Neutralizing activity – Page 40 – Communicable Diseases Research

A high-affinity RBD-targeting nanobody improves fusion partner’s potency against SARS-CoV-2

고친화성 RBD 표적 나노바디는 SARS-CoV-2에 대한 융합 파트너의 효능을 향상시킵니다

Research Article

Published on 2021-03-032022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, COVID-19, SARS,

Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2

SARS-CoV-2에 대한 회복기 혈장의 중화 활성에서 IgM의 주요 역할

Article

Published on 2021-03-022022-09-12
Journal: Cell Reports [Category] MERS, SARS, 진단,

Evolution of antibody immunity to SARS-CoV-2

SARS-CoV-2에 대한 항체 면역의 진화

Article

Published on 2021-03-012022-09-11
Journal: Nature [Category] Fulltext, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected Analysis animal model animal models antibody antibody immunity antibody level antibody levels Antigen assays asymptomatic individual Asymptomatic individuals B cells biopsy bowel Cell Cohort coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 death decrease Evolution examined Express greater humoral Humoral response IgA IgG antibodies IgM and IgG immunofluorescence immunoreactivity individual individuals Infection infection with SARS-CoV-2 intestinal intestinal biopsies knowledge less levels of antibody memory memory B memory B cell memory B cells memory response Neutralizing activity nucleic acids PCR persistence plasma PROTECT pseudotype virus RBD RBD mutation RBD mutations RBD-specific memory B cells Receptor-binding domain Reinfection required respiratory responsible SARS-CoV-2 SARS-CoV-2 nucleic acid severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly Spike protein the antibody the receptor-binding domain the spike protein titre titres
[DOI] 10.1038/s41586-021-03207-w PMC 바로가기 [Article Type] Article

Antibody Response against SARS-CoV-2 and Seasonal Coronaviruses in Nonhospitalized COVID-19 Patients

입원하지 않은 COVID-19 환자의 SARS-CoV-2 및 계절성 코로나바이러스에 대한 항체 반응

Research Article

Published on 2021-02-242022-09-10
Journal: mSphere [Category] MERS, 진단, 치료기술, 치료법, 치료제,

[키워드] 229E addition addressed ADE antibody Antibody Response antibody response against Antibody responses Antibody-dependent enhancement antibody-dependent enhancement (ADE) Asymptomatic breadth conducted contribute coronavirus coronavirus 229E correlated Course COVID-19 cross-protection detect develop diagnostic diagnostic test difficulty Dilution disease experiments highlight Hospitalization human cell human cells Immunity individual infected individuals Infection involved majority marker Mild neutralization Neutralizing activity Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses nucleocapsid Patient phenomenon positive predictor quantified question receptor binding site response S protein SARS-CoV-2 SARS-CoV-2 neutralization seasonal seasonal coronaviruses sera serological Serological assay serological survey Serum Neutralization Spike protein surrogate markers symptomatic targets the S protein the spike protein to define Vaccine development Virus neutralization western blot
[DOI] 10.1128/mSphere.01145-20 PMC 바로가기 [Article Type] Research Article

Rapid Development of SARS-CoV-2 Spike Protein Receptor-Binding Domain Self-Assembled Nanoparticle Vaccine Candidates

SARS-CoV-2 스파이크 단백질 수용체 결합 도메인 자가 조립 나노입자 백신 후보의 신속한 개발

Article

Published on 2021-02-232022-09-12
Journal: ACS Nano [Category] MERS, 진단,

[키워드] ACE2 adjuvant adopted angiotensin-converting enzyme 2 Antisera binding blocked candidate caused coronavirus disease covalent conjugation COVID-19 development domain effective exhibited flexible greater Health highlight immunization immunized in vitro membrane fusion mice monomeric RBD MOST nanoparticle Nanoparticles Neutralizing activity pandemic platform produced pseudovirus Rapid RBD receptor Receptor binding Receptor binding domain resulting SARS-CoV-2 SARS-CoV-2 coronavirus sera sigma spike SpyTag-SpyCatcher System the RBD the SARS-CoV-2 the spike protein the vaccine Vaccine vaccine candidate vaccine candidates Vaccine development virus
[DOI] 10.1021/acsnano.0c08379 PMC 바로가기 [Article Type] Article

Seroconversion and Abundance of IgG Antibodies against S1-RBD of SARS-CoV-2 and Neutralizing Activity in the Chilean Population

칠레 인구에서 SARS-CoV-2의 S1-RBD 및 중화 활성에 대한 IgG 항체의 혈청전환 및 풍부

Clinical Trial

Published on 2021-02-192022-09-10
Journal: Journal of Immunology Research [Category] MERS, 임상, 진단, 치료기술,

Isolation of SARS-CoV-2 strains carrying a nucleotide mutation, leading to a stop codon in the ORF 6 protein

ORF 6 단백질에서 정지 코돈으로 이어지는 뉴클레오티드 돌연변이를 지닌 SARS-CoV-2 균주의 분리

Case Reports

Published on 2021-02-182022-09-10
Journal: Emerging Microbes & Infections [Category] SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Amino acid amino acids antibodies Antiviral antiviral activity C terminus Complete coronavirus Course COVID-19 COVID-19 pathogenesis COVID-19 patients Deletion detrimental dual GenBank database genome sequence GISAID homology homology analysis hospital host response IFN in vitro interferon isolate Italian Lineage Mutation Neutralizing activity not affect nucleotide ORF ORF6 other coronaviruses physician Protein respiratory responsible SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 strain sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 stop codon Swab the disease the patient the SARS-CoV-2 unique Viral viral pathogenesis viral replication
[DOI] 10.1080/22221751.2021.1884003 PMC 바로가기 [Article Type] Case Reports

Flow cytometry multiplexed method for the detection of neutralizing human antibodies to the native SARS‐CoV‐2 spike protein

천연 SARS-CoV-2 스파이크 단백질에 대한 중화 인간 항체 검출을 위한 유동 세포 계측법 다중화 방법

Article

Published on 2021-02-172022-09-11
Journal: EMBO Molecular Medicine [Category] MERS, SARS, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus antibody blood donor Blood donors classification coding sequence COVID‐19 cytometer Cytometry detect EGFR example expresse expressed Flow flow cytometry fluorescence intensities fluorescence intensity human population immune Immunoglobulin immunoglobulins immunology individual Infection method Methods & Resources Microbiology, Virology & Host Pathogen Interaction Neutralizing Neutralizing activity outbreak pandemic PCR Protective Protein Quantitative repeated respiratory S protein SARS‐CoV‐2 SARS‐CoV‐2 separated sequence sera serological test Serological tests seropositive individual seropositive individuals Seropositivity severe acute respiratory syndrome Coronavirus Spike protein T cell T‐cell
[DOI] 10.15252/emmm.202013549 PMC 바로가기 [Article Type] Article

Neutralizing Human Antibodies against Severe Acute Respiratory Syndrome Coronavirus 2 Isolated from a Human Synthetic Fab Phage Display Library

인간 합성 Fab 파지 디스플레이 라이브러리에서 분리된 중증 급성 호흡기 증후군 코로나바이러스 2에 대한 인간 항체 중화

Article

Published on 2021-02-152022-09-12
Journal: International Journal of Molecular Sciences [Category] MERS, 진단,

[키워드] absence ACE2 activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinities angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antibody therapeutics apparent affinity avidity caused Cell coronavirus coronavirus 2 COVID-19 cross-reactivity D12 develop diagnostics display domain drug target Effect Fab Fabs FIVE Human human monoclonal antibodies Human monoclonal antibody IgGs Immunoglobulin In vitro assay Interaction Isolated library mAb mAbs MERS MERS-CoV moderate monoclonal antibody neutralize neutralizing activities Neutralizing activity outbreak pandemic phage phage display Prophylactic RBD reagent receptor protein Receptor-binding domain reported Research respiratory resulting SARS-CoV spike protein SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus significantly Spike protein Spread synthetic the RBD the SARS-CoV-2 therapeutic drug thermal stability treat unique Vaccine Viral viral entry virus Wuhan Wuhan, China yielding
[DOI] 10.3390/ijms22041913 PMC 바로가기 [Article Type] Article

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape

구조 유도 다가 나노바디는 SARS-CoV-2 감염을 차단하고 돌연변이 탈출을 억제합니다

Research Article

Published on 2021-02-122022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, MERS, 변종, 진단, 치료기술,

[키워드] absence activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Administered alpaca antibodies antibody Attention battle binding binding mode binding modes Bivalent catalyzed caused Cell cellular membrane cellular membranes change Combination combinations complex conformation conformational change Consequences coronavirus COVID-19 cryo-EM Crystallography determined by domain effective epitope Epitopes escape mutant escape mutants Evolution experiment experiments expression fusion Health care health care systems High-risk patients immune system immunization immunized inactivated inactivated virion inactive independent induce Infection information inhalation inhibit inhibited Interaction interactions lead llama mechanism Microscopy monoclonal antibodies multivalent mutants nanobodies nanobody neutralization neutralize neutralized Neutralizing Neutralizing activity observation offer pandemic passive immunization Perspective postfusion Premature Prevent prevented Protein RBD RBDs receptor receptor ACE2 Receptor binding Receptor binding domain respiratory resulting reveal Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 spike trimer Science severe acute respiratory syndrome Coronavirus Simultaneous Society Spike protein spike trimers Spread stomatitis strength Structure structures suppress suppressed target membrane target membranes the RBD the SARS-CoV-2 the spike protein to define Trigger triggered triggering triggers trimeric spike trivalent Vaccines variable vesicular stomatitis vesicular stomatitis virus Viral viral escape viral infection viral infections viral spike protein virion virions virus X-ray crystallography
[DOI] 10.1126/science.abe6230 PMC 바로가기 [Article Type] Research Article