Neutralizing antibody activity in convalescent sera from infection in humans with SARS-CoV-2 and variants of concernSARS-CoV-2 및 우려되는 변이체 감염으로 인한 회복기 혈청의 중화 항체 활성Article Published on 2021-10-152022-09-10 Journal: Nature Microbiology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] (alpha (Beta) Alpha antibody B.1.1.7 B.1.617.2 B1.351 Beta convalescent sera COVID-19 vaccine design cross-neutralization cross-neutralizing cross-reactivity Delta Human humans IMPROVE individual infecting Infection less Lineage maturation neutralization neutralization activity neutralization potency neutralize Neutralizing antibodies neutralizing antibody onset of symptoms optimization over parental PROTECT Proteins raised reduced reduction in SARS-CoV-2 SARS-CoV-2 variants sera spike mutations Spike proteins Tolerance unique vaccination Vaccine vaccine candidates variant variant spike variants variants of concern viral infection virus VoC VOCs Wave while [DOI] 10.1038/s41564-021-00974-0 PMC 바로가기 [Article Type] Article
Detection of Serum Cross-Reactive Antibodies and Memory Response to SARS-CoV-2 in Prepandemic and Post–COVID-19 Convalescent Samples전염병 전 및 코로나19 이후 회복기 샘플에서 SARS-CoV-2에 대한 혈청 교차 반응성 항체 및 기억 반응 검출Major Articles and Brief Reports Published on 2021-10-152022-09-10 Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] 19 2 Activation acute respiratory syndrome acute respiratory syndrome coronavirus Adults Anti-S1 anti–SARS-CoV-2 IgG antibody antibodies antibody Antibody titer Antibody titers antigens children collected common human coronavirus (HCoV)-HKU1 convalescent COVID-19 patient convalescent COVID-19 patients coronavirus coronavirus disease Coronavirus disease 2019 correlated CoV COVID COVID-19 cross cross-reactive cross-reactive antibody demonstrated detectable detection domain effective Endemic endemic human coronavirus endemic human coronaviruses enzyme enzyme-linked immunosorbent assays HCoV HCoVs HKU1 IgG antibodies Immunity Immunological memory increase Infection investigated lead less memory response Neutralization assay Neutralizing activity NL63 notable novel coronaviruses nucleocapsid protein OC43 Promoting proportion reactive immunity respiratory response Result Sample SARS SARS-CoV-2 SARS-CoV-2 pseudotyped virus SARS-CoV-2 S1 sera serum antibody serum sample serum samples severe disease susceptible β-coronavirus β-Coronaviruses [DOI] 10.1093/infdis/jiab333 PMC 바로가기 [Article Type] Major Articles and Brief Reports
Immunodominant linear B cell epitopes in the spike and membrane proteins of SARS-CoV-2 identified by immunoinformatics prediction and immunoassay면역정보학 예측 및 면역분석으로 확인된 SARS-CoV-2의 스파이크 및 막 단백질의 면역우성 선형 B 세포 에피토프Article Published on 2021-10-142022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] Amino acid amino acid change amino acid changes Analysis B cell B cell epitope B cell epitopes C-terminus Computational biology and bioinformatics convalescent sera COVID-19 infected patients death decrease Efficacy ELISA ENhance epitope epitope mapping Epitopes greater highlighting immunoassay immunodominant immunodominant epitopes immunoinformatics immunology IMPROVE increase in infect infected patients linear linear B M protein membrane membrane protein Microbiology NTD number of deaths predicted Protein provide RBD Region resulting S1/S2 cleavage site S2 domain SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 spike receptor-binding domain SARS-CoV-2 vaccine sera spike receptor-binding domain subunit Subunit vaccine the SARS-CoV-2 Vaccine Vaccine design vaccine efficacy variants variants of concern Viral [DOI] 10.1038/s41598-021-99642-w PMC 바로가기 [Article Type] Article
Limited Neutralization of Authentic Severe Acute Respiratory Syndrome Coronavirus 2 Variants Carrying E484K In VitroE484K를 체외에서 운반하는 정통 중증 급성 호흡기 증후군 코로나바이러스 2 변이의 제한된 중화Article Published on 2021-10-132022-09-11 Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 변종, 진단, [키워드] (Alpha) (Beta acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha antibody B.1.1.7 B.1.351 bamlanivimab Beta Carrying Casirivimab convalescent coronavirus coronavirus 2 E484K Imdevimab investigated less Limited monoclonal monoclonal antibodies monoclonal antibody neutralize P.2 pseudoviruses respiratory SARS-CoV-2 sera severe acute respiratory syndrome Coronavirus susceptible vaccination variant variants variants of concern Zeta [DOI] 10.1093/infdis/jiab355 PMC 바로가기 [Article Type] Article
Presence of Antibodies to SARS-CoV-2 in Domestic Cats in Istanbul, Turkey, Before and After COVID-19 PandemicVeterinary Science Published on 2021-10-122022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] acute respiratory syndrome alanine aminotransferase analyzed antibody cat Contact coronavirus coronavirus disease Coronavirus-2 COVID-19 COVID-19 pandemic demonstrated ELISA exhibited hematocrit hemoglobin İstanbul limit liver enzyme lymphocyte monocyte neutrophil Platelet positive Presence presence of antibody RBD recent renal risk SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 infections SARS-CoV-2-specific antibody sera seropositive Serum Neutralization skin lesions spike tested Turkey was performed White blood cells with COVID-19 [DOI] 10.3389/fvets.2021.707368 PMC 바로가기 [Article Type] Veterinary Science
Neutralization of Delta variant with sera of Covishield™ vaccinees and COVID-19-recovered vaccinated individualsCovishield™ 백신 접종자 및 COVID-19 회복 백신 접종 개인의 혈청으로 Delta 변이체 중화Article Published on 2021-10-112022-09-11 Journal: Journal of Travel Medicine [Category] MERS, SARS, 변종, 진단, [키워드] Abstract Adenoviral-vector vaccines AstraZeneca AZD1222 ChAdOx-1 delta variant sera vaccinated individual Vaccine vaccine effectiveness vaccinee variants variants of concern [DOI] 10.1093/jtm/taab119 PMC 바로가기 [Article Type] Article
Neutralization of Beta and Delta variant with sera of COVID-19 recovered cases and vaccinees of inactivated COVID-19 vaccine BBV152/CovaxinCOVID-19 회복 사례 및 비활성화된 COVID-19 백신 BBV152/Covaxin의 백신 접종자 혈청으로 베타 및 델타 변이체 중화Article Published on 2021-10-112022-09-11 Journal: Journal of Travel Medicine [Category] MERS, SARS, 변종, 진단, [키워드] Beta COVID-19 COVID-19 vaccine Delta delta variant Efficacy global public health inactivated neutralization SARS-CoV-2 SARS-CoV-2 variant sera Vaccine vaccine efficacy vaccinee Vaccines variant variants [DOI] 10.1093/jtm/taab104 PMC 바로가기 [Article Type] Article
Neutralization of VUI B.1.1.28 P2 variant with sera of COVID-19 recovered cases and recipients of Covaxin an inactivated COVID-19 vaccineCOVID-19 회복 사례 및 비활성화된 COVID-19 백신인 Covaxin의 수혜자의 혈청을 사용한 VUI B.1.1.28 P2 변이체의 중화Article Published on 2021-10-112022-09-11 Journal: Journal of Travel Medicine [Category] MERS, SARS, 변종, 진단, [키워드] B.1.1.28 B.1.1.28.2 Covaxin COVID-19 COVID-19 vaccine inactivated individual natural infection neutralization Neutralizing titer recipient reductions in SARS-CoV-2 sera shown Vaccine variant [DOI] 10.1093/jtm/taab077 PMC 바로가기 [Article Type] Article
Serum IgG anti-SARS-CoV-2 Binding Antibody Level Is Strongly Associated With IgA and Functional Antibody Levels in Adults Infected With SARS-CoV-2혈청 IgG 항-SARS-CoV-2 결합 항체 수준은 SARS-CoV-2에 감염된 성인의 IgA 및 기능적 항체 수준과 밀접한 관련이 있습니다Immunology Published on 2021-10-082022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] ACE-2 receptor acute respiratory syndrome Adults age anti-S anti-S antibody anti-S ELISA anti-SARS-CoV-2 antibody binding antibody concentrations coronavirus coronavirus disease correlation COVID-19 cumulative cutoff value demographic groups demonstrated diagnostic disease severity ELISA ELISAs Endemic enzyme Epidemiology evaluate evaluated female full length full-length functional functional antibody human serum IgA IgG immunosorbent Level male Negative predictive value neutralizing antibody NPV pandemic positive Positive predictive value PPV Protein Quantitative reported Result robust S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibody SARS-CoV-2 PCR SARS-CoV-2 seroprevalence sensitivity sera Serological assay serology serum dilution Significant significantly higher specificity Spread Surveillance Symptom Test statistics to define vaccine candidate were measured Wuhan, China yielding [DOI] 10.3389/fimmu.2021.693462 PMC 바로가기 [Article Type] Immunology
ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7ChAdOx1 nCoV-19(AZD1222)는 SARS-CoV-2 B.1.351 및 B.1.1.7로부터 시리아 햄스터를 보호합니다.Article Published on 2021-10-072022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] animals Antibody titer AZD1222 B.1.1.7 B.1.1.7 variants B.1.351 caused ChAdOx1 ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 vaccine clinical disease disease Effectiveness Efficacy hamster hamsters infection with SARS-CoV-2 Infectious virus investigated lesions Live attenuated vaccines lose weight lung Lungs Neutralizing antibody titer observé Pathogens Pneumonia PROTECT Pulmonary infection Pulmonary pathology raise reduction Replication RNA SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 variant SARS-CoV-2 variants sera sgRNA single dose These data Vaccine Vaccines Viral virus VOCs weight [DOI] 10.1038/s41467-021-26178-y PMC 바로가기 [Article Type] Article