,