Virological – Page 4 – Communicable Diseases Research

Antibodies from convalescent plasma promote SARS-CoV-2 clearance in individuals with and without endogenous antibody response

회복기 혈장의 항체는 내인성 항체 반응이 있거나 없는 개인에서 SARS-CoV-2 제거를 촉진합니다

Clinical Trial

Published on 2022-06-152022-09-11
Journal: The Journal of Clinical Investigation [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술,

Clinical and genomic data of sars-cov-2 detected in maternal-fetal interface during the first wave of infection in Brazil

브라질의 첫 번째 감염 파동 동안 산모-태아 경계면에서 검출된 sars-cov-2의 임상 및 게놈 데이터

Article

Published on 2022-06-012022-09-11
Journal: Microbes and infection [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술,

[키워드] abortion Americas Apoptosis B.1.1.28 B.1.1.33 Brazil circulating clinical Clinical virology contribute coronavirus fetal Fetal placenta First wave FIVE genomes genomic data gestation Ground-glass opacities ground-glass opacity highest hospital hospital discharge IgM Illumina Miseq in viral indicate induction of apoptosis Infection interferon involved Lineage Lungs Maternal Mild molecular virology mother Mutation Neonatal infection Newborn nonsynonymous mutation Nonsynonymous mutations Nsp12 Nsp3 ORF3 ORF7b outcome Pathways Phylogeny Placenta pregnant women Preterm birth preterm births Protein qPCR Replication reported RT-qPCR SARS-CoV-2 SARS-COV-2 infection secretion Sequencing South spontaneous abortion state stillborn symptomatic symptomatic cases tested treated umbilical Umbilical cord vertical transmission viral replication Virological virus women
[DOI] 10.1016/j.micinf.2022.104949 PMC 바로가기 [Article Type] Article

Antigenic and virological properties of an H3N2 variant that continues to dominate the 2021-22 Northern Hemisphere influenza season

2021-22 북반구 인플루엔자 시즌을 계속 지배하는 H3N2 변이체의 항원 및 바이러스 특성

Article

Published on 2022-05-312022-09-11
Journal: Cell Reports [Category] 변종,

Clinical Management of Patients With B-Cell Depletion Agents to Treat or Prevent Prolonged and Severe SARS-COV-2 Infection: Defining a Treatment Pathway

장기간의 중증 SARS-COV-2 감염을 치료하거나 예방하기 위한 B-세포 고갈 제제를 사용하는 환자의 임상 관리: 치료 경로 정의

Article

Published on 2022-05-272022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제,

[키워드] Activation Adverse drug reactions agent anti-CD20 anti-CD20 agent anti-SARS-CoV-2 anti-SARS-CoV-2 monoclonal antibody antibody Antiviral B cell B-cell B-cells depletion Case series case sery Characteristics clinical collected Combined therapy convalescent convalescent plasma COVID-19 COVID-19 patient Day demographic demographic characteristics Depletion effective enrolled glycoprotein hospitalized patient Hypogammaglobulinemia immune Immunocompromised Immunocompromised patients Immunosuppressed immunosuppressed patients Immunotherapy Infection Infectious diseases Inpatient interstitial pneumonia intravenous Italy kinetic Lazzaro Spallanzani longitudinal study mandatory median medical history monoclonal monoclonal antibodies monoclonal antibody Neutralizing antibodies outcome oxygen Passive immunotherapy Patient patients persistence Prolonged Protein RDV risk Rome SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe SARS single-center spike spike glycoprotein Spike protein steroid Steroids subjects T cell T cell activation T cells the patient therapy treated treated patient Treatment Virological with COVID-19
[DOI] 10.3389/fimmu.2022.911339 PMC 바로가기 [Article Type] Article

The Biological Functions and Clinical Significance of SARS-CoV-2 Variants of Corcern

Review

Published on 2022-05-202022-10-06
Journal: Front Med (Lausanne) [Category] 진단,

[키워드] ACE2 acute respiratory syndrome Affect Alpha variant Angiotensin-converting enzyme antigenic B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Biological blunt Brazil Characteristics clinical Combination convalescent individuals coronavirus country COVID-19 COVID-19 vaccines Deleterious Deletion Delta delta variant E484K E484K mutation Efficacy ENhance evade FIVE function Gamma Genetic immune evasion India Infection influence immune response insertion K417 Mutation mutations N501Y Neutral Neutralizing antibodies neutralizing antibody omicron optimism other variant P.1 pathogenicity phenotype promote raise RBD Receptor binding domain Region Reinfection risk SARS-CoV-2 SARS-CoV-2 variant sensitivity severe disease Significance South Africa Spike protein Spread spread to Strains the Alpha variant the Beta variant the Delta variant the Gamma variant the Omicron variant the RBD the SARS-CoV-2 the SARS-CoV-2 genome the spike protein the United State The United States Transmissibility triggered United Kingdom vaccination Vaccine-induced immunity Vaccines variant variant of concern variants of concern viral cell viral replication Virological virus VoC VOCs
[DOI] 10.3389/fmed.2022.849217 PMC 바로가기 [Article Type] Review

Assessment of Recovery Time, Worsening, and Death among Inpatients and Outpatients with COVID-19, Treated with Hydroxychloroquine or Chloroquine plus Azithromycin Combination in Burkina Faso

부르키나파소에서 하이드록시클로로퀸 또는 클로로퀸과 아지트로마이신 조합으로 치료한 COVID-19 입원 환자 및 외래 환자의 회복 시간, 악화 및 사망 평가

Observational Study

Published on 2022-05-012022-09-11
Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 치료제,

The puzzling mutational landscape of the SARS-2-variant Omicron

SARS-2 변종 오미크론의 수수께끼 같은 돌연변이 환경

Article

Published on 2022-05-012022-09-11
Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

[키워드] ACE-2 receptor affected antibody antibody susceptibility association cleavage site Complete coronavirus decrease deletions delta variant dissemination electrostatic Epitopes Evolution explain geometric human population immunological Infection initial initial assessment insertion less molecular mechanism molecular mechanisms mutations N-terminal domain neutralizing epitope neutralizing epitopes NTD omicron Omicron variant parameter Pathogenesis pathogenic phenotype predicted RBD Receptor-binding domain SARS Coronavirus SARS-CoV-2 variant Spike protein surface potential the receptor-binding domain Transmission Vaccine variant Virological virulence virus virus classification
[DOI] 10.1002/jmv.27577 PMC 바로가기 [Article Type] Article

Optimizing antiviral therapy for COVID-19 with learned pathogenic model

학습된 병원성 모델로 COVID-19에 대한 항바이러스 요법 최적화

Article

Published on 2022-04-272022-09-11
Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 임상, 치료기술, 치료법, 치료제,

Convalescent plasma treatment in severely immunosuppressed patients hospitalized with COVID-19: an observational study of 28 cases

Observational Study

Published on 2022-04-012022-10-04
Journal: Infectious diseases (London, England) [Category] Coronavirus, COVID19(2023년), SARS, 임상,

[키워드] acute respiratory syndrome antibodies case sery cause CCP clinically convalescent convalescent plasma convalescent plasma treatment coronavirus COVID-19 COVID-19 infection decrease defined died Efficacy heterogeneous group Hospitalized hospitalized patient Immunocompromised patients immunosuppressed patient Immunosuppression In-hospital lymphoma pandemic Patient patients patients hospitalized PCR performed plasma Prospective randomized trial retrospective rituximab SARS-CoV-2 severe immunosuppression Severe infection standard treatment Study design symptom duration treated Treatment Treatment outcome Viremia Virological
[DOI] 10.1080/23744235.2021.2013528 PMC 바로가기 [Article Type] Observational Study

Sequential dynamics of virological and serological changes in the serum of SARS-CoV-2 infected patients

SARS-CoV-2 감염 환자의 혈청 내 바이러스 및 혈청학적 변화의 순차적 역학

Article

Published on 2022-04-012022-09-11
Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, 치료기술,

[키워드] acquisition acute respiratory syndrome acute respiratory syndrome coronavirus Admission analyzed antibody Antibody Response Chain Reaction changes in collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Culture cytopathic discharge dropped faster Follow-up highest Hospitalization IgG immune response Immunological response infected patient infected patients investigated knowledge median Mild Mild symptom mild symptoms moderate moderate symptoms neutralization test Neutralizing antibodies neutralizing antibody Patient polymerase chain polymerase chain reaction Protein provide real-time polymerase chain reaction remained respiratory respiratory sample Respiratory samples Ribonucleic acid Sample SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 spike protein SARS-CoV-2 viral load serological serum serum sample severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein surrogate surrogate virus neutralization test Symptoms Test Total undetectable Viral viral culture Viral load Viremia Virological virus
[DOI] 10.1002/jmv.27518 PMC 바로가기 [Article Type] Article