Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interactionSARS-COV-2 스파이크 수용체 결합 도메인의 돌연변이 조경 및 실리코 구조 모델에서 바이러스-호스트 상호 작용에 대한 주요 분자 결정 인자를 나타냅니다.Research Published on 2022-01-072022-09-10 Journal: BMC Molecular and Cell Biology [Category] 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 binding alteration Amino acid amino acid residues amino acid substitution Analysis analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bat-CoV binding binding affinities binding affinity Binding interface causative agent changes in Clusters conserved Contact COVID-19 pandemic Deleterious mutations determinant enzyme focus Formation functional Future G496 G502 globe Host in silico in-silico independent infections Interaction interface mechanism molecular molecular rearrangement mutants mutate Mutation mutations N487 Non-synonymous mutation pandemic pangolin pangolin-CoV Phylogenetic analysis Protein Randomly RBD RBD mutation RBD mutations RBD residue RBD residues RBD-ACE2 RBDs Receptor binding domain reference strain remained residue Result RNA virus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 RBD SARS-CoV-2 spike shown spike Spike protein stability suggested supplementary material sustained T500 the SARS-CoV-2 therapeutically target transmission rate variants of concern Viral viral entry virus virus infectivity Wuhan Y449 [DOI] 10.1186/s12860-021-00403-4 PMC 바로가기 [Article Type] Research
Gender differences in the intention to get vaccinated against COVID-19: a systematic review and meta-analysisReview Article Published on 2022-01-072022-10-28 Journal: Zeitschrift Fur Gesundheitswissenschaften [Category] COVID-19, [키워드] 95% CI absolute frequency conducted COVID-19 COVID-19 vaccination Descriptive analysis Gender Gender differences general population samples Health care worker health care workers Intention majority men men and women Meta-analysis Odds ratio reported Result searched significantly supplementary material systematic review vaccinated against COVID-19 vaccination intention vaccination rate Web of Science women [DOI] 10.1007/s10389-021-01677-w PMC 바로가기 [Article Type] Review Article
The relationship between telework from home and employee health: a systematic review가정과 직원 건강의 원격 작업의 관계 : 체계적인 검토Research Published on 2022-01-072022-09-10 Journal: BMC Public Health [Category] SARS, 치료기술, [키워드] Affect approach assessment association Burnout category collected conducted coronavirus coronavirus disease COVID-19 development disease E-work evaluated Evidence Exhaustion General health Globalization Health indicate knowledge leisure Leisure satisfaction life Life satisfaction methodological Newcastle-Ottawa Scale outcome outcomes Pain pandemic Participants peer-reviewed PsycINFO Quantitative reduce registration number Research Result Satellite work, remote work Satisfaction Stress supplementary material systematic review the Newcastle-Ottawa Scale virus spread Well-being widespread Working from home [DOI] 10.1186/s12889-021-12481-2 PMC 바로가기 [Article Type] Research
The broad spectrum of COVID-like patients initially negative at RT-PCR testing: a cohort studyRT-PCR 테스트에서 초기에 부정적인 코비드-유사 환자의 광범위한 스펙트럼 : 코호트 연구Research Published on 2022-01-072022-09-10 Journal: BMC Public Health [Category] SARS, 치료기술, [키워드] 95% confidence interval 95%CI clinical evaluation Clinical judgment clinically suspected cohort study collected data Computed tomography computed tomography scan Concordance COVID-19 COVID-19 patient COVID-19 symptoms Department detect differential diagnosis Emergency emergency department Evidence false False negative false-negative False-negative RT-PCR Fever help Hospital stay Hospitalization identify infection control information Isolation lack Logistic regression lung management negative patients negative RT-PCR Odds ratio Patient patients performed positive Probability proportion Result RT-PCR RT-PCR test subsequent supplementary material Symptom syndrome tested two group two groups Univariate analysis variable variables with COVID-19 [DOI] 10.1186/s12889-021-12409-w PMC 바로가기 [Article Type] Research
Impact of exposure time in awake prone positioning on clinical outcomes of patients with COVID-19-related acute respiratory failure treated with high-flow nasal oxygen: a multicenter cohort studyResearch Published on 2022-01-072022-11-01 Journal: Critical Care [Category] COVID-19, [키워드] 95% CI Acute respiratory failure adjust adjusted age Analysis analyzed ARF Awake Awake prone positioning Clinical outcome confounders controls COVID-19 Effect Endotracheal intubation evaluated HFNO High-flow nasal oxygen hospital ICU Impact in-hospital mortality intubation inverse Mortality multicenter multicenter cohort study nasal Patient patients treated primary analysis Primary outcome Probability Prone position prospective cohort study receiving reduce reduced reduction in Respiratory failure Result risk screened secondary outcome sensitivity analysis study period study population supplementary material treated Treatment variable was used [DOI] 10.1186/s13054-021-03881-2 PMC 바로가기 [Article Type] Research
COVID-19 related outcomes among individuals with neurodegenerative diseases: a cohort analysis in the UK biobankResearch Article Published on 2022-01-072022-10-27 Journal: BMC Neurology [Category] COVID-19, [키워드] 95%CI adjusted adjusted odds ratio applied association both group Care Clinical diagnosis cohort analysis cohort study community-based cohort study Comorbidities confounder COVID-19 death defined Diagnosis disease Diseases elevated higher risk hospital increased risk individual Longitudinal studies neurodegenerative Neurodegenerative diseases outbreak outcome outcomes participant positive test result Public Health England Result risk risk of COVID-19 SARS-CoV-2 SARS-CoV-2 test suggested supplementary material susceptibility UK biobank [DOI] 10.1186/s12883-021-02536-7 PMC 바로가기 [Article Type] Research Article
COVID-19 related outcomes among individuals with neurodegenerative diseases: a cohort analysis in the UK biobankResearch Article Published on 2022-01-072022-10-27 Journal: BMC Neurology [Category] Coronavirus, COVID-19, SARS, [키워드] 95%CI adjusted adjusted odds ratio applied association both group Care Clinical diagnosis cohort analysis cohort study community-based cohort study Comorbidities confounder COVID-19 death defined Diagnosis disease Diseases elevated higher risk hospital increased risk individual Longitudinal studies neurodegenerative Neurodegenerative diseases outbreak outcome outcomes participant positive test result Public Health England Result risk risk of COVID-19 SARS-CoV-2 SARS-CoV-2 test suggested supplementary material susceptibility UK biobank [DOI] 10.1186/s12883-021-02536-7 PMC 바로가기 [Article Type] Research Article
Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interactionResearch Published on 2022-01-072022-10-27 Journal: BMC Molecular and Cell Biology [Category] COVID-19, [키워드] ACE2 ACE2 binding alteration amino acid residues amino acid substitution Analysis analyzed bat-CoV binding binding affinity Binding interface changes in Clusters conserved Contact COVID-19 pandemic Deleterious mutations determinant Formation functional Future G496 G502 globe Host in silico in-silico independent infections Interaction mechanism molecular molecular rearrangement mutants mutate Mutation mutations N487 Non-synonymous mutation pandemic pangolin-CoV Phylogenetic analysis Protein Randomly RBD RBD mutation RBD residue RBD-ACE2 Receptor binding domain remained residue Result RNA virus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RBD SARS-CoV-2 spike shown spike Spike protein stability suggested supplementary material sustained T500 the SARS-CoV-2 therapeutically target transmission rate variants of concern viral entry virus virus infectivity Wuhan Y449 [DOI] 10.1186/s12860-021-00403-4 PMC 바로가기 [Article Type] Research
Shift of radiotherapy use during the first wave of the COVID-19 pandemic? An analysis of German inpatient dataOriginal Article Published on 2022-01-072022-10-28 Journal: Strahlentherapie Und Onkologie [Category] Coronavirus, COVID19(2023년), Fulltext, SARS, [키워드] Admission Admissions aligned Analysis applied Cancer conducted controlling COVID-19 COVID-19 pandemic Data collection defined Diagnosis First wave fraction Germany Hospital admission Hospitalized hospitals ICD-10 incidence informatics initiative linear lockdown measure objective pandemic Radiotherapy reduced reduction Result shift study cohort supplementary material Treatment [DOI] 10.1007/s00066-021-01883-1 PMC 바로가기 [Article Type] Original Article
Mutational landscape and in silico structure models of SARS-CoV-2 spike receptor binding domain reveal key molecular determinants for virus-host interactionResearch Published on 2022-01-072022-10-27 Journal: BMC Molecular and Cell Biology [Category] Coronavirus, COVID-19, SARS, [키워드] ACE2 ACE2 binding alteration amino acid residues amino acid substitution Analysis analyzed bat-CoV binding binding affinity Binding interface changes in Clusters conserved Contact COVID-19 pandemic Deleterious mutations determinant Formation functional Future G496 G502 globe Host in silico in-silico independent infections Interaction mechanism molecular molecular rearrangement mutants mutate Mutation mutations N487 Non-synonymous mutation pandemic pangolin-CoV Phylogenetic analysis Protein Randomly RBD RBD mutation RBD residue RBD-ACE2 Receptor binding domain remained residue Result RNA virus sarbecovirus Sarbecoviruses SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RBD SARS-CoV-2 spike shown spike Spike protein stability suggested supplementary material sustained T500 the SARS-CoV-2 therapeutically target transmission rate variants of concern viral entry virus virus infectivity Wuhan Y449 [DOI] 10.1186/s12860-021-00403-4 PMC 바로가기 [Article Type] Research