Heat shock protein 70 could enhance porcine epidemic diarrhoea virus replication by interacting with membrane proteinsResearch Article Published on 2021-10-302022-10-28 Journal: Veterinary Research [Category] Coronavirus, MERS, [키워드] assays Cell cells cellular complex diarrhoea downregulated early stage ENhance Epidemic expression Heat shock heat shock protein heat shock protein 7 Hsp70 immunofluorescence immunoprecipitation Infection investigated M protein membrane membrane protein MOST overexpression PEDV Porcine epidemic diarrhoea virus Protein protein expression reduction in Replication resulting significantly structural protein virions virus virus replication [DOI] 10.1186/s13567-021-01006-9 PMC 바로가기 [Article Type] Research Article
Comment on “Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2”"오스트리아에서 발생한 슈퍼전파 사건의 게놈 역학은 SARS-CoV-2의 돌연변이 역학 및 전염 특성을 보여줍니다"에 대한 논평Article Published on 2021-10-272022-09-11 Journal: Science Translational Medicine [Category] SARS, 변종, 유전자 메커니즘, [키워드] bottleneck Comment deep sequencing Epidemiology indicate reveal SARS-CoV-2 superspreading event Transmission virions [DOI] 10.1126/scitranslmed.abh1803 PMC 바로가기 [Article Type] Article
In vivo characterization of emerging SARS-CoV-2 variant infectivity and human antibody escape potential새로운 SARS-CoV-2 변이체 감염성과 인간 항체 탈출 가능성의 생체 내 특성화Article Published on 2021-10-192022-09-11 Journal: Cell Reports [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 airway animals antibody antibody isotypes binding coronavirus coronavirus disease Coronavirus disease 2019 correlations COVID-19 E484K Human human coronavirus immune Immune escape in vitro in vivo in vivo modeling India Infection Interaction K417N L452R Los Angeles Lungs mice N501Y nasopharynx neutralization Neutralizing antibodies neutralizing antibody phenomenon plasma pseudovirus pseudovirus infection RBD receiving Receptor binding domain Reinfection respiratory respiratory infection SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus South Africa spreads susceptibility titers transferred Transmissibility variant variants virion virions virulence [DOI] 10.1016/j.celrep.2021.109838 PMC 바로가기 [Article Type] Article
Defining the Innate Immune Responses for SARS-CoV-2-Human Macrophage InteractionsSARS-CoV-2-인간 대식세포 상호작용에 대한 타고난 면역 반응 정의Immunology Published on 2021-10-042022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] Activation activity acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 ARDS characterized chemokine component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm dendritic cells dysregulation end-organ end-organ disease Evidence evidence of expression Host human monocyte human monocyte-derived macrophages IFN immune Infection Inflammation Inflammatory Innate innate immune innate immune response Interaction interferon investigated life-threatening coronavirus disease Macrophage macrophages malfunctions monocyte-macrophage Monocytes mononuclear phagocyte mononuclear phagocytes morbidities pro-inflammatory pro-inflammatory cytokine profile proteomic proteomics receptor respiratory respiratory distress Respiratory distress syndrome response robust SARS-CoV-2 SARS-CoV-2 receptor severe acute respiratory syndrome Coronavirus signaling pathways syndrome systemic inflammation the SARS-CoV-2 tissue damage transcriptomic transcriptomics type I interferon Viral viral infection viral replication virion virions while [DOI] 10.3389/fimmu.2021.741502 PMC 바로가기 [Article Type] Immunology
The roles of lipids in SARS-CoV-2 viral replication and the host immune responseReview Published on 2021-09-292022-10-29 Journal: Journal of Lipid Research [Category] COVID-19, [키워드] AA, arachidonic acid ACE2, angiotensin-converting enzyme 2 acute respiratory syndrome affecting Antiviral strategies ARDS, acute respiratory distress syndrome cell membrane cellular metabolism cholesterol coronavirus COVID-19 cysLT, cysteinyl leukotriene DC, dendritic cell eicosanoid Eicosanoids EPA, eicosapentaenoic acid Host immune response IAV, influenza A virus identify Infection IPr, IP receptor knowledge LA, linoleic acid Lipid lipid composition lipid mediator lipid metabolism Lipidomics LOX, lipoxygenase LPL, lysophospholipid mechanism membrane MERS-CoV, Middle East respiratory syndrome related coronavirus morbidity and mortality NPC1, NPC intracellular cholesterol transporter 1 offer PG, prostaglandin PGI2, prostacyclin Phospholipids receptor regulate RO, replication organelle RSV, respiratory syncytial virus S, spike S1P, sphingosine-1-phosphate SARS-CoV-2 SARS-CoV-2 viral replication SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SK, sphingosine kinase sphingolipids SR-B1, scavenger receptor B type 1 therapeutic Tx, thromboxane viral burden viral entry viral infection viral life cycle virions virus [DOI] 10.1016/j.jlr.2021.100129 PMC 바로가기 [Article Type] Review
In vivo structure and dynamics of the SARS-CoV-2 RNA genomeArticle Published on 2021-09-282022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 치료제, [키워드] 3′-UTR 5′-UTR addition Analysis Antiviral strategies canonical Cell conformation develop discontinuous transcription domain Evidence facilitate functional Genome genome organization help in vivo Intensive Interaction Local Regulating Regulation Replication reveal RNA RNA genome RNA secondary structure SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA sequences Structure the SARS-CoV-2 Transcription translation translational viral life cycle viral replication virions weakened [DOI] 10.1038/s41467-021-25999-1 PMC 바로가기 [Article Type] Article
Just Seeing Is Not Enough for Believing: Immunolabelling as Indisputable Proof of SARS-CoV-2 Virions in Infected Tissue단지 보는 것만으로는 충분하지 않습니다.Article Published on 2021-09-132022-09-10 Journal: Viruses [Category] SARS, 변종, 치료법, [키워드] analysed approach Cell cells correlative microscopy electron microscopy Enough Evidence followed by IHC Immunoelectron microscopy immunohistochemistry immunolabelling light microscopy methodological Microscopy morphology nasopharyngeal Nucleocapsid proteins paraffin-embedded pathologist Pathologists performed proof Protein SARS-CoV-2 SARS-CoV-2 nucleocapsid SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 virion SARS-CoV-2 virions Structure structures subsequent tissue transmission electron microscopy Ultrathin sections variant Viral viral particle virion virions [DOI] 10.3390/v13091816 PMC 바로가기 [Article Type] Article
Acute SARS-CoV-2 infections harbor limited within-host diversity and transmit via tight transmission bottlenecks급성 SARS-CoV-2 감염은 숙주 내 다양성이 제한적이며 엄격한 전송 병목 현상을 통해 전송됩니다.Research Article Published on 2021-08-232022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] bottleneck can be used characterized circulating Combination Community consensus genome Control Course Critical dataset Diversity epidemiologically Evidence Evolution generate genetic diversity Host hosts Immune escape individual individuals infected individual infected individuals Infection infections iSNVs Laboratory Lineage majority Metrics nucleotide pace phylogenetically raised RNA virus RNA viruses SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 lineage sequenced Single nucleotide variant Transmission transmitted understanding unique variant variants Variation virions virus viruses [DOI] 10.1371/journal.ppat.1009849 PMC 바로가기 [Article Type] Research Article
Direct Evidence of Active SARS-CoV-2 Replication in the Intestine장에서 활동적인 SARS-COV-2 복제의 직접적인 증거Major Articles and Commentaries Published on 2021-08-012022-09-06 Journal: Clinical Infectious Diseases: An Official Publicat [Category] Communicable Disease, MERS, SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 carried Clinical data clinically collected Colon coronavirus coronavirus disease Coronavirus disease 2019 coronavirus virion cough COVID-19 diagnosed with COVID-19 Direct discharge discharged distribution electron microscopy eosin epithelial cells evaluate Evidence evidence of explain Fecal–oral transmission Fever Follow-up hematoxylin hematoxylin-eosin stain histopathological examination hospital Hospitalization Ileostomy Immune cell immunofluorescence Immunohistochemical analysis Incubation period infiltrating intestinal epithelial cell intestinal epithelial cells intestinal infection rectal cancer intestinal mucosa intestinal tract intestine investigated lamina propria lymphocyte Lymphocytes Macrophage macrophages Microscopy mucosal damage nucleic acid pathological change pathological changes Patient patients positive provided rectal adenocarcinoma rectal mucosa rectal specimen rectal specimens rectal tissue rectal tissues rectum Replication respiratory Result reverse transcriptase RNA RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 replication SARS-CoV-2 virion SARS-CoV-2 virions severe acute respiratory syndrome Coronavirus specimen succus entericus surgical surgical rectal tissue surgical rectal tissues surgical resection surgical specimen surgical specimens Typical Ultrathin section Ultrathin sections virion virions was performed [DOI] 10.1093/cid/ciaa925 PMC 바로가기 [Article Type] Major Articles and Commentaries
Airway and Alveoli Organoids as Valuable Research Tools in COVID-19Review Published on 2021-07-212023-06-15 Journal: ACS Biomaterials Science & Engineering [Category] MERS, SARS, [키워드] 3D cell models coculture lung respiratory disorders SARS-CoV-2 virions [DOI] 10.1021/acsbiomaterials.1c00306 PMC 바로가기 [Article Type] Review