VEGF – Page 4 – Communicable Diseases Research

Cell therapy in patients with COVID-19 using Wharton’s jelly mesenchymal stem cells: a phase 1 clinical trial

Wharton 's Jelly Mesenchymal 줄기 세포를 사용한 Covid-19 환자의 세포 요법 : 1 상 임상 시험

Clinical Trial

Published on 2021-07-162022-08-13
Journal: Stem Cell Research & Therapy [Category] SARS, 임상,

Placental growth factor level in plasma predicts COVID-19 severity and in-hospital mortality

혈장의 태반 성장 인자 수준은 COVID-19 심각성과 병원 내 사망률을 예측합니다

Article

Published on 2021-07-012022-09-11
Journal: Journal of thrombosis and haemostasis : JTH [Category] SARS, 바이오마커,

[키워드] 95% CI 95% confidence interval adjusted Admission age Analysis Angiogenesis Angiogenic association best Biomarker body mass body mass index C-reactive protein circulating coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 adult patients COVID-19 infection COVID-19 patients COVID-19 severity Cox proportional hazard model D-dimer diagnostic endothelial endothelial injury enrolled FGF-2 fibroblast fibroblast growth factor growth factor hospitalized patient in-hospital mortality Infection Kaplan-Meier survival curve Level logistic regression model marker Mild Mortality Odds ratio Outpatient Patient patients hospitalized placental placental growth factor plasma PlGF positive predict Predictive receiver operating characteristic respiratory Respiratory disease severity significantly survival analysis survival curve the disease Therapeutic approach Vascular vascular inflammation VEGF was performed were measured with COVID-19
[DOI] 10.1111/jth.15339 PMC 바로가기 [Article Type] Article

Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning

기계 학습을 사용하여 디코딩된 COVID-19 심각도 및 만성의 면역 기반 예측

Immunology

Published on 2021-06-282022-09-12
Journal: Frontiers in Immunology [Category] MERS, SARS, 진단,

[키워드] activated T cells Activation activities analyzed approach B-cell bioinformatics CCL3 CCL4 CCR5 CD14+ CD16+ CD4 CD8 characterized chemokines Classifier continuum COVID COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient cytokine Cytokines dataset defined disease dysregulated effective effector T cell elevated excessive inflammation expressing generate GM-CSF healthy control healthy controls identify IFN-γ IL-10 IL-2 IL-4 IL-6 IL-8 immune response implicated individual individuals induce investigated Ligand machine learning Model mononuclear cell PASC Patient PBMCs Peripheral blood plasma positive predict prediction pro-inflammatory random recruitment second significantly significantly lower subset Symptoms T cell activation T-cell T-regulatory cell treatment strategy VEGF virus while
[DOI] 10.3389/fimmu.2021.700782 PMC 바로가기 [Article Type] Immunology

Exploratory analysis to identify the best antigen and the best immune biomarkers to study SARS-CoV-2 infection

SARS-CoV-2 감염 연구를 위한 최고의 항원 및 최고의 면역 바이오마커를 식별하기 위한 탐색적 분석

Research

Published on 2021-06-262022-09-10
Journal: Journal of Translational Medicine [Category] MERS, SARS, 바이오마커, 치료기술,

[키워드] acute COVID-19 Analysis Antibody Response Antigen approach AUC best Biomarker Biomarkers Clinical characteristics cohorts COVID-19 demonstrated described develop diagnostics discriminant analysis Disease progression Eotaxin evaluate evaluated Factor FGF foundation G-CSF GM-CSF HCV help highest identify IFN-γ IFN-γ IL-10 IL-12p70 IL-13 IL-17A IL-1ra IL-1β IL-2 IL-4 IL-5 IL-6 IL-7 IL-8 IL-9 immune immune factors immune response Immunity immunogenic immunogenicity induce Infectious disease IP-10 knowledge MCP-1 membrane MIP-1α MIP-1β not affect nucleoprotein ORF3a partial least square Patient PDGF peptide peptide pool peptides RANTES recent recovered patients Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine SARS-CoV2 SARS-CoV2 infection serological spike Spike-based vaccine spike-protein T-cell T-cell Response TNF-α Treatment strategies Tuberculosis Vaccine vaccine candidates vaccine trial VEGF Viral Viral antigen virus Whole-blood
[DOI] 10.1186/s12967-021-02938-8 PMC 바로가기 [Article Type] Research

Soluble Neuropilin-1 Response to Hypoglycemia in Type 2 Diabetes: Increased Risk or Protection in SARS-CoV-2 Infection?

Endocrinology

Published on 2021-06-232022-10-31
Journal: Frontiers in Endocrinology [Category] COVID-19, MERS, SARS,

[키워드] ACE ACE inhibitors ACE2 activated ADAM9 AGT Angiotensin-converting enzyme aptamer case-control study Cell class clinical co-expressed cofactor Control controls COVID-19 determine disintegrin elevated endothelial ENhance enzyme Glucose growth factor hypoglycemia Increased increased risk inhibitor Ligand mechanism Neuropilin-1 no difference not differ not different NRP1 plasma plasma protein promote protection Protective proteolytic RAS Registration remained REN response Result SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection SEMA3A serum slow stratified Stress subject subsequent System T2D therapy Type type 2 diabete type 2 diabetes VEGF
[DOI] 10.3389/fendo.2021.665134 PMC 바로가기 [Article Type] Endocrinology

He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic Study

Pharmacology

Published on 2021-06-182022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory distress syndrome adjuvant Analysis ARDS Bupleurum can be used CCL2 Chinese Clinical efficacy Clinical practice combination therapy component composed conducted coronavirus disease Coronavirus disease 2019 COVID-19 Cytoscape Decoction Effect endothelial Fever GeneCard Glycyrrhiza uralensis growth factor he-jie-shen-shi decoction IL1B Inflammatory response inheritance inhibiting viral replication involved KEGG Kyoto Ligand Lung injury Man MAPK MAPK signaling MAPK3 mechanism mechanisms Medicine monotherapy Necrosis Negative conversion network network pharmacology nine notable nucleic acid oxidative stress p53 pathway Pathways Patient Pharmacology Pinellia ternata Potential PPI predict Protein Protein–protein interaction PTGS2 receptor required Result retrospective cohort study screened Scutellaria baicalensis selected severe COVID-19 shown suggested syndrome System T cell receptor target TCMSP therapeutic therapy TNF Toll-like receptor Tongji Hospital TP53 Traditional Traditional Chinese medicine treat Vascular VEGF VEGFA Wuhan
[DOI] 10.3389/fphar.2021.700498 PMC 바로가기 [Article Type] Pharmacology

Unbiased Analysis of Temporal Changes in Immune Serum Markers in Acute COVID-19 Infection With Emphasis on Organ Failure, Anti-Viral Treatment, and Demographic Characteristics

장기 실패, 항 바이러스 치료 및 인구 통계 학적 특성에 중점을 둔 급성 코비드 -19 감염에서 면역 혈청 마커의 시간적 변화에 대한 편견없는 분석

Immunology

Published on 2021-06-112022-08-31
Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 진단,

[키워드] 48 hour 48 hours Admission age analyzed Biomarker Biomarkers CCL23 CD28 change chemokine chemokines collected condition convalescent plasma correlated Course COVID-19 COVID-19 admission Deceased decorin demographic demographics demonstrated elevated failure GzmB heterogeneity Hydroxychloroquine ICU identification IL-15 IL-18 immune immunological increased expression individual kidney Kidney failure lack LAG3 LAMP3 ligands Longitudinal studies MCP MCP-1 MCP-3 monocyte Mortality Older age pathology pleiotrophin positively correlated programmed death Protein proteomics remdesavir Remdesivir respiratory serum serum levels Serum Marker Seven severity of COVID-19 steroid Steroids target Temporal the disease therapeutic TNFRSF21 Variation VEGF with COVID-19
[DOI] 10.3389/fimmu.2021.650465 PMC 바로가기 [Article Type] Immunology

Exosomes contribution in COVID-19 patients’ treatment

Commentary

Published on 2021-05-312022-10-30
Journal: Journal of Translational Medicine [Category] COVID-19, SARS,

Identification of selected genes associated with the SARS-CoV-2: a therapeutic approach and disease severity

Review

Published on 2021-04-232022-10-28
Journal: Bulletin of the National Research Centre [Category] COVID-19,

[키워드] ACE2 ARDS Beta blood pressure Brain can be used China complex condition coronavirus Cytokines develop disease severity early diagnosis endosomal pathway Fever Genes highlight host cell identification IL-2 immune system individual Inflammation interleukin involved MERS-CoV Neurological symptom non-structural protein pandemic of COVID-19 positive-sense single-stranded RNA Potential biomarker problem reducing respiratory problems SARS-CoV SARS-CoV-2 selected severe complication syndrome the Coronaviridae the SARS-CoV-2 Therapeutic approach TNF VEGF Viral pneumonia viral RNA synthesis virus was recorded WHO with COVID-19 worldwide pandemic Wuhan
[DOI] 10.1186/s42269-021-00540-y PMC 바로가기 [Article Type] Review

Clinical and Immunological Factors That Distinguish COVID-19 From Pandemic Influenza A(H1N1)

유행성 인플루엔자 A(H1N1)와 COVID-19를 구별하는 임상 및 면역학적 요인

Clinical Trial

Published on 2021-04-212022-09-12
Journal: Frontiers in Immunology [Category] MERS, 신종인플루엔자, 임상, 진단,

[키워드] acute respiratory distress syndrome acute respiratory syndrome alveolar CCL11 CCL3 characterized clinical clinically coronavirus coronavirus disease COVID-19 COVID-19 cases COVID-19 pandemic cytokine levels demonstrated diagnostic Diseases dry cough Factor Frequency G-CSF Gastrointestinal symptom Health Hemisphere histological histopathological IFN-γ IL-10 IL-12 IL-13 IL-1ra IL-1β IL-4 IL-5 IL-6 immune factor Immune profile immune response immunological characteristics induce Inflammatory response Influenza Influenza A(H1N1) pdm09 interstitial Lung pathology Lungs other respiratory virus pandemic pandemic influenza patients patients with COVID-19 Pneumonia respiratory symptoms SARS-CoV-2 severe disease manifestation Th1 Th2 tissue injury TNF-α TSLP unique VEGF
[DOI] 10.3389/fimmu.2021.593595 PMC 바로가기 [Article Type] Clinical Trial