Establishment of Human Pluripotent Stem Cell‐Derived Skin Organoids Enabled Pathophysiological Model of SARS‐CoV‐2 Infection인간 다 능성 줄기 세포 유래 피부 오가 노이드의 확립 SARS -COV -2 감염의 병리 생리 학적 모델 가능Research Article Published on 2021-12-312022-09-10 Journal: Advanced Science [Category] MERS, SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 association can be used Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 death Drug screening epidermis Evidence feature finding hair follicle hair follicles Hair loss help Human identify infect investigated KRT17 lead Model molecular nerve cell nervous system Organoid pathological mechanism Patient proteome proteomics reported respiratory SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown skin skin cell skin organoids skin tissue STEM stem cell susceptibility [DOI] 10.1002/advs.202104192 PMC 바로가기 [Article Type] Research Article
Susceptibility of ABO blood group to COVID-19 infections: clinico-hematological, radiological, and complications analysis4800 Published on 2021-12-302022-10-30 Journal: Medicine [Category] COVID-19, SARS, [키워드] abnormality ABO ABO blood group Absolute lymphocyte count Admitted Patient age Analysis Asymptomatic Blood Blood Group clinical information commenced Community Complication Computed tomography conducted COVID-19 COVID-19 disease COVID-19 pandemic COVID-19 patients demographic disease disease manifestation distribution Evidence Faisal Glucose groups hematological hematological parameters Hospitalized hospitalized COVID-19 patient IgA incidence indicate indicated individual Infection infections information intensive care Jeddah King Laboratory majority one-way ANOVA test outcome parameters Patient pharyngeal Prognosis progression protocols radiological Research retrospective cohort study Saudi Arabia Shortness of breath specialist statistically statistically significant difference study participant susceptibility Symptom Symptoms the mean upper respiratory tract X-ray [DOI] 10.1097/MD.0000000000028334 PMC 바로가기 [Article Type] 4800
Paradoxical sex-specific patterns of autoantibody response to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 자가항체 반응의 역설적인 성별 특정 패턴Research Published on 2021-12-302022-09-10 Journal: Journal of Translational Medicine [Category] SARS, 진단, 치료법, [키워드] AABs absence Activation acute response age analyses antibody Antigen antigens assigned asymptomatic infection autoantibody autoantigen Autoantigen selectivity Autoimmune Autoimmune disease Autoimmune diseases autoreactivity blood draw breadth classic clinical disease Clustering Cohort collected COVID-19 COVID-19 illness demographic data effective intervention effective interventions Evidence evidence of exhibit extreme greater healthy control homology Immune-mediated inflammatory activity lead men men and women modulating molecular multivariable analyses nucleocapsid protein number of symptom participant presence or absence Prevalence reactivity reported symptom reported symptoms Result SARS-CoV-2 SARS-COV-2 infection serological severe COVID-19 illness Sex difference sex differences socio-demographic supplementary material susceptibility Symptom symptomatic infection Symptoms trajectory triggered within 6 months women [DOI] 10.1186/s12967-021-03184-8 PMC 바로가기 [Article Type] Research
The Usage of Antibiotics by COVID-19 Patients with Comorbidities: The Risk of Increased Antimicrobial ResistanceArticle Published on 2021-12-292022-10-27 Journal: Antibiotics [Category] COVID-19, [키워드] antibiotic antibiotic susceptibility Antibiotics antimicrobial antimicrobial resistance antimicrobial resistance pattern Antimicrobial stewardship AST Bacterial Bacterial infection Bacterial infections carbapenem Care Chronic kidney disease CKD clinical clinical implication clinics collected Comorbidities Comorbidity conducted COVID-19 COVID-19 patient diffusion method E. coli Health hospital ICU Patients identify Immunocompromised patients Increased inhibitory concentration intensive care unit isolates Klebsiella pneumoniae Local morbidity and mortality MOST pathogen Prevalence prevalent provide resistance surgical susceptibility the patient Treatment urinary tract infection Usage use of antibiotics widespread [DOI] 10.3390/antibiotics11010035 PMC 바로가기 [Article Type] Article
Diagnosis of tuberculosis among COVID-19 suspected cases in GhanaResearch Article Published on 2021-12-282022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Analysis analyzed caused Clinical sign collected complex Contact Contact tracing COVID-19 COVID-19 case COVID-19 outbreak COVID-19 patient determine diagnosed differential diagnose differential diagnosis disease District drug early stage Endemic female FIVE GeneXpert MTB/RIF assay highlight individual infect Infection involved male management Mycobacterium tuberculosis National national guidelines NTP Pandemics pathogen positive processed public health threat Respiratory illness Respiratory system Result SARS CoV-2 Sputum sample Surveillance susceptibility Symptoms tested Treatment Tuberculosis West [DOI] 10.1371/journal.pone.0261849 PMC 바로가기 [Article Type] Research Article
Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization studyResearch Published on 2021-12-242022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, [키워드] 95% CI adopted approach association associations causal relationship Cohort complications Comprehensive conducted Control Coronavirus disease 2019 COVID-19 COVID-19 severity COVID-19 susceptibility disease estimate Evidence healthcare highlighting horizontal pleiotropy Hospitalization Hospitalized host susceptibility increase initiative investigated IVW mendelian randomization MR-Egger regression outcomes pandemic periodontal disease Result retrieved risk risk factor sensitivity analysis Severe case severity severity of COVID-19 significantly significantly higher Single nucleotide polymorphism susceptibility weighted median weighted mode [DOI] 10.1186/s12967-021-03198-2 PMC 바로가기 [Article Type] Research
The Role of Angiotensin Converting Enzyme 1 Insertion/Deletion Genetic Polymorphism in the Risk and Severity of COVID-19 InfectionMedicine Published on 2021-12-232022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] ACE1 ACE1 ACE1 gene addition agarose gel age allele Analysis angiotensin association Blood carrier center clinical collected common allele Comorbidity Control COVID COVID-19 COVID-19 disease COVID-19 infection COVID-19 virus described determine disease disease severity DNA driving explain Factor Frequency Gender genetic differences Genetic polymorphism genetics Genotype genotyping greater Hospitalization I/D I/D polymorphism incidence increase in increased risk individual Infection Isolation management medical records outcome PCR PCR testing performed peripheral polymorphism positive predict Prognosis questionnaire recruited risk risk factor role severe symptom severity severity of COVID-19 Sex significantly higher significantly increased study population subjects susceptibility Symptom the disease university withdrawn [DOI] 10.3389/fmed.2021.798571 PMC 바로가기 [Article Type] Medicine
APOE ε4 associates with increased risk of severe COVID-19, cerebral microhaemorrhages and post-COVID mental fatigue: a Finnish biobank, autopsy and clinical studyAPOE ε4는 심각한 CovID-19, 뇌 미세 조혈 및 침전 후 정신 피로의 위험 증가와 관련이 있습니다. 핀란드 바이오 뱅크, 부검 및 임상 연구Research Published on 2021-12-232022-09-01 Journal: Acta Neuropathologica Communications [Category] 진단, [키워드] age allele Analysis animal model animal models ApoE APOE4 APOE4 carriers Apolipoprotein e association Autopsy Biobank Brain Brain microhaemorrhage cardiovascular disease carriers clinical manifestation clinical manifestations clinical study Cohort Control COVID-19 COVID-19 case COVID-19 mortality COVID-19 sequelae datasets Evidence fatigue Finn Finnish Finns Genetic genetic association Genetic studies histopathological examination in some increased risk information initial intensive care patient intensive care patients Mental mental fatigue Neuropathology non-infected pathology perivascular post-COVID fatigue Post-viral fatigue prevalent provide provided risk factor SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Sex shown subject supplementary material susceptibility [DOI] 10.1186/s40478-021-01302-7 PMC 바로가기 [Article Type] Research
Analysis of Preventive Behaviors of Rural Tourism Hosts in the Face of COVID-19 Pandemic: Application of Health Belief ModelPublic Health Published on 2021-12-232022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] “COVID-19 accounted application Behavior belief Community conducted COVID-19 COVID-19 pandemic Diseases Effect Efficacy face HBM Health Health Belief Model health perception Host hosts IMPROVE indicated Iran Kermanshah Model modify not significant Novel coronavirus Perceived benefits Prevent public health questionnaire reliability risk preventative behavior rural tourism hosts safety behavior SEM severity SmaRT spread of COVID-19 study population susceptibility Tourism Validity was used [DOI] 10.3389/fpubh.2021.793173 PMC 바로가기 [Article Type] Public Health
Genetically Predicted Higher Educational Attainment Decreases the Risk of COVID-19 Susceptibility and Severity: A Mendelian Randomization StudyPublic Health Published on 2021-12-232022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] 95% CI alcohol attainment body mass index confounding factors controls correlated COVID-19 COVID-19 susceptibility decrease disease educational attainment Effect genetic instrument Genome-wide association study GWAS Hospitalization indicated initiative inverse lower risk mendelian randomization morbidity and mortality Multivariable MR observational study outcomes performed physical activity Population predicted primary analysis provided public health R software resource Result risk Sedentary behavior severity severity of COVID-19 smoking statistical analysis susceptibility [DOI] 10.3389/fpubh.2021.731962 PMC 바로가기 [Article Type] Public Health