viral life cycle

[키워드] (RdRp 3CLpro ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-apoptotic Anti-inflammatory antiviral properties Apoptosis assembly autophagy BCL-2 can be used caused celastrol cell death cell death pathways Chloroquine chloroquine/hydroxychloroquine Compound coronavirus CoV infection COVID-19 COVID-19 treatment Critical Curcumin cysteine Cytokines death deaths Effect Efficacy enzyme expression FIVE flavonoids Frame group Helicase host cell Hydroxychloroquine induce Infection Inflammation inhibiting inhibitor Inhibitory effects interactions involved L-cysteine life cycle mechanism mitigate modify molecular target molecules MPro name natural natural compounds necroptosis NF-κB NF-κB signaling NLRP3 inflammasome non-structural protein nonstructural protein 1 nsp1 Nsp12 occurred Open reading frame ORF7a outcomes Papain play roles PLPro Potential progression proliferation promote Propagation protease Protein proteinase pyroptosis RdRP Regulated cell death Replication responsible RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV infection SARS-CoV-2 SARS-CoV-2-infected patients Serine serine 2 severe acute respiratory syndrome Coronavirus Signaling small molecule specific inhibitor spike Spike protein survival target targeted therapy the disease therapeutic targeting TMPRSS2 TNF transmembrane transmembrane protease serine 2 Treatment variety Viral viral entry viral infection viral life cycle virions XIAP yielding
[DOI] 10.3390/molecules26247459 PMC 바로가기 [Article Type] Review