Efficacy and safety of Bufei Huoxue capsules in the management of convalescent patients with COVID-19 infection: A multicentre, double-blind, and randomised controlled trialCOVID-19 감염이있는 회복기 환자 관리에서 Bufei Huoxue 캡슐의 효능 및 안전성 : 다중 센터, 이중 맹검 및 무작위 대조 시험Randomized Controlled Trial Published on 2022-02-102022-08-31 Journal: Journal of ethnopharmacology [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] adverse event adverse events assessment attenuate baseline Bufei Huoxue capsules Chest computed tomography Chest CT China Chinese Chinese Materia Medica Computed tomography Controlled trial convalescent patient coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 convalescence COVID-19 infection double-blind Effect Efficacy Efficacy and safety estimate evaluate exclusion Exercise Tolerance exhibited fatigue functional Functional status greater IMPROVE improvement Improvements indicated inventory management manifestation materia medica medications multicentre multiple organs not significant Patient physiological Placebo placebo group Pneumonia pneumonia lesion pneumonia lesions Previous studies previous study Primary outcome Primary outcomes randomised controlled trial randomly divided receiving recovering from COVID-19 recruited rehabilitation score significantly Symptom TCM the placebo group Tolerance Traditional Chinese medicine Treatment turn two patients with COVID-19 worldwide pandemic [DOI] 10.1016/j.jep.2021.114830 PMC 바로가기 [Article Type] Randomized Controlled Trial
Characterization of Two Heterogeneous Lethal Mouse-Adapted SARS-CoV-2 Variants Recapitulating Representative Aspects of Human COVID-19인간 COVID-19의 대표적인 측면을 요약하는 두 가지 이종 치명적인 마우스 적응 SARS-CoV-2 변이체의 특성화Immunology Published on 2022-02-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome angiotensin angiotensin-converting enzyme 2 animal model Antiviral applied aspect Asymptomatic BLP vaccine caused cellular tropism characterization characterized clinical manifestation contributed convalescent coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokine storm E protein Efficacy hACE2 high viral replication Host hosts Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro lethal Lower respiratory tract lymphopenia mACE2 mechanism mice moderate morbidity and mortality mouse model mouse-adapted SARS-CoV-2 much higher murine Mutation neutralization capacity neutrophilia New Pathogenesis pathogenicity platform promote Protective Pulmonary pathology RBD receptor Receptor-binding domain receptors reported Research respiratory SARS-CoV-2 SARS-CoV-2 variants serum severe COVID-19 patients Substitution switching the receptor-binding domain therapeutic approaches Transmissibility upper and lower respiratory tract Vaccine vaccine candidate variant variants Viral virulence worldwide pandemic [DOI] 10.3389/fimmu.2022.821664 PMC 바로가기 [Article Type] Immunology
The use of convalescent plasma therapy in the management of a pregnant woman with COVID-19: a case reportCase Report Published on 2022-02-022022-10-31 Journal: Einstein [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] addition Administered antibodies, neutralizing bases blood test C-reactive protein Case report chest X-ray clinical picture convalescent plasma Convalescent plasma therapy coronavirus disease Coronavirus infections COVID-19 D-dimer early administration gestation high-flow oxygen therapy Hospitalized lung management Methylprednisolone Mild Neutralizing antibodies neutralizing antibody onset of symptoms oxygen saturation Patient plasma Pregnancy Pregnancy complications, infectious Pregnant woman pro-calcitonin Prophylaxis required responsible Safe SARS-CoV-2 antibody severe COVID-19 therapy Treatment with COVID-19 worldwide pandemic worsened [DOI] 10.31744/einstein_journal/2022RC6550 PMC 바로가기 [Article Type] Case Report
Identifying SARS-CoV-2 ‘memory’ NK cells from COVID-19 convalescent donors for adoptive cell therapyClinical Trial Published on 2022-02-012022-10-05 Journal: Immunology [Category] COVID19(2023년), SARS, 임상, [키워드] Blood Cell cell therapy. characteristic clinical trial convalescent coronavirus COVID-19 COVID-19 convalescent donor COVID-19 patient disease Donor donors expression HLA identifying indicate Infection infections innate immune system KIR lymphopenia memory natural killer cell NK cell NK cells phenotype SARS-CoV-2 severity shown Symptoms syndrome therapy treat virus-infected cell worldwide pandemic [DOI] 10.1111/imm.13432 PMC 바로가기 [Article Type] Clinical Trial
COVID-19 diagnosis from routine blood tests using artificial intelligence techniquesResearch article Published on 2022-02-012022-10-05 Journal: Biomedical Signal Processing and Control [Category] 변종, [키워드] Accuracy AUC average blood test blood tests can be used clinician Clinicians correlation coefficient COVID-19 COVID-19 diagnosis dataset datasets deep learning diagnose diagnosing Diagnosis disease feature highest imperative Interpretation Laboratory machine learning MCC Mutation Pearson positive Precision recall routine blood test sensitivity Seven Spearman specificity statistical t-test transmission rates unique virus was used were used worldwide pandemic [DOI] 10.1016/j.bspc.2021.103263 [Article Type] Research article
Improvement of SARS-COV-2 screening using pooled sampling testing in limited RT-qPCR resources제한된 RT-qPCR 리소스에서 풀링 샘플링 테스트를 사용한 SARS-COV-2 스크리닝 개선Article Published on 2022-02-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 치료기술, [키워드] Algeria Analysis approach center collected coronavirus country COVID-19 COVID-19 pandemic diagnostic Dilution effective Health Health crisis help identify IMPROVE improvement individual limit mathematical molecular Molecular tests nasopharyngeal swabs pandemic Pasteur Institute pool pooling Pooling samples testing positive positive sample reduced reducing reduction representing required resource RNA RT-qPCR RT-qPCR test RTqPCR SARS-CoV-2 detection SARS−COV-2 Screening screening strategy screening tests sensitivity shown subjects Swab unit cost worldwide pandemic [DOI] 10.1016/j.jviromet.2021.114421 PMC 바로가기 [Article Type] Article
Re-purposing of hepatitis C virus FDA approved direct acting antivirals as potential SARS-CoV-2 protease inhibitorsResearch article Published on 2022-02-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] acting Analysis Antiviral approach approved binding binding affinity binding energy binding site caused clinical trial correlation COVID-19 Cys145 Direct Direct Acting Antivirals (DAAs) docked docking drug drug re-purposing enzyme examined exhibiting FDA food Glu166 HCV hepatitis C hepatitis C virus HIS163 His41 homolog IC50 identify in silico inhibitor investigated MPro Mpro protease New coronavirus protease protease inhibitors provide Replication reported Repurposed drugs SARS-CoV-2 SARS-CoV-2 protease second Structure susceptible the SARS-CoV-2 therapeutic THR26 Treatment Vaccine viral infection worldwide pandemic Wuhan, China [DOI] 10.1016/j.molstruc.2021.131920 [Article Type] Research article
Impact of cytokine storm on severity of COVID-19 disease in a private hospital in West Jakarta prior to vaccination백신 접종 전 서부 자카르타의 사립 병원에서 사이토카인 폭풍이 COVID-19 질병의 중증도에 미치는 영향Research Article Published on 2022-01-252022-09-12 Journal: PLoS ONE [Category] 진단, [키워드] Administered Admission age Antibiotics Azithromycin B-complex Clinical outcome Cold Combination combination treatment Comorbidity contrary convenience sampling coronavirus disease Coronavirus disease 2019 correlation cough COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 positive patient Critical Critically ill critically ill patients cured Cytokine storm Cytokine storms diabete diabetes died disease duration of treatment effective therapy enrolled Factor fatigue Favipiravir Fever global health Health high mortality rate hospital Hospitalized Hydroxychloroquine hypertension ICU Immunoglobulin Impact include inclusion criteria Indonesia injection intensive care intensive care unit interleukin-6 interleukin-6 receptor investigated Jakarta less levofloxacin material mineral Minerals Ministry of Health MOST Most patient Most patients oseltamivir oxygen oxygen saturation Patient patients died plasma Private receiving receptor antagonist Remdesivir reported Result retrospective cohort study severity of COVID-19 Severity of infection Shortness of breath SpO2 survival rate survived Symptom Symptoms the cytokine storm therapy Tocilizumab treat treated Treatment utilised vaccination Vitamin vitamins vitamins C was used West worldwide pandemic [DOI] 10.1371/journal.pone.0262438 PMC 바로가기 [Article Type] Research Article
Coagulation System Activation for Targeting of COVID-19: Insights into Anticoagulants, Vaccine-Loaded Nanoparticles, and Hypercoagulability in COVID-19 VaccinesReview Published on 2022-01-242022-10-28 Journal: Viruses [Category] COVID-19, [키워드] Activation acute respiratory syndrome addition Anticoagulant anticoagulant agent anticoagulant therapy Anticoagulants Blood coagulation Coagulation system Coagulopathy Complication complications coronavirus COVID-19 COVID-19 vaccine COVID-19 vaccines cytokine Cytokine storm D-dimer Degradation drugs elevated help hypercoagulability immune Infection Inflammation insight life-threatening lower mortality mitigate Mortality Nanoparticles natural anticoagulants organ damage outbreak overlap Patient poor prognosis Prevalence Research responsible SARS-CoV-2 severe COVID-19 Side effect symptoms of COVID-19 syndrome System targeting thrombosis Treatment with COVID-19 worldwide pandemic [DOI] 10.3390/v14020228 PMC 바로가기 [Article Type] Review
Outcome of SARS-CoV-2-Infected Polish Patients with Chronic Lymphocytic LeukemiaArticle Published on 2022-01-222022-10-31 Journal: Cancers [Category] COVID-19, [키워드] acute respiratory syndrome Administered advanced age Analysis Anti-CD20 antibody chronic chronic lymphocytic leukemia clinical experience CLL CLL patient Concentration coronavirus Course COVID-19 COVID-19 patient death died elevated lactate dehydrogenase Factor Hematological malignancy hemoglobin Hospitalization increased risk Infection inhibitor leukemia naïve outcome Patient performance status performed Platelet Prognosis required Retrospective study risk of death SARS-CoV-2 SARS-COV-2 infection significantly shorter simple survival the SARS-CoV-2 therapy treated Treatment tyrosine venetoclax with COVID-19 worldwide pandemic [DOI] 10.3390/cancers14030558 PMC 바로가기 [Article Type] Article