Clinical Utility of Elecsys Anti-SARS-CoV-2 S Assay in COVID-19 Vaccination: An Exploratory Analysis of the mRNA-1273 Phase 1 TrialCOVID-19 백신 접종에서 Elecsys Anti-SARS-CoV-2 S 어세이의 임상적 유용성: mRNA-1273 1상 시험의 탐색적 분석Clinical Trial Published on 2022-01-192022-09-11 Journal: Frontiers in Immunology [Category] 임상, 치료기술, [키워드] 2019-nCoV absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-SARS-CoV-2 S antibody antibody levels automated baseline choice clinical clinical utility collected coronavirus correlated correlation COVID-19 Day detectable dose Elecsy ELISA ELISAs first vaccination geometric mean geometric mean concentration healthy heterogeneous humoral immune response increases in injection International international standard mRNA mRNA-1273 nanoluciferase neutralization test neutralization tests Neutralizing antibodies participant Participants Phase 1 phase 1 trial Protein pseudovirus neutralizing antibody pseudovirus neutralizing antibody assay quantification Quantitative quantitative serology RBD RBD ELISA RBD-specific antibodies RBD-specific antibody Receptor binding domain respiratory Result Roche S-2P Sample SARS-CoV-2 second vaccination Seroconversion seroconverted severe acute respiratory syndrome Coronavirus shown specific antibodies specificity Spike protein the Spike U/mL vaccination Vaccine vaccine-induced antibody response WHO [DOI] 10.3389/fimmu.2021.798117 PMC 바로가기 [Article Type] Clinical Trial
Humoral and cellular immunity in convalescent COVID-19 people with multiple sclerosis treated with ofatumumab오파투무맙으로 치료받은 다발성 경화증 환자의 회복기 COVID-19 환자의 체액 및 세포 면역Article Published on 2022-01-152022-09-11 Journal: Journal of neuroimmunology [Category] 임상, 진단, [키워드] Administered all subject all subjects antibodies Antibody Response Antibody testing CD19 CD19+ Cell cellular immunity Clinical outcome convalescent COVID-19 COVID-19 infection COVID-19 symptoms COVID-19 vaccination COVID-19 vaccinations dose ELISPOT four subject humoral IgG antibodies IgG antibody IgM IgM and IgG Immunity interferon interferon-γ lymphocyte mediated immunity Mild Multiple multiple sclerosis not performed Ofatumumab PCR performed Quotient reactive SARS-CoV-2 secreting single center subject T cell T-cell T-cell immunity Testing treated U/mL was performed was used while [DOI] 10.1016/j.jneuroim.2021.577788 PMC 바로가기 [Article Type] Article
Age-Dependent Reduction in Neutralization against Alpha and Beta Variants of BNT162b2 SARS-CoV-2 Vaccine-Induced ImmunityBNT162b2 SARS-CoV-2 백신 유도 면역의 알파 및 베타 변이체에 대한 중화의 연령 의존적 감소Research Article Published on 2021-12-012022-09-10 Journal: Microbiology Spectrum [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age All participants anti-RBD antibody antibody level antibody levels Antibody test Antigen basic Beta binding domain BNT162b2 BNT162b2 vaccine Clinical characteristics collected Coronavirus-2 correlated Cutoff decrease female groups Health care Health care worker health care workers heterogeneity high risk higher risk Humoral immunity Immunity include individual Infection interquartile range introduced IQR median mRNA vaccine mRNA vaccines neutralization Neutralizing Neutralizing activity Neutralizing antibodies of BNT162b2 Older age participant Patient patient age positive Pseudotyped virus questionnaire Questionnaires Randomly Receptor-binding domain reduction respiratory SARS-CoV-2 SARS-COV-2 infection second dose selected sera serum dilution Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein Toyama U/mL university vaccination variant variants Viral viral variant Viral variants virus viruses was obtained were measured wild type wild-type wild-type SARS-CoV-2 wild-type virus [DOI] 10.1128/Spectrum.00561-21 PMC 바로가기 [Article Type] Research Article
Analysis of antibody responses after COVID-19 vaccination in liver transplant recipients and those with chronic liver diseases간 이식 환자 및 만성 간 질환 환자의 코로나19 백신 접종 후 항체 반응 분석Article Published on 2021-12-012022-09-12 Journal: Journal of hepatology [Category] MERS, SARS, 진단, [키워드] adjusted antibody Antibody Response chronic liver disease cirrhosis CLD Clinical efficacy COVID-19 vaccination COVID-19 vaccine defined dose Efficacy enrolled evaluate Factors immune response Immunocompromised Immunocompromised patient Immunosuppression Immunosuppressive medication Johnson & Johnson liver liver transplant median titer medication Moderna mRNA vaccine multivariable analysis Patient patient population patients performed Pfizer Poor Prospective Study recipient recipients responses SARS-CoV-2 SARS-CoV-2 vaccination Serious Adverse Events single dose Spike protein Trial U/mL undetectable vaccination Vaccine [DOI] 10.1016/j.jhep.2021.08.008 PMC 바로가기 [Article Type] Article
Evaluation of Humoral Immune Response after SARS-CoV-2 Vaccination Using Two Binding Antibody Assays and a Neutralizing Antibody Assay2개의 결합 항체 분석 및 중화 항체 분석을 사용한 SARS-CoV-2 백신 접종 후 체액 면역 반응의 평가Research Article Published on 2021-11-242022-09-12 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, 치료기술, [키워드] Abbott Abbott Laboratories Abbott SARS-CoV-2 IgG acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Administered antibody Antibody assays Antibody detection automated BNT162b2 ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine collected concordance rate coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 Cutoff demonstrated elicited evaluate first vaccination Genscript Healthcare Diagnostics humoral humoral immune response Humoral response humoral responses IgG Inc. indicated Ireland mitigate Multiple nCoV neutralization test Neutralizing antibodies neutralizing antibody of BNT162b2 pandemic predict Quantitative quantitative value quantitative values response robust SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 neutralization second vaccination seropositive serum sample serum samples severe acute respiratory syndrome Coronavirus Siemen Siemens Sligo suggested U/mL USA Vaccinations Vaccine Vaccines venous blood virus neutralization test was obtained [DOI] 10.1128/Spectrum.01202-21 PMC 바로가기 [Article Type] Research Article
sFlt-1 and CA 15.3 are indicators of endothelial damage and pulmonary fibrosis in SARS-CoV-2 infectionSARS-COV-2 감염에서 SFLT-1 및 CA 15.3은 내피 손상 및 폐 섬유증의 지표입니다.Article Published on 2021-10-072022-08-31 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, [키워드] analysed association Biomarkers Clinical severity clinician common complications consolidation COVID-19 COVID-19 pandemic CT finding disease severity Diseases endothelial damage endothelial injury fibrosis Ground-glass opacities ground-glass opacity Health care Hospitalization hospitalizations ICU include interstitial interstitial pneumonia investigated Laboratory lung lung damage Lung disease Lung diseases Lung fibrosis marker Medical research multiorgan disease non-ICU patients parameter Patient pulmonary fibrosis risk ROC AUC SARS-COV-2 infection SARS-CoV-2 patient Sepsis serum Serum level serum levels severity significantly increased the disease thrombosis Treatment U/mL [DOI] 10.1038/s41598-021-99470-y PMC 바로가기 [Article Type] Article
Humoral response rate and predictors of response to BNT162b2 mRNA COVID19 vaccine in patients with multiple myeloma다발성 골수종 환자의 체액 반응률 및 BNT162b2 mRNA COVID19 백신 반응 예측인자Article Published on 2021-10-012022-09-12 Journal: British Journal of Haematology [Category] MERS, SARS, 진단, [키워드] Adverse antibody Antibody Response BNT162b2 BNT162b2 mRNA BNT162b2 vaccine clinically Control controls COVID19 COVID19 vaccine disease drug effective evaluated event Factor General population healthy volunteer Humoral response hypogammaglobulinaemia independent Infection median age median titer Multiple Multiple myeloma Multivariate analysis occurred Older age Patient patients predictor Prospective Study provide provided reduced risk Safe serological response significantly tested Treatment U/mL Vaccine [DOI] 10.1111/bjh.17608 PMC 바로가기 [Article Type] Article
Serum Krebs von den Lungen-6 levels are associated with mortality and severity in patients with coronavirus disease 2019혈청 Krebs von den Lungen-6 수준은 2019년 코로나바이러스 질환 환자의 사망률 및 중증도와 관련이 있습니다Article Published on 2021-09-012022-09-11 Journal: Respiratory investigation [Category] MERS, SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome Admission an area analyzed ARDS arterial partial pressure of oxygen cardiovascular center coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cutoff value determine disease disease severity enrolled fraction Hospitalized Japanese Krebs von den Lungen-6 medical record medical records Mortality negative correlation nonsurvivor nonsurvivors on admission outcome oxygen partial pressure Patient patients with COVID-19 Predictive Prognosis progressed reported respiratory Respiratory Center respiratory distress Respiratory distress syndrome sensitivity serum severe disease severity significantly specificity survivor syndrome the disease U/mL [DOI] 10.1016/j.resinv.2021.04.002 PMC 바로가기 [Article Type] Article
Antibody response to SARS-CoV-2 vaccination is extremely vivacious in subjects with previous SARS-CoV-2 infectionSARS-CoV-2 백신 접종에 대한 항체 반응은 이전 SARS-CoV-2 감염이 있는 피험자에서 극도로 활발합니다.Article Published on 2021-07-012022-09-12 Journal: Journal of medical virology [Category] MERS, SARS, 진단, [키워드] 95% confidence interval acute respiratory syndrome Adverse Analysis applied asymptomatic infection coronavirus coronavirus disease COVID-19 dose dosing schedule Elecsy event Health care humoral Humoral immunity Immunity immunoassay immunologically individual infected individual injection interquartile range Messenger RNA Modifying mRNA mRNA vaccine naïve naïve individual naïve individuals non parametric test non-inferiority pandemic Pearson correlation SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination second dose single dose single vaccine specific antibody spike m-RNA vaccine. spike RBD subject the median U/mL vaccination Vaccine vaccine injection were measured [DOI] 10.1002/jmv.26982 PMC 바로가기 [Article Type] Article
The first Chinese national standards for SARS-CoV-2 neutralizing antibodySARS-CoV-2 중화항체 중국 최초 국가표준Article Published on 2021-06-232022-09-12 Journal: Vaccine [Category] MERS, SARS, 진단, [키워드] accelerated antibody approved assigned Biological Biological product China Chinese Committee comparability contribute coronavirus disease Coronavirus disease 2019 COVID-19 Degradation determined by drug Efficacy immunogenicity IMPROVE lab milliliter National national standards Neutralization assay neutralization titer neutralization titers neutralizing antibody potency product reduce reference standard Reference standards respiratory Sample SARS-CoV-2 SARS-CoV-2 neutralizing antibody Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 stability Standard therapeutic Therapeutics U/mL Vaccine Variation variations [DOI] 10.1016/j.vaccine.2021.05.047 PMC 바로가기 [Article Type] Article