Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 ComplexBeclin 1은 뉴런 생존에 필요하고 UVRAG-VPS34 복합체를 통해 엔도솜 경로를 조절합니다Research Article Published on 2014-10-022022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity addition animal model assembly autophagosome autophagy Beclin 1 Brain cause cell line cellular characterized Complete complex complexes conditions Coordinate deficiency disease Diseases Disruption distribution EEA1 endocytosis endosome Endosomes Evidence failure function Genetic human disease impair impairment implicated in addition to in vivo Infectious disease Interaction involved leads maintain mammalian maturation membrane molecular mechanism mutant neurodegeneration neurodegenerative Neuron neuronal neurons nucleation organelle overexpressed p40 pathway Pathways phosphatidylinositol phosphatidylinositol 3-kinase physiological PI3K Previous studies previous study Protein recent recruit recruitment regulate Regulation required rescued reveal RUBICON survival tumorigenesis UVRAG viability [DOI] 10.1371/journal.pgen.1004626 PMC 바로가기 [Article Type] Research Article
Regulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescencep53 및 Rb의 조절은 대체 NF-κB 경로를 EZH2 발현 및 세포 노화에 연결합니다Research Article Published on 2014-09-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated Activation alternative NF-κB pathway Analysis ANAPC1 c-Rel cancer cell Cancer cells CD40 CD40 ligand CD40L CDK4 CDK6 Cell cell cycle cell senescence cellular senescence ChIP chromatin immunoprecipitation chronic chronic lymphocytic leukemia classical complexes Crosstalk de-repression defined Degradation DEK dependent on Effect effector effectors expression EZH2 fibroblasts Hematological malignancies Hematological malignancy IKK IKKα induce inhibit investigated IκB IκBα knockdown leads Loss Lymphocytic leukemia mechanism microarray analysis microenvironment NEMO NF-κB NF-κB inducing kinase NF-κB pathway NF-κB2 NIK or canonical oxygen p100 p21WAF1 p52 p53 pathway patients phenotype Phosphorylation polycomb protein promote protein stability provide PSMA5 quantitative PCR RacGAP1 reactive oxygen species reactive oxygen specy regulate Regulation regulatory subunit RELA RelB repression retinoblastoma retinoblastoma protein ROS SASP senescence senescent siRNA solid tumors stability stimulated subset subunit subunits suppress suppression target gene Target genes the cell Tumor tumor suppressor tumorigenesis tumors tumour suppressor turn western blot Western blot analyses Western blot analysis wild type [DOI] 10.1371/journal.pgen.1004642 PMC 바로가기 [Article Type] Research Article