Immunodominant linear B cell epitopes in the spike and membrane proteins of SARS-CoV-2 identified by immunoinformatics prediction and immunoassay면역정보학 예측 및 면역분석으로 확인된 SARS-CoV-2의 스파이크 및 막 단백질의 면역우성 선형 B 세포 에피토프Article Published on 2021-10-142022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] Amino acid amino acid change amino acid changes Analysis B cell B cell epitope B cell epitopes C-terminus Computational biology and bioinformatics convalescent sera COVID-19 infected patients death decrease Efficacy ELISA ENhance epitope epitope mapping Epitopes greater highlighting immunoassay immunodominant immunodominant epitopes immunoinformatics immunology IMPROVE increase in infect infected patients linear linear B M protein membrane membrane protein Microbiology NTD number of deaths predicted Protein provide RBD Region resulting S1/S2 cleavage site S2 domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike receptor-binding domain SARS-CoV-2 vaccine sera spike receptor-binding domain subunit Subunit vaccine the SARS-CoV-2 Vaccine Vaccine design vaccine efficacy variants variants of concern Viral [DOI] 10.1038/s41598-021-99642-w PMC 바로가기 [Article Type] Article
BCEPS: A Web Server to Predict Linear B Cell Epitopes with Enhanced Immunogenicity and Cross-ReactivityBCEPS: 향상된 면역원성과 교차 반응성으로 선형 B 세포 에피토프를 예측하는 웹 서버Article Published on 2021-10-142022-09-11 Journal: Cells [Category] MERS, SARS, 치료기술, 치료제, [키워드] Accessibility Accuracy antibody antigen-specific antibody antigens B cell epitope B cell epitopes B cells best conformational cross-reactive antibodies cross-reactive antibody dataset detect ectodomain ectodomains enhanced epitope Epitopes flexibility hydrophilicity identify IEDB Immune Epitope Database immunogenic immunogenicity independent linear linear B machine learning machine learning model membrane protein Membrane proteins MHC II molecules N-glycosylation site Neutralizing antibodies peptide-based vaccines predicted prediction Protein protein structures reached retrieved SARS-CoV-2 SARS-CoV-2 spike protein server specific antibodies spike Spike protein structures Support support vector machine the SARS-CoV-2 Web web server [DOI] 10.3390/cells10102744 PMC 바로가기 [Article Type] Article
In Silico and In Vivo Evaluation of SARS-CoV-2 Predicted Epitopes-Based Candidate VaccineSARS-CoV-2 예측 에피토프 기반 후보 백신의 In Silico 및 In Vivo 평가Article Published on 2021-10-132022-09-10 Journal: Molecules [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome additive effect antibody antigenic B and T-cell B cell epitope B cell epitopes binding epitope candidate causative agent caused Combination combinations conserved coronavirus coronavirus 2 coronavirus disease COVID-19 infections demonstrated epitope Epitopes female groups health authorities high mortality rate Human identify immunize immunized mice immunoinformatics in silico MHC-I MHC-II mice pandemic peptide peptides prediction Protein provide public health authorities raised reactive Receptor binding domain respiratory SARS-CoV-2 SARS-CoV-2 sequence selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T-cell T-cells therapeutic intervention therapy vaccination Vaccine vaccine candidate were used [DOI] 10.3390/molecules26206182 PMC 바로가기 [Article Type] Article
Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans건강한 성인에서 SARS-CoV-2에 대한 BBIBP-CorV(Sinopharm) 및 BNT162b2(Pfizer-BioNTech) 백신에 의해 유도된 항체 및 T 세포 반응의 비교Original Article Published on 2021-10-112022-09-11 Journal: GeroScience [Category] MERS, SARS, 치료법, [키워드] adaptive Adaptive immunity Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies Anti-spike antibody BBIBP-CorV BNT162b2 cell-mediated immune response Cell-mediated immune responses Convalescent patients cumulative domain effective elicit elicited epitope Epitopes evaluate healthy healthy individuals Human humoral IFNγ ELISpot assay IFNγ-producing T cells IFNγ IgA antibodies IgA antibody IgG immune response immune responses Immunity immunologically in healthy individuals inactivated injected investigated Live virus membrane mRNA mRNA vaccine mRNA-based much lower nucleocapsid participant pattern Pfizer-BioNTech Protein Proteins Quantitative RBD S protein epitopes SARS-CoV-2 SARS-CoV-2 virus Sinopharm supplementary material T cell T cell response target the S protein These data vaccination Vaccine virus Volunteer [DOI] 10.1007/s11357-021-00471-6 PMC 바로가기 [Article Type] Original Article
Shortening Epitopes to Survive: The Case of SARS-CoV-2 Lambda VariantArticle Published on 2021-10-102022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] affecting Analysis Combination Effect epitope epitope loop shortening host immunity immunoevasion immunogenic in silico interaction energy interest investigated Lambda Lambda variant Mutation N-glycosylation site parameter Protein Region SARS-CoV-2 shortening South spread to stability the Spike thermodynamic variant viral variant [DOI] 10.3390/biom11101494 PMC 바로가기 [Article Type] Article
An Antigenic Space Framework for Understanding Antibody Escape of SARS-CoV-2 VariantsArticle Published on 2021-10-062022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] anti-SARS-CoV-2 antibody antibody Antibody Response antigenic antigenic drift antigenic site binding domain build contribute epitope escape Evolution framework heterogeneous host immunity Human identify Immune escape Immunity Mutation N-terminal domain natural infection Neutralizing antibodies Neutralizing antibody response nine NTD overlap paratope polyclonal predict RBD Region residue risk SARS-CoV-2 Space Spike protein the RBD understanding vaccination Vaccine variant variants of concern virus VoC VOCs [DOI] 10.3390/v13102009 PMC 바로가기 [Article Type] Article
Immunogenic T cell epitopes of SARS-CoV-2 are recognized by circulating memory and naïve CD8 T cells of unexposed individualsResearch Paper Published on 2021-10-062022-11-01 Journal: EBioMedicine [Category] COVID-19, MERS, SARS, [키워드] absence Activation allele analysed binding CD4 CD8 CD8 memory T cells CD8 T cell Cell circulating clone Contact convalescent coronavirus 2 Coronaviruses COVID COVID-19 cross-reactive database Donor donors epitope Evidence finding flow cytometry healthy HLA molecule HLA-A*02:01 immunogenic Immunotherapy individual individuals induce limitation memory memory T cell MHC I monomer naïve non-infected peptide pre-existing cross-reactivity proportion proteome provided reactive reactivity recent receptor respiratory SARS-CoV-2 SARS-CoV-2 antigen seasonal coronaviruses stimulate subject T cell T cell epitope T cell epitopes TCR tested Vaccine virus-specific T cell was measured [DOI] 10.1016/j.ebiom.2021.103610 PMC 바로가기 [Article Type] Research Paper
Potential Antigenic Cross-reactivity Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Dengue Viruses중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2)와 뎅기열 바이러스 간의 잠재적 항원 교차 반응성Article Published on 2021-10-052022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analyzed antibodies antibody Clinical data consequence Control control group coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cross-reactivity Dengue Dengue fever dengue virus diagnosed domain ELISA ELISA testing envelope protein enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay epitope Epitopes False-positive healthy individual identify IgA IgG IgG antibodies IgM Immunoglobulin Immunoglobulin G immunoglobulin M Implications in-silico include individual Infection Laboratory features lead Patient Patient care performed positive Potential Protein public health Rapid test respiratory S protein SARS-CoV-2 SARS-CoV-2 epitope SARS-CoV-2 epitopes serology serum sample serum samples severe acute respiratory syndrome Coronavirus similarities similarity Spike protein Structural analysis subject Support tested the S protein the spike protein West West Nile [DOI] 10.1093/cid/ciaa1207 PMC 바로가기 [Article Type] Article
A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants수용체 결합 도메인과 N-말단 도메인 중화 항체의 조합은 SARS-CoV-2 스파이크 중화-도피 돌연변이의 생성을 제한합니다Research Article Published on 2021-10-052022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] analyzed antibody approved binding characterized Combination COVID-19 COVID-19 convalescent donor COVID-19 convalescent donors defined Effectiveness Efficacy Emergency use ENhance epitope Epitopes escape mutants FDA Generation hACE2 in vitro include inhibit less memory B-cell MOST mutant Mutation N-terminal domain NAb NAbs neutralization Neutralization assay neutralization assays neutralization potency NTD Protein RBD RBD-targeting nAbs Receptor-binding domain reduce reduced Region residue S protein SARS-CoV-2 SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 S protein SARS2 sera spike spike mutations stomatitis susceptible the RBD the receptor-binding domain therapy utility Vaccine variants variants of concern vesicular stomatitis vesicular stomatitis virus Viral viral infection VoC yeast [DOI] 10.1128/mBio.02473-21 PMC 바로가기 [Article Type] Research Article
N-terminal domain mutations of the spike protein are structurally implicated in epitope recognition in emerging SARS-CoV-2 strainsResearch Article Published on 2021-10-042022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract Acquired acute respiratory syndrome Affect affecting Ala Amino acid caused convalescent plasma coronavirus Coronaviruses Critical Deletion Epidemiological study epitope global pandemic identify Immune escape immunoreactivity implicated Interaction less Mutation N-terminal domain N-terminal domain mutations neutralizing antibody NTD RBD Receptor binding domain SARS-CoV SARS-CoV-2 SARS-CoV-2 strain Spike protein strain Strains the RBD the SARS-CoV-2 the SARS-CoV-2 genome the spike protein Transmissibility variety Virus evolution virus infectivity Wuhan strain [DOI] 10.1016/j.csbj.2021.10.004 PMC 바로가기 [Article Type] Research Article