Beneficial effects of a mouthwash containing an antiviral phthalocyanine derivative on the length of hospital stay for COVID-19: randomised trialCovid-19의 입원 기간에 대한 항 바이러스 프탈로시아닌 유도체를 함유하는 구강 세척의 유익한 효과 : 무작위 시험Randomized Controlled Trial Published on 2021-10-072022-08-13 Journal: Scientific Reports [Category] MERS, SARS, 임상, 치료기술, 치료제, [키워드] adjuvant Admission age anionic phthalocyanine derivative Antiviral antiviral activity Antiviral effect antiviral effects APD association both groups Care clinical clinical condition clinical study clinical trial Comorbidities Compound conducted Contamination control group COVID-19 cytotoxicity death demonstrated dissemination duration of symptom Effect effective evaluated experimental group group Health Organization hospital hospital discharge Hospital stay hospitalized patient ICU ICU care in both group in vitro indicated infected with SARS-CoV-2 Infection intensive care unit Intervention LOS Mouthwash mouthwash protocol nasal nonactive mouthwash number of comorbidities Patient pharyngeal photoexcitation phthalocyanine positive presence of comorbidities protocol Randomised trial Randomized controlled trial reduce reduced reducing reduction Registered Research risk SARS-CoV-2 SARS-CoV-2 viral load severity of symptom Sex significantly Spread standard care Symptom tested the median the patient Treatment Trial registration triple-blind triple-blind randomized controlled trial Two-arm Viral World Health Organization [DOI] 10.1038/s41598-021-99013-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Rationale and Methods for a Randomized Controlled Trial of a Dyadic, Web-Based, Weight Loss Intervention among Cancer Survivors and Partners: The DUET StudyArticle Published on 2021-09-292022-10-31 Journal: Nutrients [Category] COVID-19, [키워드] age Biomarker Cancer Cancer survivors Characteristics Controlled COVID-19 described diet dyads effective intervention enrolled Enrollment exclusion exercise Glucose Health homeostasis identify Inflammation Internet Intervention lifestyle Loss obesity performed physical activity Physical inactivity precluded Primary outcome promote Randomized controlled trial Randomly rationale RCT recruited Regulation Result rising secondary outcome Support survivor Survivors Two-arm Waist circumference weight weight loss [DOI] 10.3390/nu13103472 PMC 바로가기 [Article Type] Article
Prevention of SARS-CoV-2 (COVID-19) transmission in residential aged care using ultraviolet light (PETRA): a two-arm crossover randomised controlled trial protocol자외선 (PETRA)을 사용한 주거 노화 치료에서 SARS-COV-2 (COVID-19) 전송 예방 : 2ARM 크로스 오버 무작위 대조 시험 프로토콜Study Protocol Published on 2021-09-172022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 임상, 치료기술, [키워드] addition adjunct baseline benefit Care care providers changes in Characteristics clinical Complication conducted Contact contribute Controlled trial correlation COVID-19 COVID-19 outbreak crossover detect determine droplet transmission effective Efficacy Evidence facility focus followed by genomic germicidal Germicidal ultraviolet light hand hygiene Health care quality hospitalisation hygiene incidence rate incidence rates include Infection infection control infection rate initial Intervention Laboratory measure Measures morbidity and mortality Mortality multicentre New Other respiratory viruses outcome partnership pathogen transmission Prevent prevention Primary outcome protocol randomised randomised controlled trial rate ratio reduce reducing reduction in Registered registry Residential aged care respiratory Respiratory illness respiratory illnesses respiratory infection respiratory infections respiratory viral respiratory virus Respiratory virus infection respiratory viruses risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 transmission secondary Secondary outcomes separated severe disease social distancing South Spread symptomatic symptomatic infection Transmission transmission of SARS-CoV-2 Two-arm ultraviolet ultraviolet light Viral vulnerable population zone [DOI] 10.1186/s12879-021-06659-7 PMC 바로가기 [Article Type] Study Protocol
The Positive Modulation Effect of a 6-Week Consumption of an Anthocyanin-Rich Mulberry Milk on Working Memory, Cholinergic, and Monoaminergic Functions in Healthy Working-Age AdultsResearch Article Published on 2021-08-312022-10-29 Journal: Oxidative Medicine and Cellular Longevity [Category] COVID-19, [키워드] acetylcholinesterase addition age assigned baseline cholinergic cognitive Consumption COVID-19 pandemic demonstrated Effect ENhance Evidence function High dose impairment in both group mechanism memory men and women milk occur Open-label randomized study Randomly reduction Saliva Stress study period subject suppresse tested Two-arm Volunteer was determined were assessed working working stress [DOI] 10.1155/2021/5520059 PMC 바로가기 [Article Type] Research Article
The EPIPHA-KNEE trial: Explaining Pain to target unhelpful pain beliefs to Increase PHysical Activity in KNEE osteoarthritis – a protocol for a multicentre, randomised controlled trial with clinical- and cost-effectiveness analysisEpipha-Knee 시험 : 무릎 골관절염의 신체 활동을 증가시키기위한 도움이되지 않는 통증 신념을 목표로하는 통증 설명-임상 및 비용 효율성 분석을 통한 다중 센터, 무작위 통제 시험을위한 프로토콜Study Protocol Published on 2021-08-282022-09-10 Journal: BMC Musculoskeletal Disorders [Category] 임상, [키워드] activity addition adverse events Analysis Anxiety baseline benefit best Blinding both groups clinical Controlled trial Cost-utility analysis COVID-19 Depression determine effective evaluate exercise Explaining finding Follow-up followed by general education group implementation inactive include increase intensity Intention Intervention knowledge life measure movement multicentre multicentre randomised controlled trial New nine Osteoarthritis outcome outcomes Pain pain intensity Pain science education parallel-design physical activity physical activity levels Physiotherapy Primary outcomes Program protocol Quality of life randomised controlled trial RCT receive receiving recommendation secondary Secondary outcomes Self-efficacy sensitivity Strengthening program Stress supplementary material Symptom telehealth Total Treatment Trial Two-arm Walking program [DOI] 10.1186/s12891-021-04561-6 PMC 바로가기 [Article Type] Study Protocol
Protocol for the Controlled evaLuation of Angiotensin Receptor blockers for COVID-19 respIraTorY disease (CLARITY): a randomised controlled trialCOVID-19 호흡기 질환에 대한 안지오텐신 수용체 차단제의 통제된 평가를 위한 프로토콜(CLARITY): 무작위 통제 시험Study Protocol Published on 2021-08-282022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] 7-point ordinal scale accumulating ACE2 activities activity adaptive angiotensin Angiotensin II angiotensin receptor blocker Angiotensin receptor blockers angiotensin-converting enzyme 2 ARB ARBs AT1R Bayesian adaptive design bind blinded blocked CLARITY clinical commenced Controlled Controlled trial COVID-19 COVID-19 severity daily dose death determine disease downregulation Effect Effectiveness enzyme High-risk patients include India interim analysis membrane membrane-bound Mortality offer Open-label Ordinal Scale outcome Placebo Pragmatic Predictive primary endpoint pro-fibrotic pro-inflammatory Probability randomised controlled trial RAS RCT receptor receptor blocker Receptor Blockers recruitment reduce reducing registry Renin renin-angiotensin system respiratory respiratory outcomes responsible Safe Sample size SARS-CoV-2 secondary Secondary outcomes Standard of care supplementary material supply Treatment treatment allocation Trial Trial registration Two-arm [DOI] 10.1186/s13063-021-05521-0 PMC 바로가기 [Article Type] Study Protocol
Sleeping for two: study protocol for a randomized controlled trial of cognitive behavioral therapy for insomnia in pregnant women2인용 수면: 임산부의 불면증에 대한 인지 행동 요법의 무작위 대조 시험을 위한 연구 프로토콜Study Protocol Published on 2021-08-122022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] actigraphy aims assessment behavioral therapy build CBT child health children cognitive cognitive behavioral therapy conducted consequence COVID-19 pandemic death Depression developmental Diagnosis distress during pregnancy Effectiveness ENhance enrolled evaluate finding gestation Health IMPROVE individual Insomnia Intervention lead Long terms mother occur open parallel group physical distancing Pregnancy pregnant women Preterm birth Primary outcome problems Randomized controlled trial RCT reduce reduced risk reducing repeated measure repeated measures Research risk Secondary outcomes Sleep Sleep disturbance Sleep disturbances Study protocol Symptom symptom severity symptoms of depression Tau telehealth therapy treat Treatment treatment as usual Trial Trial registration Two-arm used to evaluate [DOI] 10.1186/s13063-021-05498-w PMC 바로가기 [Article Type] Study Protocol
Statistical analysis plan for a pragmatic phase III randomised controlled trial examining behaviour change physiotherapy intervention to increase physical activity following hip and knee replacements: the PEP-TALK trialClinical Trial Published on 2021-07-202022-10-04 Journal: Trials [Category] SARS, 임상, [키워드] activity adverse events analysed Analysis analysis plan approach Behaviour change Complication Controlled COVID-19 pandemic database declines described Effect Effectiveness ENhance evaluate Evidence extremity Full detail include instance Intervention ISRCTN Joint replacement kinesiophobia linear Lower Osteoarthritis outcome Oxford Pain physical activity Pragmatic Primary outcome provide randomisation randomised controlled trial reduce rehabilitation risk scale score secondary Secondary outcomes sensitivity analysis Standard statistical analysis Statistics Study protocol therapy Total Trial Two-arm usual care usual care alone [DOI] 10.1186/s13063-021-05362-x PMC 바로가기 [Article Type] Clinical Trial
The Retornus-2 study: impact of respiratory muscle training in subacute stroke patients with dysphagia, study protocol of a double-blind randomized controlled trialRetornus-2 연구: 연하곤란이 있는 아급성 뇌졸중 환자의 호흡 근육 훈련의 영향, 이중 맹검 무작위 대조 시험 연구 프로토콜Study Protocol Published on 2021-06-252022-09-10 Journal: Trials [Category] MERS, SARS, 임상, [키워드] aspiration benefit blinded body composition Complication control group COVID-19 outbreak data set death description develop double-blind dysfunction Dysphagia Efficacy event events expiratory fiberoptic endoscopic Follow-up help ICTRP impairment IMPROVE individual induce intervention group lead Malnutrition Muscle strength nutritional status Oropharyngeal Participation Patient portal Primary outcome protocol randomized clinical trial randomized controlled study Randomized controlled trial recent reduce reduction in Registered Registration rehabilitation respiratory muscle Respiratory muscle strength Respiratory muscle training respond secondary outcome severity Side-effect stroke Study protocol suffered supplementary material swallowing impairment training Trial Two-arm videofluoroscopy WHO [DOI] 10.1186/s13063-021-05353-y PMC 바로가기 [Article Type] Study Protocol
Telmisartan for treatment of Covid-19 patients: An open multicenter randomized clinical trialResearch article Published on 2021-06-182022-10-05 Journal: EClinicalMedicine [Category] 임상, 치료법, [키워드] 1:1 95% CI ACE2 adaptive added Admission adverse event age Analysis angiotensin Anti-inflammatory effects ARB ARBs blocker Buenos Aire Buenos Aires C-reactive protein (CRP Community Completed Composite Control COVID-19 criteria CRP CRP level Day death discharge enrolled enzyme expressed finding funding groups hospital Hospitalized hospitalized patient ICU inhibitor intensive care interim analysis Kaplan-Meier analysis Lung inflammation mechanical ventilation median morbidity and mortality multicenter Open-label outcome parallel-group participant Patient plasma Pragmatic randomization Randomized randomized clinical trial receptor recruitment reduce reduction in reported Safe secondary Serum level standard care standard care group symptom onset telmisartan therapeutic to define treat Treatment treatment arm Trial Two-arm was reduced [DOI] 10.1016/j.eclinm.2021.100962 [Article Type] Research article