Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine유전자 발현 프로파일링을 통해 B군 수막구균 백신에 대한 유아 면역학적 및 발열 반응에 대한 통찰력을 보여줍니다.Article Published on 2020-11-192024-07-28 Journal: Molecular Systems Biology [Category] 백일해, 파상풍, [키워드] immunology Microbiology, Virology & Host Pathogen Interaction paediatrics proteomics Systems biology transcriptomics Vaccines [DOI] 10.15252/msb.20209888 PMC 바로가기 [Article Type] Article
Multiplexed quantitative proteomics provides mechanistic cues for malaria severity and complexity다중 정량 단백질체 분석은 말라리아의 중증도와 복잡성에 대한 기계적 단서를 제공합니다.Article Published on 2020-11-172024-08-11 Journal: Communications Biology [Category] 말라리아, [키워드] mass spectrometry Parasitic infection proteomics [DOI] 10.1038/s42003-020-01384-4 PMC 바로가기 [Article Type] Article
Immune suppression in the early stage of COVID-19 diseaseArticle Published on 2020-11-172022-10-04 Journal: Nature Communications [Category] SARS, 바이오마커, 임상, 치료기술, 치료법, [키워드] activated affected change clinical feature COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathology COVID-19 patient driver early stage healthy donor identify immune response Immunosuppression immunosuppressive impairment in healthy individual Infectious disease Infectious diseases mechanism moderate molecular Non-COVID-19 occur outbreak Pathogenesis Patient patients patients with COVID-19 Pneumonia pneumonia case protein expression Proteomic analysis proteomics Quantitative resource Urine viral infection worldwide pandemic [DOI] 10.1038/s41467-020-19706-9 PMC 바로가기 [Article Type] Article
Transcriptional and proteomic insights into the host response in fatal COVID-19 cases치명적인 COVID-19 사례의 숙주 반응에 대한 전사 및 단백질 분석Case Reports Published on 2020-11-102022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] active viral infection Analysis cathepsin caused changes in clinical Colon colonic coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19-related death death died disease pathogenesis disease severity drug target examination expressed fatal COVID-19 feature fibrosis finding First wave fulminant infection global pandemic greater Host host response host responses human lung tissue immune immunological impacted Infection Inflammatory Inflammatory response lung lung parenchyma lung tissue majority molecular NETosis neutrophil neutrophil activation nine offer pandemic Pathogenesis pathophysiology pathway Pathways Patient patients with COVID-19 potential therapeutic target potential therapeutic targets primary site protease Proteins proteome proteomic proteomics pulmonary fibrosis Respiratory failure response S100A8 SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease severe SARS severe SARS-CoV-2 Significance suggested the patient the SARS-CoV-2 transcriptional Transcriptome up-regulated Viral viral burden viral infection Wuhan Wuhan, China [DOI] 10.1073/pnas.2018030117 PMC 바로가기 [Article Type] Case Reports
Mass-Spectrometric Detection of SARS-CoV-2 Virus in Scrapings of the Epithelium of the Nasopharynx of Infected Patients via Nucleocapsid N ProteinArticle Published on 2020-11-062023-07-12 Journal: Journal of Proteome Research [Category] SARS, [키워드] COVID-19 mass-spectrometry proteomics SARS-CoV-2 TIMS-TOF PRO [DOI] 10.1021/acs.jproteome.0c00412 PMC 바로가기
Proteomics and Informatics for Understanding Phases and Identifying Biomarkers in COVID-19 DiseaseReview Published on 2020-11-062023-07-12 Journal: Journal of Proteome Research [Category] SARS, [키워드] artificial intelligence assay Biomarker COVID-19 Diagnosis marker Prognosis proteomics SARS-CoV-2 [DOI] 10.1021/acs.jproteome.0c00326 PMC 바로가기 [Article Type] Review
Evidence of Structural Protein Damage and Membrane Lipid Remodeling in Red Blood Cells from COVID-19 PatientsObservational Study Published on 2020-11-062023-07-06 Journal: Journal of Proteome Research [Category] SARS, [키워드] AE1 band 3 erythrocyte Lipidomics metabolomics proteomics SARS-CoV-2 [DOI] 10.1021/acs.jproteome.0c00606 PMC 바로가기 [Article Type] Observational Study
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19COVID-19에 대한 질병 징후 및 약물 용도 변경에 대한 조사 및 인구 기반 검증에 대한 네트워크 의학 접근 방식Observational Study Published on 2020-11-062022-08-13 Journal: PLoS Biology [Category] Medicine and Health Sciences, 신약개발, 유전자 메커니즘, 임상, [키워드] 95% CI ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ADRB2 African American African Americans age Analysis angiotensin Angiotensin II angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors approach approved Asthma asthma patient asthma patients blocker candidate caused Chain Reaction co-expression Comorbidity Consequences coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Crohn disease database disease disease manifestation elevated Enterocyte host protein identify ileal increase individual Inflammatory Inflammatory bowel disease IRAK3 Laboratory Laboratory test likelihood Manifestations mechanism Medical conditions melatonin metabolomics methodology molecular morbidity morbidity and mortality network observation observational study Odds ratio pandemic Pathogenesis Patient platform positive positive test result potential treatments Propensity score protein interactions protein–protein interactions proteome proteomics receptor Receptor Blockers reduced respiratory risk SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 virus severe acute respiratory syndrome Coronavirus Sex significantly single-cell Single-cell RNA sequencing smoking test result therapy tissue tissues TMPRSS2 Transcriptome transcriptomics Treatment treatment of COVID-19 widespread with COVID-19 [DOI] 10.1371/journal.pbio.3000970 PMC 바로가기 [Article Type] Observational Study
The use of proteomics for the identification of promising vaccine and diagnostic biomarkers in Plasmodium falciparumarticle Published on 2020-10-312024-09-01 Journal: Parasitology [Category] 말라리아, [키워드] Diagnostic marker malaria Plasmodium falciparum proteomics vaccine target [Article Type] article
Aprotinin Inhibits SARS-CoV-2 Replication아프로티닌은 SARS-CoV-2 복제를 억제합니다Article Published on 2020-10-302022-09-11 Journal: Cells [Category] MERS, SARS, 진단, 치료제, [키워드] 2019-nCoV acute respiratory syndrome air–liquid interface Alpha Analysis Anti-SARS-CoV-2 Activity Antiviral approved Aprotinin Caco2 Calu Calu-3 Cell cell type cell types cellular proteases cleavage Concentration concentrations coronavirus coronavirus disease COVID-19 COVID-19 progression cultures disease downregulated downregulation Drug discovery epithelial epithelial cell host cell host cell protease host cell proteases indicated inhibited inhibitor isolates Local local control pandemic Prevent prevention of COVID-19 progression Protease inhibitor protease inhibitors Protein proteomics respiratory SARS-CoV-2 SARS-CoV-2 replication SERPINA1 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe acute respiratory syndrome virus systemic disease therapeutic virus virus entry virus replication [DOI] 10.3390/cells9112377 PMC 바로가기 [Article Type] Article